1,1,2,2,3,3,4,4,4-nonafluoro-butane-1-sulfonic acid 11-methyl-6,11-dihydro-5-thia-11-aza-benzo[a]fluoren-8-yl ester

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: 1,1,2,2,3,3,4,4,4-nonafluoro-butane-1-sulfonic acid 11-methyl-6,11-dihydro-5-thia-11-aza-benzo[a]fluoren-8-yl ester
• 英文别名: (11-methyl-6H-thiochromeno[4,3-b]indol-8-yl) 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
• 化学式: C₂₀H₁₂F₉NO₃S₂
• 分子量: 549.438
• InChiKey: UBXBQVSRZCLDIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  82
• 氢给体数：
  0
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  11-methyl-6,11-dihydro-5-thia-11-aza-benzo[a]fluoren-8-ol 、 全氟丁基磺酰氟 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 1,1,2,2,3,3,4,4,4-nonafluoro-butane-1-sulfonic acid 11-methyl-6,11-dihydro-5-thia-11-aza-benzo[a]fluoren-8-yl ester
  参考文献：
  名称：

  WO2006/47017

  摘要：

  公开号：

文献信息

• [EN] NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS<br/>[FR] NOUVEAUX DERIVES CONTENANT DES HETEROATOMES TETRACYCLIQUES MODULATEURS DES RECEPTEURS DES HORMONES STEROIDIENNES SEXUELLES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2006034090A1

  公开（公告）日：2006-03-30

  The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.

  本发明涉及新型四环杂原子含有衍生物，含有它们的药物组合物，它们在治疗由一个或多个性激素受体介导的疾病中的应用以及它们的制备方法。
• Novel tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
  申请人：Sui Zhihua

  公开号：US20060116415A1

  公开（公告）日：2006-06-01

  The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.

  本发明涉及新型四环杂原子含有衍生物，含有它们的制药组合物，它们在治疗由一个或多个性激素受体介导的疾病中的使用以及它们的制备方法。
• NOVEL TETRACYCLIC HETEROATOM CONTAINING DERIVATIVES USEFUL AS SEX STEROID HORMONE RECEPTOR MODULATORS
  申请人：SUI Zhihua

  公开号：US20080114048A1

  公开（公告）日：2008-05-15

  The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.

  本发明涉及新型四环杂原子含有衍生物，包含它们的药物组合物，它们在治疗由一个或多个性激素受体介导的疾病中的应用以及它们的制备方法。
• Tetracyclic heteroatom containing derivatives useful as sex steroid hormone receptor modulators
  申请人：Janssen Pharmaceutica N.V.

  公开号：US07338973B2

  公开（公告）日：2008-03-04

  The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.

  本发明涉及新型四环杂原子含有衍生物、含有它们的制药组合物、它们在治疗由一个或多个性激素受体介导的疾病中的使用以及它们的制备过程。
• EP1907394B1
  申请人：——

  公开号：EP1907394B1

  公开（公告）日：2011-06-29