3-chlorocarbonyloxy-octane | 56888-14-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 3-chlorocarbonyloxy-octane
• 英文别名: ethylhexyl chloroformate；octan-3-yl carbonochloridate
• CAS: 56888-14-3
• 化学式: C₉H₁₇ClO₂
• 分子量: 192.686
• InChiKey: MBPFTJUGLPIHAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-chlorocarbonyloxy-octane 、 苯基氯化镁 在 吡啶 、 盐酸 、 CuI 、 硫酸 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 以83.5%的产率得到1-(2-ethylhexyloxycarbonyl)-4-phenyl-1,4-dihydropyridine
  参考文献：
  名称：

  Method for producing pyridine compounds

  摘要：

  一种生产化合物（II）的吡啶化合物的方法，包括在存在（i）至少一种酸和至少一种亚硝酸或亚硝酸盐，或（ii）至少一种碱以及过氧化氢溶液的情况下氧化化合物（I）的二氢吡啶化合物：其中在式（I）和（II）中，R1至R5代表氢原子或取代基；L代表烷基、烷氧基、芳基或芳氧基。

  公开号：

  US20020065420A1

文献信息

• [EN] A METHOD OF PREPARING 2-ETHOXY-1-((2'-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)BIPHENYL- 4-YL)METHYL)-1H-BENZO[D]IMIDAZOLE-7-CARBOXYLATES AND CONVERSION THEREOF TO AZILSARTAN<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 2-ÉTHOXY-1-((2'-(5-OXO-4,5-DIHYDRO-1,2,4-OXADIAZOL-3-YL)BIPHÉNYL- 4-YL)MÉTHYL)-1H-BENZO[D]IMIDAZOLE-7-CARBOXYLATES ET LEUR CONVERSION EN AZILSARTAN
  申请人：ZENTIVA KS

  公开号：WO2012139536A1

  公开（公告）日：2012-10-18

  A method of preparing alkyl 2-ethoxy-1-((2'-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3- yl)biphenyl-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylates of the general formula I, wherein R is either a branched or unbranched C1-C4 alkyl, ArCH2, Ar2CH, or Ar3C, wherein Ar is a substituted or unsubstituted phenyl, in which an alkyl 2-ethoxy-1 -((2'- ((hydroxyamino)iminomethyl)biphenyl-4-yl)methyl)- 1H-benzo[d]imidazole-7-carboxylate of the general formula V is reacted with a cyclization agent in a solvent in the presence of suitable bases. (I) (V)

  将通用公式I中的烷基2-乙氧基-1-((2'-(5-氧代-4,5-二氢-1,2,4-噁二唑-3-基)联苯-4-基)甲基)-1H-苯并[d]咪唑-7-羧酸酯制备方法，其中R为支链或直链C1-C4烷基，ArCH2，Ar2CH或Ar3C，其中Ar为取代或未取代苯基，在溶剂中在适当碱的存在下，将通用公式V中的烷基2-乙氧基-1-((2'-((羟胺基)亚胺基)联苯-4-基)甲基)-1H-苯并[d]咪唑-7-羧酸酯与缩合剂反应。
• Heterocyclic compounds with carboxyl isostere groups and their use for the treatment of cardiovascular diseases
  申请人：Bartel Stephan

  公开号：US20090227640A1

  公开（公告）日：2009-09-10

  The present application relates to novel heterocyclic compounds, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.

  本申请涉及新颖的杂环化合物，它们的制备方法，它们用于治疗和/或预防疾病的用途，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。
• ONLINE CONTINUOUS FLOW PROCESS FOR THE SYNTHESIS OF ORGANIC PEROXIDES USING HYDROGEN PEROXIDE AS RAW MATERIAL
  申请人：Shanghai Hybrid-chem Technologies

  公开号：US20200172478A1

  公开（公告）日：2020-06-04

  An online continuous flow production process for directly preparing organic peroxides by using hydrogen peroxide as a raw material. This production process uses hydrogen peroxide, catalyst, and an oxidation substrate as a raw material. Substrate will be turned to designated peroxides sequentially through oxidation and workup. This process is performed in a plug-and-produce integrated continuous flow reactor, and the raw materials are continuously fed to the reactor. So, specified peroxide can be continuously obtained at the outlet of the plug-and-produce integrated continuous flow reactor.

  一种在线连续流程生产方法，通过使用过氧化氢作为原料直接制备有机过氧化物。该生产过程使用过氧化氢、催化剂和氧化底物作为原料。底物将通过氧化和处理逐步转化为指定的过氧化物。该过程在一个即插即用的集成连续流反应器中进行，并且原料持续供给到反应器中。因此，指定的过氧化物可以在即插即用的集成连续流反应器出口处连续获得。
• Single-functional and mixtures of multifunctional oligomeric performance additive compositions, and their use
  申请人：ELF ATOCHEM NORTH AMERICA, INC.

  公开号：EP0332761A2

  公开（公告）日：1989-09-20

  The present invention comprises novel single-functional and mixtures of multi-functional oligomeric performance additive compounds having one or more components of Structure A (The definitions of R, Z1, Z2, Z3, A1, A2, A3 and y are given in the Summary Section), their uses and polymeric compounds and compositions containing them which have enhanced oxidative stabilities, enhanced ultraviolet (UV) and light stabilities and/or enhanced flame retardance. An example is the bis sulfonic acid bispotassium salt reaction product from an oligomeric caprolactone diol (TONE® 260), 2-sulfobenzoic acid anhydride and potassium carbonate, and use of this product, at levels up to about 3.0%, in a general purpose bisphenol A polycarbonate resin, to enhance the fire resistance or flame retardance of the polycarbonate resin.

  本发明包括具有一种或多种结构 A 组分的新型单官能团和多官能团低聚物性能添加剂混合物 （R、Z1、Z2、Z3、A1、A2、A3 和 y 的定义见摘要部分）、它们的用途以及含有它们的聚合物化合物和组合物。 (R、Z1、Z2、Z3、A1、A2、A3 和 y 的定义见摘要部分）、它们的用途以及含有它们的聚合物化合物和组合物，它们具有增强的氧化稳定性、增强的紫外线（UV）和光稳定性和/或增强的阻燃性。例如，低聚己内酯二醇（TONE® 260）、2-磺酸基苯甲酸酐和碳酸钾的双磺酸双钾盐反应产物，以及在通用双酚 A 型聚碳酸酯树脂中使用该产物（含量最高约为 3.0%），可增强聚碳酸酯树脂的耐火性或阻燃性。
• ONLINE FULL CONTINUOUS FLOW PRODUCTION PROCESS FOR DIRECTLY PREPARING ORGANIC PEROXIDE WITH HYDROGEN PEROXIDE AS RAW MATERIAL
  申请人：Shanghai Hybrid-Chem Technologies

  公开号：EP3666755A1

  公开（公告）日：2020-06-17

  An online continuous flow production process for directly preparing organic peroxides by using hydrogen peroxide as a raw material. This production process uses hydrogen peroxide, catalyst, and an oxidation substrate as a raw material. Substrate will be turned to designated peroxides sequentially through oxidation and workup. This process is performed in a plug-and-produce integrated continuous flow reactor, and the raw materials are continuously fed to the reactor. So, specified peroxide can be continuously obtained at the outlet of the plug-and-produce integrated continuous flow reactor.

  一种以过氧化氢为原料直接制备有机过氧化物的在线连续流生产工艺。该生产工艺使用过氧化氢、催化剂和氧化底物作为原料。底物将依次通过氧化和处理变成指定的过氧化物。该工艺在一个即插即用的集成式连续流反应器中进行，原料连续不断地进入反应器。因此，可以在塞-产一体化连续流反应器的出口处连续获得指定的过氧化物。