3-methylbutan-2-yl chloroformate | 20412-37-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 3-methylbutan-2-yl chloroformate
• 英文别名: 2-chlorocarbonyloxy-3-methyl-butane；carbonochloridic acid 1,2-dimethyl-propyl ester；chlorocarbonic acid-(1,2-dimethyl-propyl ester)；Chlorameisensaeure-(methylisopropylcarbin)-ester；Chlorokohlensaeure-(1,2-dimethyl-propylester)；1R,2-DimethylPropyl Chloroformate；3-methylbutan-2-yl carbonochloridate
• CAS: 20412-37-7
• 化学式: C₆H₁₁ClO₂
• 分子量: 150.605
• InChiKey: DCKWWQRLTVEAPW-UHFFFAOYSA-N

物化性质

• 沸点：
  151.6±9.0 °C(Predicted)
• 密度：
  1.051±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-benzyl-2-(4-methoxyphenyl)oxazol-5(4H)-one 、 3-methylbutan-2-yl chloroformate 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以96%的产率得到4-benzyl-2-(4-methoxyphenyl)oxazol-5-yl 3-methylbutan-2-yl carbonate
  参考文献：
  名称：

  Probing the Efficiency of N-Heterocyclic Carbene Promoted O- to C-Carboxyl Transfer of Oxazolyl Carbonates

  摘要：

  Screening of a range of azolium salts, bases and solvents for reactivity indicates that triazolinylidenes, generated in situ with KHMDS in THF, promote the Steglich rearrangement of oxazolyl carbonates with high catalytic efficiency (typical reaction time 5 min at < 1.5 mol % NHC). This protocol shows wide substrate applicability, even allowing the efficient generation of vicinal quaternary centers. An improved experimental procedure is also described that allows a simplified one-pot reaction protocol to be employed with similarly high catalytic efficiency.

  DOI：

  10.1021/jo702720a
• 作为产物：
  描述：

  3-甲基-2-丁醇 、 三光气 在 吡啶 作用下， 以 乙醚 为溶剂， 反应 12.0h， 生成 3-methylbutan-2-yl chloroformate
  参考文献：
  名称：

  Design, synthesis and cytotoxicity of novel 3′-N-alkoxycarbonyl docetaxel analogs

  摘要：

  By-product 9a exhibited potent cytotoxicity against both SK-OV-3 and A549 cell lines. The structure of 9a was characterized using 1D and 2D NMR experiments and confirmed by synthesis to afford a diastereomeric mixture (16a) that was identical to 9a, as well as a pair of diastereomers (R)-16b and (S)-16c. The preliminary SAR study demonstrated that analogs with an (R)-configuration were slightly more potent than analogs with an (S)-configuration. In addition, alpha, alpha-gem-dimethyl analogs 16g-i were the most potent analogs in this series, exhibiting similar potency to docetaxel and greater potency than Taxol against the SK-OV-3 cell line. For the A549 cell line, analogs 16g-i were more potent (>65-fold) than both docetaxel and Taxol. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.10.007

文献信息

• Novel peptides as NS3-serine protease inhibitors of hepatitis C virus
  申请人：——

  公开号：US20030216325A1

  公开（公告）日：2003-11-20

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

  本发明公开了具有HCV蛋白酶抑制活性的新化合物，以及制备这种化合物的方法。在另一实施例中，本发明公开了包含这种化合物的药物组合物，以及使用它们治疗与HCV蛋白酶相关的疾病的方法。
• Compounds and methods for treating dyslipidemia
  申请人：Eli Lilly and Company

  公开号：EP2479175A1

  公开（公告）日：2012-07-25

  Compounds of Formula (I): wherein n, m, p, q, Y, R1, R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed.

  式（I）化合物：其中 n、m、p、q、Y、R1、R2、R3a、R3b、R4、R5 和 R6 如本文所定义，并公开了它们的药物组合物和使用方法。
• OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF
  申请人：Kyowa Kirin Co., Ltd.

  公开号：EP3617314A1

  公开（公告）日：2020-03-04

  The present invention provides, for example, an oligonucleotide derivative or a salt thereof comprising a circular oligonucleotide and a linear oligonucleotide, wherein the circular oligonucleotide and the linear oligonucleotide have base sequences complementary to each other, and form a complex via a hydrogen bond between the complementary base sequences, and a method for producing the same.

  例如，本发明提供了一种寡核苷酸衍生物或其盐，包括环状寡核苷酸和线性寡核苷酸，其中环状寡核苷酸和线性寡核苷酸的碱基序列互补，并通过互补碱基序列之间的氢键形成复合物，以及生产这种衍生物的方法。
• METHOD FOR PRODUCING PEPTIDE COMPOUND
  申请人：Nissan Chemical Corporation

  公开号：EP3939959A1

  公开（公告）日：2022-01-19

  The present invention is to provide a method for producing a peptide containing an N-alkylamino acid, which comprises the following Steps (1) to (3). Step (1): a step of mixing an N-terminal protected amino acid or an N-terminal protected peptide with a carboxylic acid halide or a halogenated alkyl formate; Step (2): a step of mixing an amino acid or a peptide in which the N-terminal and the C-terminal are not protected with a trialkylsilylating agent; and Step (3): a step of mixing the product obtained in Step (1) with the product obtained in Step (2).

  本发明旨在提供一种生产含有N-烷基氨基酸的多肽的方法，该方法包括以下步骤(1)至(3)。步骤(1)：将 N 端受保护的氨基酸或 N 端受保护的肽与羧酸卤化物或卤代烷基甲酸酯混合的步骤； 步骤(2)：将 N 端和 C 端未受保护的氨基酸或肽与三烷基硅烷化剂混合的步骤；以及 步骤(3)：将步骤(1)中得到的产物与步骤(2)中得到的产物混合的步骤。
• DE2246282
  申请人：——

  公开号：——

  公开（公告）日：——