sodium 2-{4-[2-(3,5-dichloro-2-methoxybenzamido)-ethyl]-phenyl}-propionate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: sodium 2-{4-[2-(3,5-dichloro-2-methoxybenzamido)-ethyl]-phenyl}-propionate
• 英文别名: Sodium;2-[4-[2-[(3,5-dichloro-2-methoxybenzoyl)amino]ethyl]phenyl]propanoate
• 化学式: C₁₉H₁₈Cl₂NO₄*Na
• 分子量: 418.252
• InChiKey: UYOSDXCCVOPPOL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.17
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,5-dichloro-2-methoxybenzoyl chloride 、 ethyl 2-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride 生成 sodium 2-{4-[2-(3,5-dichloro-2-methoxybenzamido)-ethyl]-phenyl}-propionate
  参考文献：
  名称：

  Hypoglycaemically and hypolipidaemically active derivatives of

  摘要：

  Phenylacetic acid derivatives of the formula ##STR1## wherein A is an aryl radical optionally substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino or aryloxy, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy, Y is a valency bond or an optionally branched alkylene radical containing up to 3 carbon atoms, and R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical, or a physiologically compatible salt or ester thereof, exhibit marked hypoglycaemic and hypolipidaemic activity.

  公开号：

  US04207341A1

文献信息

• US4207341A
  申请人：——

  公开号：US4207341A

  公开（公告）日：1980-06-10
• US4278680A
  申请人：——

  公开号：US4278680A

  公开（公告）日：1981-07-14
• Hypoglycaemically and hypolipidaemically active derivatives of
  申请人：Boehringer-Mannheim GmbH

  公开号：US04207341A1

  公开（公告）日：1980-06-10

  Phenylacetic acid derivatives of the formula ##STR1## wherein A is an aryl radical optionally substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino or aryloxy, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy, Y is a valency bond or an optionally branched alkylene radical containing up to 3 carbon atoms, and R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical, or a physiologically compatible salt or ester thereof, exhibit marked hypoglycaemic and hypolipidaemic activity.

  Phenylacetic acid derivatives of the formula ##STR1## wherein A is an aryl radical optionally substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino or aryloxy, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy, Y is a valency bond or an optionally branched alkylene radical containing up to 3 carbon atoms, and R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical, or a physiologically compatible salt or ester thereof, exhibit marked hypoglycaemic and hypolipidaemic activity.