methyl (2,5-dimethylthiophen-3-yl)acetate | 118488-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: methyl (2,5-dimethylthiophen-3-yl)acetate
• 英文别名: methyl 2,5-dimethyl-3-thienylacetate；methyl 2-(2,5-dimethylthiophen-3-yl)acetate
• CAS: 118488-10-1
• 化学式: C₉H₁₂O₂S
• 分子量: 184.259
• InChiKey: GXUSFZWFMINJFP-UHFFFAOYSA-N

物化性质

• 沸点：
  246.9±35.0 °C(Predicted)
• 密度：
  1.121±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl (2,5-dimethylthiophen-3-yl)acetate 在 ammonium hydroxide 、 四氯化锡 作用下， 以 二氯甲烷 为溶剂， 反应 122.0h， 生成 2,5-dimethyl-4-acetyl-3-thiopheneacetamide
  参考文献：
  名称：

  Press, Jeffery B.; McNally, James J., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1571 - 1581

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2,5-dimethyl-3-thienyl)-1-morpholino-1-thioxoethane 在 sodium hydroxide 、 硫酸 作用下， 以 甲醇 为溶剂， 反应 7.0h， 生成 methyl (2,5-dimethylthiophen-3-yl)acetate
  参考文献：
  名称：

  Press, Jeffery B.; McNally, James J., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1571 - 1581

  摘要：

  DOI：

文献信息

• Thienopyridines useful as cardiovascular agents
  申请人：Ortho Pharmaceutical Corporation

  公开号：US04775757A1

  公开（公告）日：1988-10-04

  The synthesis of thienopyridine derivatives is described. The novel thienopyridine derivatives are cardiotonic agents and renal vasodilating agents. The compounds are useful as cardiovascular agents.

  本文描述了噻吩并吡啶衍生物的合成。这些新型噻吩并吡啶衍生物是心脏强效药和肾脏扩血管剂。这些化合物可用作心血管药物。
• NEW COMPOUNDS FOR THE TREATMENT OF CNS DISORDERS
  申请人：GIOVANNINI Riccardo

  公开号：US20110082137A1

  公开（公告）日：2011-04-07

  The invention relates to novel 1,6-disubstituted pyrazolopyrimidinones of formula (I), in which Hc is a tetrahydropyranyl-group and R 1 is the group V—W−*, whereby V and W independently of each other may be an aryl group or an heteroaryl group, which independently of each other may optionally be substituted. According to one aspect of the invention the new compounds are for use as medicaments or for the manufacture of medicaments, in particular medicaments for the treatment of conditions concerning deficits in perception, concentration, learning or memory. The new compounds are also for the manufacture of medicaments and/or for use in the treatment of e.g. Alzheimer's disease, in particular for cognitive impairment associated with Alzheimer's disease.

  本发明涉及一种新型的1,6-二取代吡唑嘧啶酮化合物，其化学式为（I），其中Hc为四氢吡喃基团，R1为V-W−*基团，其中V和W各自独立地可以是芳基基团或杂环基团，可以选择地进行取代。根据本发明的一个方面，这些新化合物可用作药物或制药用途，特别是用于治疗与感知、注意力、学习或记忆缺陷有关的疾病。这些新化合物还可用于制药或用于治疗例如阿尔茨海默病等疾病，特别是用于与阿尔茨海默病相关的认知障碍的治疗。
• ——
  作者：M. M. Krayushkin、V. Z. Shirinian、L. I. Belen"kii、A. Yu. Shadronov

  DOI：10.1023/a:1020975326034

  日期：——

  A procedure was developed for the synthesis of symmetrical and unsymmetrical cyclobutene-1,2-dione derivatives bearing thiophene and thieno[3,2-b]thiophene substituents by the Friedel-Crafts reaction of the corresponding heterocyclic compounds with squaric acid dichloride in the presence of AlCl3 In addition to the target dihetaryl-cyclobutenediones, monoacylation products of methyl (2,5-dimethylthiophen-3-yl)acetate and methyl 5-methylthieno[3,2-blthiophene-2-carboxylate with squaric acid dichloride were isolated and characterized.
• PRESS, JEFFERY B.;MCNALLY, JAMES J., J. HETEROCYCL. CHEM., 25,(1988) N, C. 1571-1581
  作者：PRESS, JEFFERY B.、MCNALLY, JAMES J.

  DOI：——

  日期：——
• Biomedical devices having improved surface characteristics
  申请人：Winterton Lynn Cook

  公开号：US20080129956A1

  公开（公告）日：2008-06-05

  Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.