3-(2-chloroethanesulfonyl)propionyl chloride | 61515-41-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 3-(2-chloroethanesulfonyl)propionyl chloride
• 英文别名: 3-(2-chloroethylsulphonyl)-propionyl chloride；Propanoyl chloride, 3-[(2-chloroethyl)sulfonyl]-；3-(2-chloroethylsulfonyl)propanoyl chloride
• CAS: 61515-41-1
• 化学式: C₅H₈Cl₂O₃S
• 分子量: 219.089
• InChiKey: KAKDHLJJBBJUHT-UHFFFAOYSA-N

物化性质

• 熔点：
  71-72 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• 沸点：
  377.7±27.0 °C(Predicted)
• 密度：
  1.441±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-chloroethanesulfonyl)propionyl chloride 生成 乙二醇双(3-胺丙基)醚
  参考文献：
  名称：

  Vinylsulphone hardeners

  摘要：

  提供了一般公式为[CH.sub.2 =CHSO.sub.2 CH.sub.2 CH.sub.2 (CONH).sub.x (CH.sub.2).sub.3 ].sub.2 --O(CH.sub.2 CH.sub.2 O).sub.y --的乙烯磺酮化合物，其中x为1或2，y为0或1到100的整数。这些化合物可作为亲水胶体的交联剂，特别适用于凝胶，凝胶以照相材料层的形式存在。

  公开号：

  US04104302A1
• 作为产物：
  描述：

  3-(2-chloroethanesulfonyl)propionic acid 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以90.2%的产率得到3-(2-chloroethanesulfonyl)propionyl chloride
  参考文献：
  名称：

  NOVEL HYDROPHILIC LINKERS AND LIGAND-DRUG CONJUGATES THEREOF

  摘要：

  亲水性连接剂对于将药物与细胞结合配体在配体-药物共轭物中连接起来是很有用的，比如抗体-药物共轭物。这种配体-药物共轭物包括一个能够结合到特定细胞群的细胞结合配体，以及一个通过亲水性连接剂连接到配体的药物。亲水性连接剂包括一个或多个使连接剂具有亲水性的亲水性基团。亲水性连接剂还可能在两个末端包括功能基团，分别用于与药物和细胞结合配体进行偶联。

  公开号：

  US20190125894A1

文献信息

• Sulfur containing vinyl amide cross-linking agents
  申请人：Ciba-Geigy AG

  公开号：US04120898A1

  公开（公告）日：1978-10-17

  New vinyl compounds of the general formula ##STR1## are provided, wherein A is --CO-- or --SO.sub.2 --, v is 0 or 1, w is 0 or an integer of 1 to 6, x is 0 or 1, y is 2 to 6 and z is 1 or 2, at least one of w and x x being a positive integer. The vinyl compounds are useful as cross-linking agents for hydrophylic colloids, especially for gelatine in gelatino silver halide emulsion layers and other layers in photographic material.

  提供了一般式为##STR1##的新乙烯化合物，其中A为--CO--或--SO.sub.2--，v为0或1，w为0或1到6的整数，x为0或1，y为2到6，z为1或2，至少其中一个w和x为正整数。这些乙烯化合物可用作水性胶体的交联剂，尤其适用于明胶在明胶银卤化物乳胶层和摄影材料中的其他层。
• Silver halide photographic light-sensitive material
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04460680A1

  公开（公告）日：1984-07-17

  A silver halide photographic light-sensitive material comprising a support having thereon at least one light-sensitive silver halide emulsion layer and a light-insensitive uppermost layer is disclosed. The light-insensitive uppermost layer has a melting time longer than that of the light-sensitive silver halide emulsion layer and the thickness of the light-insensitive uppermost layer is from 1.3 .mu.m to 5.0 .mu.m. The silver halide photographic light-sensitive material has an improved covering power and results in remarkably low degree of reticulation. Furthermore, when the material is used it results in a reduced amount of scum being formed in the processing solution.

  本发明揭示了一种银卤化物照相感光材料，包括具有至少一个感光银卤化物乳剂层和一个光不敏感的最上层的支撑。光不敏感的最上层的熔化时间比感光银卤化物乳剂层长，光不敏感最上层的厚度为1.3微米至5.0微米。该银卤化物照相感光材料具有改善的覆盖力，并且产生明显较低的网状纹理程度。此外，当使用该材料时，处理溶液中形成的污垢量减少。
• Silver halide photographic light-sensitive materials
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04476218A1

  公开（公告）日：1984-10-09

  A silver halide photographic light-sensitive material is described, which comprises a support, and at least one light-sensitive silver halide emulsion layer and an uppermost layer provided on at least one surface of the support, wherein the melting time of the uppermost layer is made greater than that of the light-sensitive silver halide emulsion layer. The material has good strength and produces a reduced amount of scum which normally occurs in the processing liquid during development processing.

  本文描述了一种银卤化物摄影感光材料，它包括支撑物、至少一层感光银卤化物乳剂层和位于支撑物至少一个表面上的最上层。其中，最上层的熔化时间大于感光银卤化物乳剂层的熔化时间。该材料具有良好的强度，并在显影处理期间产生的污渍量减少。
• Method of hardening gelatin using sulfonyl compounds
  申请人：Fujii Photo Film Co., Ltd.

  公开号：US04028320A1

  公开（公告）日：1977-06-07

  A method of hardening gelatin which comprises adding thereto a compound of the following general formula (I): ##STR1## in which Y.sub.1 is CH.sub.2 =CH--, ClCH.sub.2 --CH.sub.2 --, BrCH.sub.2 --CH.sub.2 --, CH.sub.3 COO--CH.sub.2 CH.sub.2 -- or ClCH.sub.2 COO--CH.sub.2 CH.sub.2 --, R.sub.1 and R.sub.2 are H or CH.sub.3, but both of them are not CH.sub.3 at the same time, and A is one of the following groups: ##STR2## in which both R.sub.3 and R.sub.4 were acyl groups or at least one of them is an acyl group other than when R.sub.3 and R.sub.4 form a benzotriazole ring, and when one of R.sub.3 and R.sub.4 is an acyl group, the other is H or an alkyl group containing at most 4 carbon atoms; and wherein in any case, R.sub.3 and R.sub.4 may form a saturated or unsaturated carbocyclic or heterocyclic ring in combination with the nitrogen atom to which they are attached; R.sub.5, R.sub.6 and R.sub.7 are alkyl groups containing at most 4 carbon atoms, and may form a saturated or unsaturated ring, or may form a bicyclo ring; X.sup.- is an acid anion; R.sub.8 and R.sub.9 are a saturated or unsaturated carbocyclic or heterocyclic ring which combine with the nitrogen atom to which they are attached; R.sub.10 is an alkyl or aryl group containing at most 6 carbon atoms; R.sub.11 is an alkyl group containing at most 3 carbon atoms; R.sub.12 is an alkyl, aryl or aralkyl group containing at most 7 carbons atoms; Y.sub.2 is CH.sub.2 =CH--, ClCH.sub.2 --CH.sub.2 --, Br--CH.sub.2 CH.sub.2 --, CH.sub.3 COO--CH.sub.2 CH.sub.2 --, or ClCH.sub.2 COO--CH.sub.2 CH.sub.2 --, and Y.sub.1 is as earlier defined.

  一种硬化明胶的方法，包括向其中添加以下通式(I)的化合物：##STR1## 其中，Y.sub.1是CH.sub.2 =CH--，ClCH.sub.2 --CH.sub.2 --，BrCH.sub.2 --CH.sub.2 --，CH.sub.3 COO--CH.sub.2 CH.sub.2 --或ClCH.sub.2 COO--CH.sub.2 CH.sub.2 --，R.sub.1和R.sub.2是H或CH.sub.3，但它们两个同时不是CH.sub.3，A是以下一种基团之一：##STR2## 其中，R.sub.3和R.sub.4均为酰基或至少其中一个是酰基，除非R.sub.3和R.sub.4形成苯并三唑环，当R.sub.3和R.sub.4中的一个是酰基时，另一个是H或含有最多4个碳原子的烷基基团；在任何情况下，R.sub.3和R.sub.4可以与它们附着的氮原子结合形成饱和或不饱和的碳环或杂环；R.sub.5、R.sub.6和R.sub.7是含有最多4个碳原子的烷基基团，可以形成饱和或不饱和的环，或者可以形成双环；X.sup.-是酸根离子；R.sub.8和R.sub.9是与它们附着的氮原子结合形成饱和或不饱和的碳环或杂环；R.sub.10是含有最多6个碳原子的烷基或芳基基团；R.sub.11是含有最多3个碳原子的烷基基团；R.sub.12是含有最多7个碳原子的烷基、芳基或芳基烷基基团；Y.sub.2是CH.sub.2 =CH--，ClCH.sub.2 --CH.sub.2 --，Br--CH.sub.2 CH.sub.2 --，CH.sub.3 COO--CH.sub.2 CH.sub.2 --或ClCH.sub.2 COO--CH.sub.2 CH.sub.2 --，其中Y.sub.1如前所述。
• Medium for electrophoresis
  申请人：Fuji Photo Film Co., Ltd.

  公开号：US04769408A1

  公开（公告）日：1988-09-06

  A medium for electrophoresis in the form of an aqueous gel comprising an acrylamide copolymer having at least one specifically selected constitutional repeating unit. This medium is preferably employable for analysis of bipolymers such as proteins.

  一种电泳介质，采用至少具有一个特定选定的构成重复单元的丙烯酰胺共聚物制成的水凝胶形式。该介质最好用于分析蛋白质等双聚物。