phosphoric acid mono(2-naphth-2-yl)ethyl ester mono(triethylammonium) salt | 1301120-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: phosphoric acid mono(2-naphth-2-yl)ethyl ester mono(triethylammonium) salt
• CAS: 1301120-98-8
• 化学式: C₆H₁₅N*C₁₂H₁₃O₄P
• 分子量: 353.398
• InChiKey: KUEHDGBUUBFTCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.84
• 重原子数：
  24.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  70.0
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  phosphoric acid mono(2-naphth-2-yl)ethyl ester mono(triethylammonium) salt 、 triethylammonium 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranose-1-yl phosphate 在 吡啶 、 三聚氯氰 、 magnesium bromide 作用下， 以 乙腈 为溶剂， 反应 49.75h， 以25%的产率得到P1-3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-α-D-glucopyranosyl-P2-[2-(naphth-2-yl)ethyl] diphosphate di(ammonium salt)
  参考文献：
  名称：

  Diphosphate formation using cyanuric chloride or triisopropylbenzenesulfonyl chloride as the activating agents

  摘要：

  By using cyanuric chloride or 2,4,6-triisopropylbenzenesulfonyl chloride (TIPSCl) as the condensing agent and magnesium bromide as the promoter, the phosphate cross-coupling reactions are effectively carried out to give lipid-saccharide and pyrrolidine-guanosine diphosphates. Under optimized conditions, the TIPSCl-facilitated cross-coupling reactions complete in a short reaction time (similar to 5 h) without the complication of possible self-coupling reactions. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.034