dimethyl-(4-nitroso-[1]naphthyl)-amine | 104996-53-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: dimethyl-(4-nitroso-[1]naphthyl)-amine
• 英文别名: Dimethyl-(4-nitroso-[1]naphthyl)-amin；N,N-dimethyl-4-nitrosonaphthalen-1-amine
• CAS: 104996-53-4
• 化学式: C₁₂H₁₂N₂O
• 分子量: 200.24
• InChiKey: IXRDLLNYZLGEHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dimethyl-(4-nitroso-[1]naphthyl)-amine 生成 4-nitrosonaphthalen-1-ol 、 二甲胺
  参考文献：
  名称：

  Friedlaender; Welmans, Chemische Berichte, 1888, vol. 21, p. 3125

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基-1-萘胺 在 硫酸 、 sodium nitrite 作用下， 反应 10.0h， 生成 dimethyl-(4-nitroso-[1]naphthyl)-amine
  参考文献：
  名称：

  On the Nitrosation ofN-monosubstituted 1-naphthylamines - formation ofN-monosubstituted 4-nitroso-1-naphthylamine derivatives and benzocondensed indaminium salts

  摘要：

  By nitrosation of the mineralic acid salts of N-monosubstituted 1-naphthylamines (7) N-monosubstituted N'-hydroxy-naphthoquinone diiminium salts (9) are formed. These compounds can condense with their naphthylamine educts 7 to deeply colored N-(4-amino-naphthyl)-substituted naphthoquinone diiminium salts 11 which are available by the reaction of the mineralic acid salts of N-monosubstituted 1-naphthylamines 7 with one half equivalent of nitrous acid in acetic acid solution also. The new indaminium salts 11 absorb, in contrast to their deprotonated species 12 which exhibit intense absorption bands at about 550 nm, in the near infrared region very intensively at about 820 nm.

  DOI：

  10.1002/prac.19963380181

文献信息

• Near-infrared absorbing methine dyes based on dicyanovinyl derivatives of indane-1,3-dione
  作者：Kasali A. Bello、Lubai Cheng、John Griffiths

  DOI：10.1039/p29870000815

  日期：——

  The synthesis, colour, and constitution of methine dyes formed by condensation of benzaldehydes and nitrosobenzenes with dicyanovinyl analogues of indane-1,3-dione have been investigated. 3-Dicyanovinylindan-1-one (3) and 1,3-bisdicyanovinylindane (5) give magenta (λmax.ca. 560 nm) and blue (λmax.ca. 600 nm) dyes respectively with 4-dialkylaminobenzaldehydes. Aza analogues formed from (3) and (5) and

  研究了苯甲醛和亚硝基苯与茚满-1,3-二酮的二氰基乙烯基类似物缩合形成的次甲基染料的合成，颜色和结构。3- Dicyanovinylindan -1-酮（3）和1,3- bisdicyanovinylindane（5）给出品红（λ最大CA 560纳米）和蓝色（λ最大CA 600纳米）与4- dialkylaminobenzaldehydes分别染料。由（3）和（5）以及4-二烷基氨基亚硝基苯形成的Aza类似物的显色性更高，并且对于由（5）（ca。150 nm）允许合成一类新的在近红外区域吸收的染料，吸收最大值在700–850 nm范围内。
• Verfahren und Sensorelektrodensystem zur elektrochemischen Bestimmung eines Analyts oder einer Oxidoreduktase sowie geeigneter Verbindungen
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0441222A2

  公开（公告）日：1991-08-14

  Gegenstand der Erfindung ist ein Verfahren zur elektrochemischen Bestimmung eines Analyts in Gegenwart einer Oxidoreduktase und einer reduzierbaren Substanz, welche im Verlauf der Bestimmungsreaktion anfallende Elektronen von der Oxidoreduktase auf eine Elektrode überträgt und so zu einem Signal führt, das ein Maß für den zu bestimmenden Analyt ist, wobei die reduzierbare Substanz enzymatisch reduziert und an der Elektrode oxidiert wird, dadurch gekennzeichnet, daß die an der Elektrode durch Oxidation entstehende Substanz von der ursprünglich eingesetzten reduzierbaren Substanz verschieden ist, sowie ein entsprechendes Sensorelektrodensystem und die Verwendung hierfür geeigneter Verbindungen. Schließlich sind auch Gegenstand der Erfindung neue Nitrosoanilinderivate und ein Verfahren zu deren Herstellung.

  本发明的主题是一种在氧化还原酶和还原性物质存在下对被分析物进行电化学测定的方法，该方法将测定反应过程中产生的电子从氧化还原酶转移到电极上，从而产生一个信号，该信号是待测定的被分析物的量度、其中可还原物质在电极上被酶还原和氧化，其特点是在电极上通过氧化形成的物质不同于最初使用的可还原物质，以及相应的传感器电极系统和适用于该系统的化合物的使用。最后，本发明还涉及新的亚硝基苯胺衍生物及其制备工艺。
• Systems and methods for multiple analyte analysis
  申请人：Roche Diabetes Care, Inc.

  公开号：US10466196B2

  公开（公告）日：2019-11-05

  Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.

  本文提供了用于多分析物分析的系统和方法。在一个实施方案中，方法包括确定样品中第一和第二分析物的浓度。例如，第一和第二分析物可以是葡萄糖和羟丁酸。在这种形式中，在确定羟丁酸的浓度高于预定值时，提供与测得的羟丁酸浓度有关的指示。在这种形式的另一个方面，无论测量的葡萄糖浓度值如何，都会自动提供代表测量的葡萄糖浓度的定量指示。在另一个实施例中，系统包括一个仪表，配置为与测试元件交互，以评估样品中的第一和第二分析物。更多的实施方案、形式、目的、特征、优点、方面和益处应从描述和附图中显而易见。
• Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same
  申请人：Roche Diabetes Care, Inc.

  公开号：US11230727B2

  公开（公告）日：2022-01-25

  Detection reagents, multi-analyte test elements, test systems, and multi-analyte measuring methods are provided. In particular, multi-analyte test elements have (1) a first working electrode and first counter electrode pair covered with a first analyte-specific reagent that includes an enzyme, a coenzyme and a first mediator and have (2) a second working electrode covered with a second analyte-specific reagent that includes an enzyme, a coenzyme and a second mediator, where the second mediator is different than the first mediator. The single counter electrode can be used as the counter electrode for both the first and second analyte measurements at their respective working electrodes. Moreover, the mediator concentrations, measurement ranges, and applied potential differences are not the same for each analyte-specific measurement.

  提供了检测试剂、多分析物测试元件、测试系统和多分析物测量方法。特别是，多分析物测试元件具有（1）覆盖有第一分析物特异性试剂（包括酶、辅酶和第一介质）的第一工作电极和第一对反电极，以及（2）覆盖有第二分析物特异性试剂（包括酶、辅酶和第二介质）的第二工作电极，其中第二介质不同于第一介质。单个对电极可用作在各自工作电极上测量第一和第二分析物的对电极。此外，每种特定分析物测量的介质浓度、测量范围和应用电位差都不相同。
• Test strip with flared sample receiving chamber
  申请人：Bhullar S. Raghbir

  公开号：US20050019212A1

  公开（公告）日：2005-01-27

  A test strip with a sample receiving chamber having a novel flared portion that terminates in a sample receiving opening. The flared portion provides a reservoir from which sample fluid can be drawn into the capillary or sample receiving chamber. The wider opening provided by the present invention is easier to “target” with a sample fluid. In preferred embodiments, the hydrophilic reagent layer extends to the dosing end or side of the test strip and further promotes wicking of the sample into the sample receiving chamber and thus reduces dose hesitation. In other preferred embodiments, a tapered dosing end is provided on the test strip in combination with the flared portion, and this combination create a test strip that will draw sample fluid into the sample receiving chamber regardless of where along the dosing edge of the test strip the fluid sample makes contact.

  一种带有样品接收室的试纸，其样品接收室有一个新颖的喇叭形部分，该部分的末端是一个样品接收口。喇叭形部分提供了一个储液器，可将样品流体吸入毛细管或样品接收室。本发明提供的较宽开口更容易 "瞄准 "样品流体。在优选的实施方案中，亲水试剂层延伸到试纸的定量端或侧面，进一步促进样品吸入样品接收室，从而减少定量犹豫。在其他优选的实施方案中，试纸上的锥形定量端与喇叭形部分结合在一起，这种组合产生了一种试纸，无论流体样品沿试纸的定量边缘接触何处，都能将样品流体吸入样品接收腔。