1-Methyl-naphthalin-4-sulfonsaeure | 14927-61-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Methyl-naphthalin-4-sulfonsaeure
• 英文别名: 4-Methyl-1-naphthalenesulfonic acid；4-methylnaphthalene-1-sulfonic acid
• CAS: 14927-61-8
• 化学式: C₁₁H₁₀O₃S
• 分子量: 222.265
• InChiKey: ZTDJDNLZVGJTBW-UHFFFAOYSA-N

物化性质

• 密度：
  1.366±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  62.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Methyl-naphthalin-4-sulfonsaeure 生成 4-甲基-1-萘
  参考文献：
  名称：

  Elbs; Christ, Journal fur praktische Chemie (Leipzig 1954), 1923, vol. <2> 106, p. 23

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基萘 在 硫酸 作用下， 生成 1-Methyl-naphthalin-4-sulfonsaeure
  参考文献：
  名称：

  Elbs; Christ, Journal fur praktische Chemie (Leipzig 1954), 1923, vol. <2> 106, p. 23

  摘要：

  DOI：

文献信息

• METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY
  申请人：VOHRA Rahul

  公开号：US20090082368A1

  公开（公告）日：2009-03-26

  Disclosed are compositions which modulate the interaction with nerve growth factor and precursors thereof with neurotrophic receptors. Also disclosed are methods of using the compositions of the invention, including methods of administration.

  揭示了一种调节神经生长因子及其前体与神经营养受体相互作用的组合物。还揭示了使用该发明的组合物的方法，包括给药方法。
• Catalytic activity of aminomethylated calix[4]resorsinolarene aggregates in hydrolysis of esters of phosphorus acids
  作者：I. S. Ryzhkina、L. A. Kudryavtseva、Ya. A. Babkina、K. M. Enikeev、M. A. Pudovik、A. I. Konovalov

  DOI：10.1007/bf02495076

  日期：2000.8

  aminomethylated calix[4]resorcinolarenes (AMC) withp-nitrophenyl esters of phosphorus acids (EPA) in a water—DMF solution (30 vol.% DMF) was studied by spectrophotometry and31P NMR spectroscopy in the presence and absence of the nonionic surfactant Triton X-100. The AMC form aggregates of micellar and nonmicellar types and are the catalysts for EPA hydrolysis. The catalytic activity of the aggregates depends on

  通过分光光度法和 31 P NMR 光谱研究了氨基甲基化杯[4]间苯二酚 (AMC) 与磷酸的对硝基苯酯 (EPA) 在水-DMF 溶液 (30 vol.% DMF) 中的反应动力学。非离子表面活性剂 Triton X-100。AMC 形成胶束和非胶束类型的聚集体，是 EPA 水解的催化剂。聚集体的催化活性取决于它们的结构、介质的 pH 值和溶剂的性质。
• 5-HT7 receptor antagonists
  申请人：Torrens Jover Antoni

  公开号：US20060040978A1

  公开（公告）日：2006-02-23

  The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

  这项发明涉及具有对5-HT7受体具有药理活性的化合物，更特别地涉及一些四氢异喹啉取代磺胺基化合物，以及制备这些化合物的过程，包括含有它们的药物组合物，并且用于治疗和/或预防涉及5-HT的疾病，如中枢神经系统紊乱。
• Fluorosurfactants
  申请人：Hierse Wolfgang

  公开号：US20100152081A1

  公开（公告）日：2010-06-17

  The invention relates to compounds comprising an aryl sulfonate group, a spacer and a Y group, wherein Y represents CF 3 —(CH 2 ) a —O—, SF 5 —, CF 3 —(CH 2 ) a —S—, CF 3 CF 2 S—, [CF 3 —(CH 2 ) a ] 2 N— or [CF 3 —(CH 2 ) a ]NH—, a represents a whole number selected from the range of 0 to 5 or (formula I), Rf represents CF 3 —(CH 2 ) r —, CF 3 —(CH 2 ) r —O—, CF 3 —(CH 2 ) r —S—, CF 3 CF 2 —S—, SF 5 —(CH 2 ) r — or [CF 3 —(CH 2 ) r ] 2 N—, [CF 3 —(CH 2 ) r ]NH— or (CF 3 ) 2 N—(CH 2 ) r —, B represents a simple bond, O, NH, NR, CH 2 , C(O)—O, C(O), S, CH 2 —O, O—C(O), N—C(O)1C(O)—N, O—C(O)—N, N—C(O)—N, O—SO 2 or SO 2 —O, R represents alkyl having 1 to 4 C-atoms, b represents 0 or 1 and c represents 0 or 1, q represents 0 or 1, at least one radical from b and q represents 1, and r represents 0, 1, 2, 3, 4 or 5. The invention also relates to a method for the production of said compounds and to the uses of said surface-active compounds.

  本发明涉及一种化合物，其包括苯基磺酸酯基、间隔基和Y基，其中Y代表CF3—(CH2)a—O—、SF5—、CF3—(CH2)a—S—、CF3CF2S—、[CF3—(CH2)a]2N—或[CF3—(CH2)a]NH—，a代表从0到5的整数或（公式I），Rf代表CF3—(CH2)r—、CF3—(CH2)r—O—、CF3—(CH2)r—S—、CF3CF2—S—、SF5—(CH2)r—或[CF3—(CH2)r]2N—、[CF3—(CH2)r]NH—或(CF3)2N—(CH2)r—，B代表简单键、O、NH、NR、CH2、C(O)—O、C(O)、S、CH2—O、O—C(O)、N—C(O)1C(O)—N、O—C(O)—N、N—C(O)—N、O—SO2或SO2—O，R代表具有1至4个碳原子的烷基，b代表0或1，c代表0或1，q代表0或1，b和q中至少有一个基团为1，r代表0、1、2、3、4或5。本发明还涉及一种制备该化合物的方法以及该表面活性化合物的用途。
• Substituted tetrahydroisoquinoline compounds, their preparation and use in medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1837332A1

  公开（公告）日：2007-09-26

  The present invention relates to substituted tetrahydroisoquinoline compounds of general formula I, a process for their preparation, medicaments comprising said substituted tetrahydroisoquinoline compounds as well as the use of said substituted tetrahydroisoquinoline compounds for the preparation of medicaments, which are particularly suitable for the prophylaxis and/or treatment of disorders or diseases that are at least partially mediated via 5-HT6 receptors.

  本发明涉及通式I的取代四氢异喹啉化合物，其制备方法，包含所述取代四氢异喹啉化合物的药物以及使用所述取代四氢异喹啉化合物制备药物，这些药物特别适用于预防和/或治疗部分通过5-HT6受体介导的疾病或紊乱。