2-(4-phenylpiperazin-1-yl)-5-[6-(4-phenylpiperazin-1-yl)pyrazin-2-yl][1,3,4]thiadiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(4-phenylpiperazin-1-yl)-5-[6-(4-phenylpiperazin-1-yl)pyrazin-2-yl][1,3,4]thiadiazole
• 英文别名: 2-(4-phenylpiperazin-1-yl)-5-[6-(4-phenylpiperazin-1-yl)pyrazin-2-yl]-1,3,4-thiadiazole
• 化学式: C₂₆H₂₈N₈S
• 分子量: 484.628
• InChiKey: STWQFEDVXRMSOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  92.8
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  6-chloropyrazine-2-carbamidrazone 在 氢氧化钾 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 20.5h， 生成 2-(4-phenylpiperazin-1-yl)-5-[6-(4-phenylpiperazin-1-yl)pyrazin-2-yl][1,3,4]thiadiazole
  参考文献：
  名称：

  Studies on Pyrazine Derivatives. 38. Synthesis, Reactions, and Tuberculostatic Activity of Pyrazinyl-substituted Derivatives of Hydrazinocarbodithioic Acid

  摘要：

  DOI：

  10.1023/b:cohc.0000048293.68655.d5

文献信息

• Reactivity of <i>N</i> ¹-Dithioester Substituted Pyridinand Pyrazincarboxamidrazones
  作者：Czeslawa Orlewska、Danuta Pancechowska-Ksepko、Henryk Foks、Zofia Zwolska、Ewa Augustynowicz-Kopec

  DOI：10.1080/10426500500270065

  日期：2006.4.1

  The N1-dithioester substituted pyridin- and pyrazincarboxamidrazones underwent cyclocondensation to 5-methylsulfanyl-1,3,4-thiadiazole or 1,2,4-triazole derivatives, depending on the reaction conditions. With an excess of secondary amines, pyrazincarboxamidrazone dithioester gave 5-amino-1,3,4-thiadiazoles and with an ethanoloamine a 1,2,4-triazole derivative. Prepared compounds were evaluated as potential tuberculostatic agents, but the minimum inhibitory concentrations values indicated no significant activity.
• Studies on Pyrazine Derivatives. 38. Synthesis, Reactions, and Tuberculostatic Activity of Pyrazinyl-substituted Derivatives of Hydrazinocarbodithioic Acid
  作者：H. Foks、I. Trapkowska、M. Janowiec、Z. Zwolska、E. Augustynowicz-Kopec

  DOI：10.1023/b:cohc.0000048293.68655.d5

  日期：2004.9