N,2,3,4,5,6-hexamethylaniline

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,2,3,4,5,6-hexamethylaniline
• 英文别名: 2,3,4,5,6,N-hexamethyl-aniline；6-Methylamino-1.2.3.4.5-pentamethyl-benzol；2,3,4,5,6,N-Hexamethyl-anilin
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: SZQRFZICTQQBGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  五甲基苯 、 N-methyl-O-tosylhydroxylamine 在 air 作用下， 反应 36.0h， 以97%的产率得到N,2,3,4,5,6-hexamethylaniline
  参考文献：
  名称：

  无金属直接芳烃 C−H 胺化

  摘要：

  通过形成 CN 键合成芳胺是制备功能材料、活性药物成分和生物活性产品的重要工具。通常，这种化学连接只能通过过渡金属催化的反应、光化学或电化学来实现。在这里，我们报告了在良性条件下使用羟胺衍生物进行的无金属芳烃 C-H 胺化。即使在存在各种官能团的情况下，胺化试剂 TsONHR 和芳烃底物之间的电荷转移相互作用也能实现芳烃的化学选择性胺化。氧气对于有效转化至关重要，其对电子转移步骤的加速作用已通过实验证明。此外，

  DOI：

  10.1002/adsc.202100236

文献信息

• Hofmann,A.W., Chemische Berichte, 1885, vol. 18, p. 1821
  作者：Hofmann,A.W.

  DOI：——

  日期：——
• CONDUCTIVE POLYMER, CONDUCTIVE POLYMER COMPOSITION, CONDUCTIVE POLYMER ORGANIC FILM, AND ORGANIC PHOTOELECTRIC DEVICE INCLUDING THE SAME
  申请人：Huh Dal-Ho

  公开号：US20110253946A1

  公开（公告）日：2011-10-20

  A conductive polymer, a conductive polymer composition, a conductive polymer organic film, and an organic photoelectric device including the same, the conductive polymer including repeating units represented by the following Chemical Formula 1, repeating units represented by the following Chemical Formula 2, and repeating units represented by the following Chemical Formula 3:
• CONDUCTIVE POLYMER, CONDUCTIVE POLYMER COMPOSITION, CONDUCTIVE POLYMER LAYER, AND ORGANIC PHOTOELECTRIC DEVICE INCLUDING THE CONDUCTIVE POLYMER LAYER
  申请人：HUH Dal-Ho

  公开号：US20120326094A1

  公开（公告）日：2012-12-27

  A conductive polymer, a conductive polymer composition, a conductive polymer layer, and an organic photoelectric device including the conductive polymer layer, the conductive polymer being doped with a polyacid copolymer, the polyacid copolymer being represented by the following Chemical Formula 1:
• UREA DERIVATIVES USEFUL AS KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：US20160318958A1

  公开（公告）日：2016-11-03

  There are provided compounds of formula I, wherein R 1 , R 1A , R 1C to R 1E , R a , R b , X 1 , E and G have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
• US6784183B2
  申请人：——

  公开号：US6784183B2

  公开（公告）日：2004-08-31