3-methyl-5,6-dihydroimidazo<2,1-b>thiazole | 55114-48-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并噻唑类
• 英文名称: 3-methyl-5,6-dihydroimidazo<2,1-b>thiazole
• 英文别名: 3-Methyl-5,6-dihydroimidazo[2,1-b][1,3]thiazole
• CAS: 55114-48-2
• 化学式: C₆H₈N₂S
• mdl: MFCD00231574
• 分子量: 140.209
• InChiKey: GOXKEFJIGQQOOV-UHFFFAOYSA-N

物化性质

• 沸点：
  231.3±23.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methyl-5,6-dihydroimidazo<2,1-b>thiazole 在 三乙胺 作用下， 以 丙酮 、 乙腈 为溶剂， 反应 7.0h， 生成 1H-吡咯并[1,2-a]咪唑-5,7-二羧酸,1-[2-[(3-乙氧基-3-羰基-1-丙烯基)硫代]-1-甲基乙烯基]-2,3-二氢-,二乙基酯,(Z,Z)-
  参考文献：
  名称：

  1,3-Dipolar cycloaddition of 5,6-dihydroimidazo[2,1-b]thiazolium betaines

  摘要：

  5,6-Dihydroimidazo[2,1-b]thiazolium betaines were generated in situ from 3,7-disubstituted 5,6-dihydroimidazo[2,1-b]thiazolium bromides and triethylamine. The reaction of these imidazothiazolium betaines with acetylenic dipolarophiles, such as ethyl propiolate, dimethyl acetylenedicarboxylate, and dibenzoylacetylene, provided geometric cis,trans isomers containing 2,3-dihydro-1H-pyrrolo[1,2-a]imidazole. We have proposed a mechanism of this reaction that involves 1,3-dipolar cycloaddition, isomeric rearrangement, and then nucleophilic addition successively. The ratio of trans and cis isomers depended on the temperature and solvents. The stereoselectivity of trans isomers increased with increasing temperature and decreasing polarity of solvents.

  DOI：

  10.1021/jo00034a029
• 作为产物：
  描述：

  亚乙基硫脲 、 一氯丙酮 在 乙醇 作用下， 生成 3-methyl-5,6-dihydroimidazo<2,1-b>thiazole
  参考文献：
  名称：

  4'：5'-二氢乙二醛（2'：1'- 2：2：3）噻唑鎓盐和噻唑衍生物的紫外线吸收

  摘要：

  DOI：

  10.1039/jr9550002943

文献信息

• Imidazo[2,1-b]thiazole and thiazolo[3,2-a]-benzimidazole quaternary
  申请人：Pfizer Inc.

  公开号：US03954784A1

  公开（公告）日：1976-05-04

  7-Substituted imidazo[2,1-b]thiazolium and 9-substitutedthiazolo-[3,2-a]benzimidazolium salts as blood-sugar lowering agents and growth promotants.

  7-取代咪唑[2,1-b]噻唑和9-取代噻唑-[3,2-a]苯并咪唑盐作为降低血糖和促进生长的药物。
• Thiazoline derivative and use of the same
  申请人：Kubo Keiji

  公开号：US20070010528A1

  公开（公告）日：2007-01-11

  A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X′ is a bond or —N(R 5 )—; Y is a divalent hydrocarbon group which may be substituted; Y′ is a bond or —C(═O)—; ring A is a nitrogen-containing heterocycle which may be substituted; Z 1 and Z 3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z 2 is a bond or —N(R 6 )—; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

  提供一种由式（I）表示的噻唑啉衍生物：其中R是环烃基，可以被取代，或者是可以被取代的杂环基; X是键或二价链烃基，可以被取代; X'是键或-N(R5)-; Y是二价烃基，可以被取代; Y'是键或-C(═O)-; 环A是含氮杂环，可以被取代; Z1和Z3各自独立地是键或二价链烃基，可以被取代; Z2是键或-N(R6)-; B是下式表示的基团：该化合物可用作治疗血栓症的药物。
• DIPHENYL SUBSTITUTED ALKANES
  申请人：Ogawa Anthony

  公开号：US20100190761A1

  公开（公告）日：2010-07-29

  The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

  本发明提供了式I的化合物，该化合物是5-脂氧合酶激活蛋白抑制剂：式(I)。式I的化合物可用作抗动脉粥样硬化、抗哮喘、抗过敏、抗炎和细胞保护剂。
• THIAZOLINE DERIVATIVE AND USE OF THE SAME
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1669352A1

  公开（公告）日：2006-06-14

  A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X' is a bond or -N(R5)-; Y is a divalent hydrocarbon group which may be substituted; Y' is a bond or -C(=O)-; ring A is a nitrogen-containing heterocycle which may be substituted; Z1 and Z3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z2 is a bond or -N(R6)-; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

  式 (I) 所代表的噻唑啉衍生物： 其中 R 是可被取代的环烃基或可被取代的杂环基；X 是键或可被取代的二价链烃基；X'是键或-N(R5)-；Y 是可被取代的二价烃基；Y'是键或-C(=O)-； 环 A 是可被取代的含氮杂环； Z1 和 Z3 各自独立地是键或可被取代的二价链烃基； Z2 是键或-N(R6)-； 以及 B 是由式表示的基团： 本发明提供了一种可作为血栓形成治疗药物的药物。
• 4′: 5′-Dihydroglyoxalino(2′: 1′- 2: 3)thiazolium salts, and the ultraviolet light absorption of thiazole derivatives
  作者：Walter Wilson、R. Woodger

  DOI：10.1039/jr9550002943

  日期：——