α-lithio methanesulfonate

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 英文名称: α-lithio methanesulfonate
• 化学式: C₃H₇LiO₃S
• 分子量: 130.094
• InChiKey: CKMVDGAUYGMGJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.38
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  35.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  丁酸乙酯 、 α-lithio methanesulfonate 以 四氢呋喃 为溶剂， 反应 3.5h， 生成 2-Oxo-pentane-1-sulfonic acid ethyl ester
  参考文献：
  名称：

  N-Sulfonyl homoserine lactones as antagonists of bacterial quorum sensing

  摘要：

  A series of 11 new analogues of N-acylhomoserine lactones in which the carboxamide bond was replaced by a sulfonamide one, has been synthesised. These compounds were evaluated for their ability to competitively inhibit the action of 3-oxohexanoyl-L-homoserine lactone, the natural ligand of the quorum sensing transcriptional regulator LuxR, which in turn activates expression of bioluminescence in the model bacterium Vibrio fischeri. Several compounds were found to display antagonist activity. Molecular modeling suggests that the latter prevent a cascade of structural rearrangements necessary for the formation of the active LuxR dimer. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.088

文献信息

• Water-soluble aminoxyls (nitroxides): 2-methyl-2-[(N-(4-tert-butylphenyl)oxyl]propanesulfonate and (1-oxyl-2,5,5-trimethylpyrrolidin-2-yl)methanesulfonate
  作者：Lucien Marx、André Rassat

  DOI：10.1039/b110766f

  日期：2002.3.7

  Two charged aminoxyls, ammonium (1-oxyl-2,5,5-trimethylpyrrolidin-2-yl)methanesulfonate and ammonium 2-methyl-2-[(N-(4-tert-butylphenyl)oxyl]propanesulfonate, obtained by methods easily adaptable to the preparation of various other aminoxyls are totally soluble in water but are partially associated in other solvents.

  两种带电荷的氨基羟基--(1-氧乙基-2,5,5-三甲基吡咯烷-2-基)甲烷磺酸铵和 2-甲基-2-[(N-(4-叔丁基苯基)氧乙基]丙烷磺酸铵，其制备方法很容易适用于制备其他各种氨基羟基，这两种氨基羟基完全溶于水，但部分溶于其他溶剂。