2-(4-哌啶基甲基)-3,4-二氢-1H-异喹啉 | 120848-56-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 中文名称: 2-(4-哌啶基甲基)-3,4-二氢-1H-异喹啉
• 英文名称: 2-Piperidin-4-ylmethyl-1,2,3,4-tetrahydro-isoquinoline
• 英文别名: 2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline；2-(piperidin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline；Isoquinoline, 1,2,3,4-tetrahydro-2-(4-piperidinylmethyl)-；2-(piperidin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline
• CAS: 120848-56-8
• 化学式: C₁₅H₂₂N₂
• mdl: MFCD00880881
• 分子量: 230.353
• InChiKey: GUFTZAHBWSLXTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-哌啶基甲基)-3,4-二氢-1H-异喹啉 生成 [4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)piperidin-1-yl]-phenylmethanone
  参考文献：
  名称：

  GEORGE, PASCAL;SEVRIN, MIREILLE;MALOIZEL, CHRISTIAN

  摘要：

  DOI：

文献信息

• Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
  申请人：——

  公开号：US20030166644A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物抑制激素敏感性脂肪酶，包括这些化合物的药物组合物，使用这些化合物和组合物的治疗方法，以及新化合物。目前的化合物是激素敏感性脂肪酶的抑制剂，可能在治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病中有用。
• Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1849781A1

  公开（公告）日：2007-10-31

  The present invention relates to substituted pyrrolidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animal.

  本发明涉及通式（I）的取代吡咯烷化合物，其制备方法，包含这些化合物的药物以及它们在制备用于治疗人类和动物的药物中的应用。
• 2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives,
  申请人：——

  公开号：US04885302A1

  公开（公告）日：1989-12-05

  A compound of formula (I) ##STR1## in which R is (a) a hydrogen atom; (b) a linear or branched (C.sub.1 -C.sub.6) alkyl group; an allyl group; a cycloalkylmethyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a phenylmethyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, amino, dimethylamino, cyano, aminocarbonyl, linear or branched (C.sub.1 -C.sub.3) alkyl, linear or branched (C.sub.1 -C.sub.3) alkoxy and linear or branched (C.sub.1 -C.sub.3) alkylthio groups; a 2-phenylethyl group; a 3-phenylpropyl group; a 3-phenyl-2-propenyl group; a phenylcarbonylmethyl group; a naphthylmethyl group; a pyridylmethyl group; a furylmethyl group; or a thienylmethyl group; or (c) a linear or branched (C.sub.2 -C.sub.6) alkanoyl group; a cycloalkylcarbonyl group in which the cycloalkyl moiety has from 3 to 6 carbon atoms; a trifluoroacetyl group; a phenyl-carbonyl group unsubstituted or substituted with one to three substituents chosen from halogen atoms and trifluoromethyl, nitro, linear or branched (C.sub.1 -C.sub.3) alkyl, linear or branched (C.sub.1 -C.sub.3) alkoxy and linear or branched (C.sub.1 -C.sub.3) alkylthio groups; a 1-oxo-3-phenyl-2-propenyl group; a naphthylcarbonyl group; a pyridylcarbonyl group; a furylcarbonyl group; a thienylcarbonyl group; a (2-indolyl)-carbonyl group; or a (5-indolyl)carbonyl group; or a pharmacologically acceptable acid addition salt thereof.

  化学式（I）的化合物##STR1##中，其中R是（a）氢原子；（b）线性或支链（C.sub.1-C.sub.6）烷基基团；烯丙基基团；环烷基甲基基团，其中环烷基部分具有3至6个碳原子；未取代或取代有来自卤素原子和三氟甲基、硝基、氨基、二甲胺基、氰基、氨基羰基、线性或支链（C.sub.1-C.sub.3）烷基、线性或支链（C.sub.1-C.sub.3）烷氧基和线性或支链（C.sub.1-C.sub.3）硫代烷基基团的苯甲基基团；2-苯乙基基团；3-苯基丙基基团；3-苯基-2-丙烯基基团；苯甲酰基基团；萘甲基基团；吡啶甲基基团；呋喃甲基基团；或噻吩甲基基团；或（c）线性或支链（C.sub.2-C.sub.6）烷酰基基团；环烷基羰基基团，其中环烷基部分具有3至6个碳原子；三氟乙酰基基团；未取代或取代有来自卤素原子和三氟甲基、硝基、线性或支链（C.sub.1-C.sub.3）烷基、线性或支链（C.sub.1-C.sub.3）烷氧基和线性或支链（C.sub.1-C.sub.3）硫代烷基基团的苯羰基基团；1-氧代-3-苯基-2-丙烯基基团；萘羰基基团；吡啶羰基基团；呋喃羰基基团；噻吩羰基基团；（2-吲哚基）-羰基基团；或（5-吲哚基）羰基基团；或其药理学上可接受的酸盐。
• Use of compounds for decreasing activity of hormone-sensitive
  申请人：——

  公开号：US20030166690A1

  公开（公告）日：2003-09-04

  Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.

  使用化合物来抑制激素敏感性脂肪酶，包括这些化合物的制药组合物，使用这些化合物和组合物的治疗方法，以及新颖的化合物。这些化合物是激素敏感性脂肪酶的抑制剂，可用于治疗和/或预防需要降低激素敏感性脂肪酶活性的医学疾病。
• 5-Ht7 Receptor Antagonists
  申请人：Torrens Jover Antoni

  公开号：US20080214603A1

  公开（公告）日：2008-09-04

  The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

  本发明涉及具有对5-HT7受体的药理活性的化合物，更具体地涉及一些四氢异喹啉取代磺酰胺化合物，以及制备这些化合物的方法，包括它们的药物组成物，以及它们用于治疗和/或预防5-HT参与的疾病，如中枢神经系统疾病的用途。