1-(4-苄氧苯基)哌嗪盐酸盐 | 321132-21-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-(4-苄氧苯基)哌嗪盐酸盐
• 英文名称: 1-(4-benzyloxyphenyl)-piperazine hydrochloride
• 英文别名: 1-(4-Benzyloxy-phenyl]-piperazine hydrochloride；1-(4-benzyloxy-phenyl)-piperazine hydrochloride；1-[4-(Benzyloxy)phenyl]piperazine hydrochloride；1-(4-phenylmethoxyphenyl)piperazine;hydrochloride
• CAS: 321132-21-2
• 化学式: C₁₇H₂₀N₂O*ClH
• 分子量: 304.82
• InChiKey: NQIOJWRWPRUPIZ-UHFFFAOYSA-N

物化性质

• 熔点：
  210℃

计算性质

• 辛醇/水分配系数(LogP)：
  -1.35
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  9-(4-溴丁基)-N-(2,2,2-三氟乙基)-9H-芴-9-甲酰胺 、 1-(4-苄氧苯基)哌嗪盐酸盐 生成 9-{4-[4-(4-Benzyloxy-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide
  参考文献：
  名称：

  Substituted piperazine derivatives, the preparation thereof and their use as medicaments

  摘要：

  本发明涉及一般式中Ra、Rb、Rc、Rf、Rg和m、n和X如权利要求1中所定义的取代哌嗪衍生物，其异构体和盐，特别是其生理上可接受的盐，这些化合物是微粒体三酰甘油转移蛋白（MTP）的有价值的抑制剂，包含这些化合物的药物以及它们的用途，以及它们的制备。

  公开号：

  US06818644B1
• 作为产物：
  描述：

  tert-butyl 4-(4-benzyloxyphenyl)piperazine-1-carboxylate 、 盐酸 以 1,4-二氧六环 为溶剂， 生成 1-(4-苄氧苯基)哌嗪盐酸盐
  参考文献：
  名称：

  BIARYL NITROGEN-HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION

  摘要：

  本发明涉及一种化学类别的双芳基氮连接杂环化合物，它们是LTA4H（白三烯A4水解酶）的抑制剂。这些化合物具有以下通式： 它们对治疗、预防和预防炎症性疾病和紊乱非常有用。

  公开号：

  US20070149544A1

文献信息

• BIARYL NITROGEN-HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
  申请人：SANDANAYAKA Vincent

  公开号：US20070149544A1

  公开（公告）日：2007-06-28

  The present invention relates to a chemical genus of biaryl nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

  本发明涉及一种化学类别的双芳基氮连接杂环的化合物，它们是LTA4H（白三烯A4水解酶）的抑制剂。这些化合物具有下列的一般式：它们可用于治疗、预防和预防炎症性疾病和疾患。
• Sulfonyl Amino Cyclic Derivatives and Use Thereof
  申请人：Swinnen Dominique

  公开号：US20080194520A1

  公开（公告）日：2008-08-14

  The present invention is related to derivatives of Formula (I) and use thereof in particular for the treatment and/or prophylaxis of autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, cancer, respiratory diseases and fibrosis, including multiple sclerosis, arthritis, emphysema, chronic obstructive pulmonary disease, liver and pulmonary fibrosis.

  本发明涉及公式（I）的衍生物及其在特定疾病的治疗和/或预防中的应用，特别是在自身免疫性疾病、炎症性疾病、心血管疾病、神经退行性疾病、癌症、呼吸系统疾病和纤维化等方面的应用，包括多发性硬化症、关节炎、肺气肿、慢性阻塞性肺疾病、肝纤维化和肺纤维化。
• Indolebutylamines as Selective 5-HT_1A Agonists
  作者：Timo Heinrich、Henning Böttcher、Gerd D. Bartoszyk、Hartmut E. Greiner、Christoph A. Seyfried、Christoph van Amsterdam

  DOI：10.1021/jm040792y

  日期：2004.9.1

  A series of new 1-[4-(indol-3-yl)butyl]-4-arylpiperazines was prepared to identify highly selective and potent 5-HT1A agonists as potential pharmacological tools in studies of mood disorders. The combination of structural elements (indole-alkyl-amine and aryl-piperazine) known to introduce 5-HT1A receptor affinity and the proper selection of substituents (R on the indole moiety and R' on the aryl moiety) led to compounds with high receptor specificity and affinity. In particular, the introduction of the methyl ether or the unsubstituted carboxamide as substituents in position 5 of the indole (R) guaranteed serotonergic 5-HT1A affinity compared to the unsubstituted analogue. Para-substituted arylpiperazines (R') decreased dopaminergic D-2 binding and increased selectivity for the 5-HT1A receptor. Agonistic 5-HT1A receptor activity was confirmed in vivo in the ultrasonic vocalization test, and the results suggest that the introduction of the carboxamide residue leads to better bioavailability than the corresponding methyl ether. 3-4-[4-(4-Carbamoylphenyl)piperazin-1-yl}butyl}-1H-indole-5-carboxamide 54 was identified as a highly selective 5-HT1A receptor agonist [GTPgammaS, ED50 = 4.7 nM] with nanomolar 5-HT1A affinity [IC50 = 0.9 nM] and selectivity [D-2, IC50 > 850 nM]. 3-4-[4-(4-Methoxyphenyl)piperazin-1-yl]butyl}-1H-indole-5-carboxamide 45 is one of the most potent and selective 5-HT1A agonists known [5-HT1A, IC50 = 0.09 nM; D-2, IC50 = 140 nM].
• Fast deprotection of phenoxy benzyl ethers in transfer hydrogenation assisted by microwave
  作者：Monica Quai、Claudio Repetto、Walter Barbaglia、Enzo Cereda

  DOI：10.1016/j.tetlet.2006.12.041

  日期：2007.2

  Phenoxy benzyl ethers are easily and quickly deprotected in the presence of ammonium formate and microencapsulated Pd(0)EnCat with the assistance of microwave irradiation. This procedure can be applied in the presence of other functional groups as well. The described protocol is particularly convenient for the preparation in a parallel and automatic fashion of libraries of compounds possessing a phenol type moiety. (c) 2006 Elsevier Ltd. All rights reserved.
• SUBSTITUIERTE PIPERAZINDERIVATE, IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS INHIBITOREN DES MIKROSOMALEN TRIGLYZERID-TRANSFERPROTEINS (MTP)
  申请人：Boehringer Ingelheim Pharma KG

  公开号：EP1228053A1

  公开（公告）日：2002-08-07