tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-4-[(hydroxyamino)carbonyl]-1-piperidinecarboxalate | 287201-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-4-[(hydroxyamino)carbonyl]-1-piperidinecarboxalate
• 英文别名: alpha-Sulfone piperidine hydroxamate, 1d；tert-butyl 4-(4-but-2-ynoxyphenyl)sulfonyl-4-(hydroxycarbamoyl)piperidine-1-carboxylate
• CAS: 287201-44-9
• 化学式: C₂₁H₂₈N₂O₇S
• 分子量: 452.529
• InChiKey: DIUYYSMPEUKBTJ-UHFFFAOYSA-N

物化性质

• 密度：
  1.299±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-4-[(hydroxyamino)carbonyl]-1-piperidinecarboxalate 在 盐酸 作用下， 以 二氯甲烷 为溶剂， 生成 4-{[4-(2-Butynyloxy)phenyl]sulfonyl}-N-hydroxy-4-piperidinecarboxamide
  参考文献：
  名称：

  An efficient method to prepare α-sulfonyl hydroxamic acid derivatives

  摘要：

  alpha -Sulfonyl hydroxamic acid derivatives are biologically important molecules. An efficient protocol has bt en developed to mal;e these molecules via a direct sulfonylation of enolates. Several piperidine containing alpha -sulfonyl hydroxamic acid compounds have been prepared by this procedure. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)00835-8
• 作为产物：
  描述：

  N-Boc-4-哌啶甲酸甲酯 在 lithium hydroxide 、 草酰氯 、 N,N-二甲基甲酰胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 5.5h， 生成 tert-butyl 4-{[4-(2-butynyloxy)phenyl]sulfonyl}-4-[(hydroxyamino)carbonyl]-1-piperidinecarboxalate
  参考文献：
  名称：

  An efficient method to prepare α-sulfonyl hydroxamic acid derivatives

  摘要：

  alpha -Sulfonyl hydroxamic acid derivatives are biologically important molecules. An efficient protocol has bt en developed to mal;e these molecules via a direct sulfonylation of enolates. Several piperidine containing alpha -sulfonyl hydroxamic acid compounds have been prepared by this procedure. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(01)00835-8

文献信息

• Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/TACE inhibitors
  申请人：WYETH

  公开号：US20040229924A1

  公开（公告）日：2004-11-18

  Compounds of the formula: 1 useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

  该式的化合物：1在治疗关节炎、肿瘤转移、组织溃疡、异常伤口愈合、牙周病、骨病、糖尿病（胰岛素抵抗）和HIV感染方面有用。
• Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
  申请人：American Cyanamid Company

  公开号：US20020086890A1

  公开（公告）日：2002-07-04

  Compounds of the formula: 1 useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection.

  以下公式化合物：1，对于治疗关节炎、肿瘤转移、组织溃疡、异常伤口愈合、牙周疾病、骨疾病、糖尿病（胰岛素抵抗）和HIV感染非常有用。
• ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS
  申请人：Wyeth Holdings Corporation

  公开号：EP1147085B1

  公开（公告）日：2005-11-16
• US6753337B2
  申请人：——

  公开号：US6753337B2

  公开（公告）日：2004-06-22