β-naphthyl p-chlorophenyl sulphone | 117953-31-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: β-naphthyl p-chlorophenyl sulphone
• 英文别名: 2-[(4-chlorophenyl)sulfonyl]naphthalene；(4-chloro-phenyl)-[2]naphthyl sulfone；(4-Chlor-phenyl)-β-naphthyl-sulfon；(4-Chlor-phenyl)-[2]naphthyl-sulfon；4-Chlorophenyl 2-naphthyl sulfone；2-(4-chlorophenyl)sulfonylnaphthalene
• CAS: 117953-31-8
• 化学式: C₁₆H₁₁ClO₂S
• 分子量: 302.781
• InChiKey: GXGCJXNHQRVNAH-UHFFFAOYSA-N

物化性质

• 熔点：
  136 °C
• 沸点：
  493.9±28.0 °C(Predicted)
• 密度：
  1.352±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-萘磺酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 β-naphthyl p-chlorophenyl sulphone
  参考文献：
  名称：

  Meyer,H., Justus Liebigs Annalen der Chemie, 1923, vol. 433, p. 342

  摘要：

  DOI：

文献信息

• Aryldiazonium Salts and DABSO: A Versatile Combination for Three‐Component Sulfonylative Cross‐Coupling Reactions
  作者：Pritha Das、Subhodeep Das、Ranjan Jana

  DOI：10.1002/asia.202200085

  日期：2022.6

  A catalyzed synthesis of diarylsulfones with arylboronic acids and catalyst-free synthesis of arylvinyl and alkylvinyl sulfones from vinyl bronic acids or halides is reported.

  报道了用芳基硼酸催化合成二芳基砜和由乙烯基溴酸或卤化物无催化剂合成芳基乙烯基和烷基乙烯基砜。
• Triflic‐Acid‐Catalyzed Friedel‐Crafts Reaction for the Synthesis of Diaryl Sulfones
  作者：Alban Falconnet、Jan‐Dirk Arndt、A. Stephen K. Hashmi、Thomas Schaub

  DOI：10.1002/ejoc.202200477

  日期：2022.7.14

  The synthesis of diaryl sulfones derivatives through Friedel-Crafts sulfonylation was achieved by using trifluoromethanesulfonic acid as catalyst with arylsulfonyl chlorides and arenes at elevated temperatures. In this procedure, the catalyst and the surplus of arene may well be retrieved and recycled in further batches.

  采用三氟甲磺酸作为催化剂，芳基磺酰氯和芳烃在高温下通过傅克磺酰化合成二芳基砜衍生物。在这个过程中，催化剂和过量的芳烃可以很好地回收并在更多批次中循环使用。
• Isomerization-Free Sulfonylation and Its Application in the Synthesis of PHA-565272A
  作者：Thomas J. Fleck、Jiong Jack Chen、Cuong V. Lu、Kari J. Hanson

  DOI：10.1021/op050208a

  日期：2006.3.1

  FeCl3 catalyzed an isomerization-free Friedel-Crafts sulfonylation between 1-naphthalenesulfonyl chloride and halobenzenes. The coupled halide was then displaced using 35% hydrazine in DMSO to provide the Fischer indole precursor. Pure 5-chloro-2-pentanone was the key for a successful Grandberg modification of Fischer indole synthesis that effectively constructed both the indole core and side chain of the target molecule. The development of these methods enabled a rapid preparation of kilogram quantities of PHA-565272A.
• Yoshii, Yoshihiro; Ito, Akiyoshi; Hirashima, Tsuneaki, Journal of the Chemical Society. Perkin transactions II, 1988, p. 777 - 782
  作者：Yoshii, Yoshihiro、Ito, Akiyoshi、Hirashima, Tsuneaki、Shinkai, Seiji、Manabe, Osamu

  DOI：——

  日期：——
• Catalyst-Free Electrochemical Sulfonylation of Organoboronic Acids
  作者：Weiwei Yao、Kang Lv、Zixi Xie、Hui Qiu、Mengtao Ma

  DOI：10.1021/acs.joc.2c02690

  日期：2023.2.17