2,3-噻吩二甲酰氯 | 63599-98-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 中文名称: 2,3-噻吩二甲酰氯
• 英文名称: thiophene-2,3-dicarbonyl chloride
• 英文别名: 2,3-Thiophenedicarbonyl dichloride
• CAS: 63599-98-4
• 化学式: C₆H₂Cl₂O₂S
• 分子量: 209.053
• InChiKey: RVJQBIOPEJBQSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  3-甲基噻吩 、 2,3-噻吩二甲酰氯 在 三氯化铝 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 18.0h， 以16%的产率得到3-Methyl-benzo[1,2-b;5,4-b']dithiophene-4,8-dione
  参考文献：
  名称：

  Synthesis and Cytotoxicity of Methyl-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione Derivatives

  摘要：

  2- and 3-Methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione and related derivatives were synthesized and evaluated in vitro by NCI against eight cancer types. Compounds 12-15 showed significant activity against melanoma, NCl-H23 non-small cell lung cancer, and MDA-MB-435 and MDA-N breast cancer cell lines; 2-hydroxymethyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene4,8-dione (13) showed the highest activity against melanoma (mean log GI(50) = -7.74) and the highest overall potency (mean log GI50 = -6.99). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00241-7
• 作为产物：
  描述：

  噻吩-2,3-二羧酸 在 五氯化磷 作用下， 反应 14.0h， 生成 2,3-噻吩二甲酰氯
  参考文献：
  名称：

  Galvez, Carmen; Garcia, Francisco; Garcia, Juan, Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 1103 - 1108

  摘要：

  DOI：

文献信息

• Galvez, Carmen; Garcia, Francisco; Garcia, Juan, Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 1103 - 1108
  作者：Galvez, Carmen、Garcia, Francisco、Garcia, Juan、Soldevila, Joan

  DOI：——

  日期：——
• MAC DOWELL D. W. H.; BALLAS F. L., J. ORG. CHEM. <JOCE-AH>, 1977, 42, NO 23, 3717-3720
  作者：MAC DOWELL D. W. H.、 BALLAS F. L.

  DOI：——

  日期：——
• GUANYLHYDRAZONE COMPOUNDS, COMPOSITIONS, METHODS OF MAKING AND USING
  申请人：Cytokine Pharmasciences, Inc.

  公开号：EP1778265A2

  公开（公告）日：2007-05-02
• Ultraviolet Absorbent and Heterocyclic Compound
  申请人：Amasaki Ichiro

  公开号：US20090239982A1

  公开（公告）日：2009-09-24

  An ultraviolet absorbent represented by the following Formula (1) or (6): wherein, Het 1 represents a monovalent five- or six-membered aromatic heterocyclic residue; X a and X b each independently represent a heteroatom; Y a to Y c each independently represent a heteroatom or a carbon atom; the ring formed from carbon atom, X a , X b , Y a to Y c may have a double bond at any position and has at least one fused ring; wherein, Het 6 represents a monovalent five- or six-membered aromatic heterocyclic residue; X 6a and X 6b each independently represent a heteroatom; Y 6a , Y 6b and Y 6c each independently represent a heteroatom or a carbon atom; L 6 represents a bi- to octa-valent connecting group; n is an integer of 2 or more, and m is an integer of 0 or more.
• [EN] GUANYLHYDRAZONE COMPOUNDS, COMPOSITIONS, METHODS OF MAKING AND USING<br/>[FR] COMPOSES DE GUANYLHYDRAZONE, COMPOSITIONS DE GUANYLHYDRAZONE, AINSI QUE LEURS METHODES DE FABRICATION
  申请人：CYTOKINE PHARMASCIENCES INC

  公开号：WO2006023586A2

  公开（公告）日：2006-03-02

  The present invention relates to compounds having the formula I: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of making.