(2-溴乙基)三甲硅烷 | 18156-67-7

• 物质功能分类: 化学试剂 - 有机试剂 - 硅烷
• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: (2-溴乙基)三甲硅烷
• 中文别名: 2-(三乙基硅烷基)溴乙烷；(2-溴乙基)三甲基硅烷
• 英文名称: (2-bromoethyl)trimethylsilane
• 英文别名: 2-Bromethyl-trimethylsilan；2-(trimethylsilyl)ethyl bromide；2-bromoethyl(trimethyl)silane
• CAS: 18156-67-7
• 化学式: C₅H₁₃BrSi
• mdl: MFCD03093623
• 分子量: 181.148
• InChiKey: HYRIFSNOTHOUQJ-UHFFFAOYSA-N

物化性质

• 沸点：
  64-65 °C(Press: 39 Torr)
• 密度：
  1.15
• 溶解度：
  可溶于氯仿、DMSO（少量）

计算性质

• 辛醇/水分配系数(LogP)：
  2.79
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 危险类别码：
  R34,R
• 危险品运输编号：
  UN 3265
• 海关编码：
  2931900090
• 安全说明：
  S26
• 包装等级：
  III
• 危险类别：
  3,8
• 危险性防范说明：
  P210,P233,P240,P241,P242,P243,P260,P264,P280,P301+P330+P331,P303+P361+P353,P304+P340,P305+P351+P338,P310,P363,P370+P378,P403+P235,P405,P501
• 危险性描述：
  H225,H314

SDS

(2-Bromoethyl)trimethylsilane (stabilized with Silver Revision number: 6
chip)
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: (2-Bromoethyl)trimethylsilane (stabilized with Silver chip)

Revision number: 6

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS
Category 3
Flammable liquids
HEALTH HAZARDS
Category 1C
Skin corrosion/irritation
Serious eye damage/eye irritation Category 1
ENVIRONMENTAL HAZARDS Not classified
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Danger
Flammable liquid and vapour
Hazard statements
Causes severe skin burns and eye damage
Precautionary statements:
[Prevention] Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
Keep container tightly closed.
Use explosion-proof electrical/ventilating/lighting equipment. Take precautionary
measures against ignition by the static discharge and the spark.
Do not breathe dust/fume/gas/mist/vapours/spray.
Wash hands thoroughly after handling.
Wear protective gloves/eye protection/face protection.
[Response] IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
breathing.
IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses,
if present and easy to do. Continue rinsing.
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse
skin with water/shower.
Wash contaminated clothing before reuse.
Immediately call a POISON CENTER or doctor/physician.
Store in a well-ventilated place. Keep cool.
[Storage]
Store locked up.
Silver chip)

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Section 2. HAZARDS IDENTIFICATION
[Disposal] Dispose of contents/container through a waste management company authorized by
the local government.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: (2-Bromoethyl)trimethylsilane (stabilized with Silver chip)
>98.0%(T)
Percent:
CAS Number: 18156-67-7
2-(Trimethylsilyl)ethyl Bromide (stabilized with NaHCO3)
Synonyms:
Chemical Formula: C5H13BrSi

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Immediately call a POISON CENTER or doctor/physician.
Skin contact: Remove/Take off immediately all contaminated clothing. Gently wash with plenty of
soap and water. Immediately call a POISON CENTER or doctor/physician.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing.Immediately call a POISON CENTER or
doctor/physician.
Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT
Ingestion:
induce vomiting.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Unsuitable extinguishing Solid streams of water
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
from the chemical:
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Keep containers cool by
spraying with water. Eliminate all ignition sources if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, Use extra personal protective equipment (self-contained breathing apparatus). Keep
protective equipment and people away from and upwind of spill/leak. Ensure adequate ventilation. Entry to non-
emergency procedures: involved personnel should be controlled around the leakage area by roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Absorb spilled material in dry sand or inert absorbent before recovering it into an
containment and cleaning airtight container. In case of large amount of spillage, contain a spill by bunding.
up: Adhered or collected material should be promptly disposed of, in accordance with
appropriate laws and regulations.
Prevention of secondary Remove all sources of ignition. Fire-extinguishing devices should be prepared in
hazards: case of a fire. Use spark-proof tools and explosion-proof equipment.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Silver chip)

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Section 7. HANDLING AND STORAGE
Technical measures: Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent generation of vapour or mist. Keep away from heat/sparks/open flame/hot
surfaces. -No smoking. Take measures to prevent the build up of electrostatic
charge. Use explosion-proof equipment. Wash hands and face thoroughly after
handling.
Use a closed system if possible. Use a ventilation, local exhaust if vapour or aerosol
will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
May develop pressure. Open carefully.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in an explosion-poof refregerator.
Store under inert gas.
Protect from moisture.
Store locked up.
Store away from incompatible materials such as oxidizing agents.
Heat-sensitive, Moisture-sensitive
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Half or full facepiece respirator, self-contained breathing apparatus(SCBA), supplied
air respirator, etc. Use respirators approved under appropriate government standards
and follow local and national regulations.
Hand protection: Impervious gloves.
Eye protection: Safety goggles. A face-shield, if the situation requires.
Skin and body protection: Impervious protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Liquid
Clear
Form:
Colour: Colorless - Slightly pale yellow
Odour: No data available
pH: No data available
Melting point/freezing point:No data available
Boiling point/range: No data available
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: 1.15
Solubility(ies):
[Water] No data available
[Other solvents] No data available

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Section 10. STABILITY AND REACTIVITY
Stable under proper conditions.
Chemical stability:
Possibility of hazardous No special reactivity has been reported.
reactions:
Conditions to avoid: Spark, Open flame, Static discharge
Incompatible materials: Oxidizing agents, Strong acids
Hazardous decomposition Carbon monoxide, Carbon dioxide, Hydrogen bromide, Silicon oxides
products:
Silver chip)

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Section 11. TOXICOLOGICAL INFORMATION
Acute Toxicity: No data available
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
No data available
NTP =
Reproductive toxicity: No data available

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
Crustacea: No data available
No data available
Algae:
Persistence / degradability: No data available
No data available
Bioaccumulative
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
Henry's Law No data available
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when
disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: 3: Flammable liquid.
Subsidiary risk: 8: Corrosive.
UN-No: 2924
Proper shipping name: Flammable liquid, corrosive, n.o.s.
Packing group: III

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.
Silver chip)

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  (2-溴乙基)三甲硅烷 在 三乙胺 作用下， 以 异丙醇 、 乙腈 为溶剂， 反应 16.0h， 生成 (2E,4E)-5-((2-(1H-indol-3-yl)ethyl)(2-(trimethylsilyl)ethyl)amino)penta-2,4-dienal
  参考文献：
  名称：

  锌代醛的分子内环加成反应实现了士的宁，去甲氟尿嘧啶，脱氢脱乙酰基苯甲酸和缬氨酸的合成

  摘要：

  描述了由色胺衍生的锌醛的碱基介导的分子内Diels-Alder环加成反应的完整过程。这项重要的复杂性转化过程可从市售起始原料仅三步即可提供许多吲哚单萜生物碱的四环核，并且在正氟尿嘧啶的短合成（五步），脱氢脱乙酰基苯甲酸（六步），瓦尔帕比星（七步）的短合成中发挥了关键作用。 ，和士的宁（六个步骤）。还讨论了该反应的合理机理可能性，产物令人惊讶地容易的二聚化，以及在特定条件下出乎意料的环还原以再生锌酮醛。

  DOI：

  10.1021/jo2020246
• 作为产物：
  描述：

  乙烯基三甲基硅烷 在 silica gel 、 三溴化磷 作用下， 以 二氯甲烷 为溶剂， 反应 0.67h， 以51%的产率得到(2-溴乙基)三甲硅烷
  参考文献：
  名称：

  硫醇盐化学：一种功能强大且用途广泛的合成工具，可将寡聚噻吩固定在金表面上/使其功能化

  摘要：

  描述了一系列带有2-氰基乙基（CNE），2-三甲基甲硅烷基乙基（TMSE）和乙酰基（Ac）保护的硫醇盐基团的四噻吩（4T）的合成和表征。这些不同的保护基的顺序切割允许制备用二茂铁和/或烷硫醇链衍生的4T。这些化合物的电化学行为已通过循环伏安法（CV）在溶液中进行了分析。二茂铁衍生的二硫醇4T 14和具有两个TMSE保护的硫醇盐基团的二硫醇4T 15已被固定在金表面上，作为单层，已通过CV，椭偏，接触角测量和X射线光电子能谱（XPS）进行了表征）。结果表明，分子14和以共轭体系相对于表面的水平取向将图15所示的结构双重嫁接。此外，在15个单层上应用其余保护的硫醇盐基团的脱保护/烷基化顺序可实现有效的后功能化。

  DOI：

  10.1002/chem.201003687
• 作为试剂：
  描述：

  1-oxide-4-(3-undecooxyphenyl)pyridine-1-ium 、 diethyl (3-aminopropyl)phosphonate 在 N,N-二异丙基乙胺 、 bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate 、 (2-溴乙基)三甲硅烷 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以44 mg的产率得到[3-({4-[3-(undecyloxy)phenyl]pyridin-2-yl}amino)propyl]phosphonic acid
  参考文献：
  名称：

  新規リゾホスファチジン酸誘導体

  摘要：

  本发明旨在提供特异作用于LPA4受体的化合物以及含有该化合物的药物组合物。本发明涉及具有LPA4受体激动剂作用的新型磷脂酰肌醇酸衍生物，对涉及LPA4受体引起的血管形成异常疾病、血管障碍疾病或相关症状的预防和/或治疗具有用处。此外，本发明还涉及含有该磷脂酰肌醇酸衍生物的药物组合物。【选择图】无

  公开号：

  JP2021080183A

文献信息

• Cyclic sulphamidite analogues of penicillanic acid
  作者：Bill K. Cuthbert、Gordon Lowe

  DOI：10.1039/c39890001702

  日期：——

  Diastereoisomeric analogues of penicillanic acid have been synthesised in which the β-lactam ring is replaced with the 2-oxo-1,2,3-oxathiazolidine (cyclic sulphamidite) ring; ring fusion greatly increases the chemical reactivity of the 2-oxo-1,2,3-oxathiazolidine ring to nucleophilic attack.

  合成了青霉酸的非对映异构体类似物，其中β-内酰胺环被2-氧代-1,2,3-氧代噻唑烷（环状亚磺酰胺）环取代；环稠合极大地增加了2-氧代-1,2,3-氧代噻唑烷环对亲核进攻的化学反应性。
• [EN] NOVEL SPIRO IMIDAZOLONES AS GLUCAGON RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS FOR THEIR USE<br/>[FR] NOUVELLES SPIRO-IMIDAZOLONES EN TANT QU'ANTAGONISTES DE RÉCEPTEUR DE GLUCAGON, COMPOSITIONS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2011119559A1

  公开（公告）日：2011-09-29

  The present invention relates to compounds of the general formula: wherein ring A, ring B, R1, R3, Z, L1, and L2 are selected independently of each other and are as defined herein, to compositions comprising the compounds, and to methods of using the compounds as glucagon receptor antagonists and for the treatment or prevention of type 2 diabetes and conditions related thereto.

  本发明涉及一般式化合物，其中环A、环B、R1、R3、Z、L1和L2彼此独立选择，并如本文所定义，涉及包含该化合物的组合物，以及使用该化合物作为胰高血糖素受体拮抗剂以及用于治疗或预防2型糖尿病及相关疾病的方法。
• New, Chiral Phase Transfer Catalysts for Effecting Asymmetric Conjugate Additions of α-Alkyl-α-cyanoacetates to Acetylenic Esters
  作者：Xisheng Wang、Masanori Kitamura、Keiji Maruoka

  DOI：10.1021/ja068119g

  日期：2007.2.1

  A new, chiral phase transfer catalyst has been designed for the development of a general and useful procedure on the hitherto unknown, asymmetric conjugate additions of α-substituted-α-cyanoacetates to acetylenic esters with high enantioselectivity and moderate E/Z selectivity.

  设计了一种新的手性相转移催化剂，用于开发一种通用且有用的方法，用于将 α-取代-α-氰基乙酸酯与炔酯的不对称共轭加成反应，具有高对映选择性和中等 E/Z 选择性。
• Organosilicon Compounds. Part V. Synthesis of N-(trimethylsilylalkyl) diamines and N-(trimethylsilylalkyl)-N′-(2-mercaptoethyl) diamines.
  作者：Shelby F. Thames、Laroy H. Edwards

  DOI：10.1039/j39680002339

  日期：——

  The title compounds were prepared by direct synthesis, in good yields. Diamines used include ethylenediamine, trimethylenediamine, piperazine, and N-(2-aminoethyl)aziridine. Structures of the unsymmetrically substituted diamines were proved by i.r. spectral data and unambiguous synthesis. The dihydrochlorides of a number of these compounds were also prepared.

  通过直接合成以高收率制备标题化合物。使用的二胺包括乙二胺，三亚甲基二胺，哌嗪和N-（2-氨基乙基）氮丙啶。通过红外光谱数据和明确的合成证明了不对称取代的二胺的结构。还制备了许多这些化合物的二盐酸盐。
• Studies on Unsaturated Organosilicon Compounds. II. Reactions and Properties of Vinyltrimethylsilane
  作者：Motonori Kanazashi

  DOI：10.1246/bcsj.28.44

  日期：1955.1

  or related unsaturated organosilicon compounds were discussed. A conjugated structure involving silicon-carbon double bond in which the silicon atom has an expanded valence shell was postulated for some of these reactions. Such a structure was further confirmed by the shift of νc=c in the absorption spectra of vinyltrimethylsilane.4) Polymerization reactions of this compound were studied and the steric

  1) 研究了乙烯基三甲基硅烷双键与氢、溴、氯、溴化氢和碘化物的加成反应，并给出了产物的性质。 2) 乙烯基-硅键被浓硫酸裂解，但与3)讨论了乙烯基、烯丙基或相关不饱和有机硅化合物的上述两个反应的反应机理。对于这些反应中的一些，假设了涉及硅-碳双键的共轭结构，其中硅原子具有扩展的价壳。乙烯基三甲基硅烷的吸收光谱中 νc=c 的位移进一步证实了这种结构。