3-(4-Phenylpiperazin-1-yl)piperidin-4-ol | 888315-35-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-(4-Phenylpiperazin-1-yl)piperidin-4-ol
• CAS: 888315-35-3
• 化学式: C₁₅H₂₃N₃O
• 分子量: 261.367
• InChiKey: XFSZVQLUQJUHJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  38.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-Phenylpiperazin-1-yl)piperidin-4-ol 、 3-溴苄溴 在 三乙胺 、 potassium iodide 作用下， 以 乙醇 为溶剂， 反应 16.0h， 以82%的产率得到1-(3-Bromobenzyl)-3-(4-phenylpiperazin-1-yl)piperidin-4-ol
  参考文献：
  名称：

  Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands

  摘要：

  As dysfunction of cerebral cholinergic neurotransmission is one of the main features in patients with Alzheimer's disease, in vivo imaging of the vesicular acetylcholine transporter (VAChT) can be of great value for the early diagnosis of this disease. Two series of positional isomers of m-iodobenzyltrozamicol (MIBT): 3-hydroxy-4-(N-phenylpiperazinyl)piperidine and 4-hydroxy-3-(N-phenylpiperazinyl)piperidine substituted by benzyl, aryl, alkyl or vinyl groups at the nitrogen have been synthesized. These compounds have been evaluated in vitro by competition studies and five compounds (N-benzyl derivatives) showed high affinity for the VAChT (11 nM

  DOI：

  10.1016/j.bmcl.2006.02.033
• 作为产物：
  描述：

  在 溶剂黄146 、 锌 作用下， 反应 48.0h， 以97%的产率得到3-(4-Phenylpiperazin-1-yl)piperidin-4-ol
  参考文献：
  名称：

  Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands

  摘要：

  As dysfunction of cerebral cholinergic neurotransmission is one of the main features in patients with Alzheimer's disease, in vivo imaging of the vesicular acetylcholine transporter (VAChT) can be of great value for the early diagnosis of this disease. Two series of positional isomers of m-iodobenzyltrozamicol (MIBT): 3-hydroxy-4-(N-phenylpiperazinyl)piperidine and 4-hydroxy-3-(N-phenylpiperazinyl)piperidine substituted by benzyl, aryl, alkyl or vinyl groups at the nitrogen have been synthesized. These compounds have been evaluated in vitro by competition studies and five compounds (N-benzyl derivatives) showed high affinity for the VAChT (11 nM

  DOI：

  10.1016/j.bmcl.2006.02.033

文献信息

• Synthesis and in vitro evaluation of N-substituted aza-trozamicol analogs as vesicular acetylcholine transporter ligands
  作者：Thaer Assaad、Sylvie Mavel、Stanley M. Parsons、Shane Kruse、Laurent Galineau、Hassan Allouchi、Michael Kassiou、Sylvie Chalon、Denis Guilloteau、Patrick Emond

  DOI：10.1016/j.bmcl.2006.02.033

  日期：2006.5

  As dysfunction of cerebral cholinergic neurotransmission is one of the main features in patients with Alzheimer's disease, in vivo imaging of the vesicular acetylcholine transporter (VAChT) can be of great value for the early diagnosis of this disease. Two series of positional isomers of m-iodobenzyltrozamicol (MIBT): 3-hydroxy-4-(N-phenylpiperazinyl)piperidine and 4-hydroxy-3-(N-phenylpiperazinyl)piperidine substituted by benzyl, aryl, alkyl or vinyl groups at the nitrogen have been synthesized. These compounds have been evaluated in vitro by competition studies and five compounds (N-benzyl derivatives) showed high affinity for the VAChT (11 nM