Ph3GeCH(p-CH3OC6H4)CH2COOH | 146139-05-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: Ph3GeCH(p-CH3OC6H4)CH2COOH
• 英文别名: 3-(4-Methoxyphenyl)-3-triphenylgermylpropanoic acid
• CAS: 146139-05-1
• 化学式: C₂₈H₂₆GeO₃
• 分子量: 483.103
• InChiKey: BKHAILVUDSWBGO-UHFFFAOYSA-N

物化性质

• 沸点：
  593.8±60.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.96
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Ph3GeCH(p-CH3OC6H4)CH2COOH 、 三(对甲基苯基)二溴化锑 在 NEt₃ 作用下， 以 甲苯 为溶剂， 以81%的产率得到[Ph3GeCH(p-CH3OC6H4)CH2COO]2(antimony)(p-CH3C6H4)3
  参考文献：
  名称：

  Synthesis, Spectral and In Vitro Biological Studies of Bis‐Triorganogermyl(substituted)propionates of Triarylantimony(V) X‐ray Studies of Triphenylgermyl‐n‐propyl Propionic Acid

  摘要：

  New compounds of Bis-triorganogermyl(substituted) propionates of triarylantimony(V) with general formula (R-1(3)-(GeCHRCH2CO2)-C-2) 2SbAr3 have been synthesized and characterized by various techniques such as elemental analyses; FT-IR, (HNMR)-H-1, (CNMR)-C-13 and mass spectrometry. All these compounds have distorted trigonal bipyramidal geometry around antimony in both solid states as well as in non-coordinated solvents. The single X-ray analysis of precursor triphenylgermyl-n-propyl propionic acid (Ph3GeCH-(n-C3H7)CH2COOH) have revealed dimeric structure of molecule through strong hydrogen bonding in conventional manner in which germanium has slightly distorted tetrahedral geometry. Selected numbers of compounds screened against different strains of bacteria and fungus show good activity.

  DOI：

  10.1080/15533170600862903

文献信息

• Synthesis and structural characterization of several tris(2-methyl-2-phenylpropyl)tin carboxylates containing germanium
  作者：Xiaoniu Fang、Xueqing Song、Qinglan Xie

  DOI：10.1016/s0022-328x(00)00542-8

  日期：2001.1

  Thirteen tris(2-methyl-2-phenylpropyl)tin germylpropionates have been synthesized and their structures characterized by elemental analysis, IR, multinuclear NMR (1H, 13C, 119Sn) and MS spectroscopies. The structure of (PhC(CH3)2CH2)3SnO2CCH2CH(o-C6H4Cl)GePh3 has been determined by X-ray diffraction study, which indicated that the tin in the compound possess a tetrahedral geometry. Bioassay results

  合成了十三种三（2-甲基-2-苯基丙基）锡三甲基丙酸酯，并通过元素分析，IR，多核NMR（1 H，13 C，119 Sn）和MS光谱学对其结构进行了表征。通过X射线衍射研究确定了（PhC（CH 3）2 CH 2）3 SnO 2 CCH 2 CH（o -C 6 H 4 Cl）GePh 3的结构，表明该化合物中的锡具有四面体几何。生物测定结果表明，某些化合物具有良好的杀螨活性。
• Synthesis, structures and in vitro antitumor activity of some germanium-substituted di-n-butyltin dipropionates
  作者：Song Xueqing、Yang Zhiqiang、Xie Qinglan、Li Jinshan

  DOI：10.1016/s0022-328x(98)00607-x

  日期：1998.9