2-phenyl-3-furoic acid | 57697-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 2-phenyl-3-furoic acid
• 英文别名: 2-phenyl-furan-3-carboxylic acid；2-Phenyl-furan-3-carbonsaeure；2-Phenyl-furancarbonsaeure-(3)；2-Phenylfuran-3-carboxylic acid
• CAS: 57697-76-4
• 化学式: C₁₁H₈O₃
• 分子量: 188.183
• InChiKey: JFLHLECAMDNXRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenyl-3-furoic acid 、 叔丁醇 在 叠氮磷酸二苯酯 、 三乙胺 作用下， 以 甲苯 为溶剂， 反应 3.5h， 以68%的产率得到N-(2-phenyl-3-furyl)carbamic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of potential fungicides based on N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides

  摘要：

  An efficient synthesis of novel N-(3-furanyl)pyrrolecarboxamides and N-(3-furanyl)pyrazolecarboxamides is presented starting from furan-3-carboxylic acid. Two complementary strategies to 2-aryl-3-furanamines with directed ortho lithiation, functionalization of the 2-position, and subsequent cross-coupling reaction as key steps were developed. Acylation of these intermediates with appropriate acid chlorides led finally to the target compounds.

  DOI：

  10.1007/s00706-009-0187-6
• 作为产物：
  描述：

  2-苯基-3-乙氧甲酰呋喃 生成 2-phenyl-3-furoic acid
  参考文献：
  名称：

  Fujita, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1925, # 519, p. 4

  摘要：

  DOI：

文献信息

• A synthesis of 2-alkyl-3-furoic acids
  作者：Marcus A. Tius、Selvaraj Savariar

  DOI：10.1016/s0040-4039(00)89210-2

  日期：1985.1
• Jurasek, Adolf; Berecinova, Daniela; Cakrt, Miroslav, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 1, p. 215 - 224
  作者：Jurasek, Adolf、Berecinova, Daniela、Cakrt, Miroslav、Dandarova, Miloslava、Friedl, Zdenek、et al.

  DOI：——

  日期：——
• JURASEK, ADOLF;BERECINOVA, DANIELA;CAKRT, MIROSLAV;DANDAROVA, MILOSLAVA;F+, COLLECT. CZECHOSL. CHEM. COMMUN., 54,(1989) N, C. 215-224
  作者：JURASEK, ADOLF、BERECINOVA, DANIELA、CAKRT, MIROSLAV、DANDAROVA, MILOSLAVA、F+

  DOI：——

  日期：——
• NOVAK J. J. K., COLLECT. CZECH. CHEM. COMMUNS <CCCC-AK>, 1975, 50, NO 9, 2855-2860
  作者：NOVAK J. J. K.

  DOI：——

  日期：——
• CARBAZOLE DERIVATIVES AND ORGANIC LIGHT EMITTING DIODES COMPRISING THE SAME
  申请人：LIN Jin-Sheng

  公开号：US20130105767A1

  公开（公告）日：2013-05-02

  In an embodiment, a carbazole derivative is provided. The carbazole derivative has formula (I): In formula (I), Ar1 and Ar2 are, independently, substituted or unsubstituted phenyl, naphthalenyl or heteroaryl containing nitrogen, oxygen or sulfur, and R is hydrogen, methyl or t-butyl. In another embodiment, an organic light emitting diode including the carbazole derivative is provided.