ethyl (3E,5E)-3,5-bis[(3-aminophenyl)methylidene]-4-oxopiperidine-1-carboxylate | 1228557-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: ethyl (3E,5E)-3,5-bis[(3-aminophenyl)methylidene]-4-oxopiperidine-1-carboxylate
• CAS: 1228557-73-0
• 化学式: C₂₂H₂₃N₃O₃
• 分子量: 377.443
• InChiKey: VYGQXMPFTMQHID-BEQMOXJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  98.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-溴丙烯酸 、 ethyl (3E,5E)-3,5-bis[(3-aminophenyl)methylidene]-4-oxopiperidine-1-carboxylate 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以46%的产率得到ethyl (3E,5E)-3,5-bis{3-[(2-bromoacryloyl)amino]benzylidene}-4-oxopiperidine-1-carboxylate
  参考文献：
  名称：

  Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

  摘要：

  In a continuing study of hybrid compounds containing the alpha-bromoacryloyl moiety as potential anticancer drugs, we synthesized a novel series of hybrids 4a-h, in which this moiety was linked to a 1,5-diaryl-1,4-pentadien-3-one system. Many of the conjugates prepared (4b, 4c, 4e and 4g) demonstrated pronounced, submicromolar antiproliferative activity against four cancer cell lines. Moreover, compound 4b induced apoptosis through the mitochondrial pathway and activated caspase-3 in a concentration-dependent manner. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.075
• 作为产物：
  描述：

  (3E,5E)-ethyl 3,5-bis(3-nitrobenzylidene)-4-oxopiperidine-1-carboxylate 在 铁粉 、 氯化铵 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 ethyl (3E,5E)-3,5-bis[(3-aminophenyl)methylidene]-4-oxopiperidine-1-carboxylate
  参考文献：
  名称：

  Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation

  摘要：

  In a continuing study of hybrid compounds containing the alpha-bromoacryloyl moiety as potential anticancer drugs, we synthesized a novel series of hybrids 4a-h, in which this moiety was linked to a 1,5-diaryl-1,4-pentadien-3-one system. Many of the conjugates prepared (4b, 4c, 4e and 4g) demonstrated pronounced, submicromolar antiproliferative activity against four cancer cell lines. Moreover, compound 4b induced apoptosis through the mitochondrial pathway and activated caspase-3 in a concentration-dependent manner. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.075

文献信息

• Symmetrical α-bromoacryloylamido diaryldienone derivatives as a novel series of antiproliferative agents. Design, synthesis and biological evaluation
  作者：Romeo Romagnoli、Pier Giovanni Baraldi、Olga Cruz-Lopez、Carlota Lopez Cara、Maria Dora Carrion、Jan Balzarini、Ernest Hamel、Giuseppe Basso、Roberta Bortolozzi、Giampietro Viola

  DOI：10.1016/j.bmcl.2010.03.075

  日期：2010.5

  In a continuing study of hybrid compounds containing the alpha-bromoacryloyl moiety as potential anticancer drugs, we synthesized a novel series of hybrids 4a-h, in which this moiety was linked to a 1,5-diaryl-1,4-pentadien-3-one system. Many of the conjugates prepared (4b, 4c, 4e and 4g) demonstrated pronounced, submicromolar antiproliferative activity against four cancer cell lines. Moreover, compound 4b induced apoptosis through the mitochondrial pathway and activated caspase-3 in a concentration-dependent manner. (C) 2010 Elsevier Ltd. All rights reserved.