diisopropylsilanediol | 18173-88-1

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: diisopropylsilanediol
• 英文别名: Diisopropyl-silandiol；dihydroxy-di(propan-2-yl)silane
• CAS: 18173-88-1
• 化学式: C₆H₁₆O₂Si
• 分子量: 148.277
• InChiKey: ZXWUGCNBZZSJJN-UHFFFAOYSA-N

物化性质

• 熔点：
  114 °C(Solv: water (7732-18-5))
• 沸点：
  197.7±23.0 °C(Predicted)
• 密度：
  0.932±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.23
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  diisopropylsilanediol 在 氢氧化钾 、 正丁基锂 作用下， 以 正己烷 为溶剂， 反应 3.0h， 生成 2,2,4,4,6,6-hexaisopropylcyclotrisiloxane
  参考文献：
  名称：

  Graalmann, Onno; Klingebiel, Uwe; Clegg, William, Chemische Berichte, 1984, vol. 117, # 9, p. 2988 - 2997

  摘要：

  DOI：
• 作为产物：
  描述：

  (i-pr)2Si(Oet)2 在 1,4-二氧六环 、 氢氧化钾 、 乙醇 、 氢氟酸 作用下， 生成 diisopropylsilanediol
  参考文献：
  名称：

  Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study

  摘要：

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.

  DOI：

  10.1038/modpathol.3880230

文献信息

• Oxidation of Triorganosilanes and Related Compounds by Chlorine Dioxide
  作者：S. A. Grabovskiy、N. N. Kabal’nova

  DOI：10.1134/s1070363221120069

  日期：2021.12

  mechanism explaining the formation of products and the observed regularities of the oxidation of silanes with chlorine dioxide has been proposed. A thermochemical analysis of some possible pathways in the gas phase using methods G4, G3, M05, and in an acetonitrile solution by the SMD-M05 method was carried out. The oxidation process can occur both with the participation of ionic and radical intermediates

  用二氧化氯氧化三乙基硅烷、叔丁基二甲基硅烷、二甲基苯基硅烷、三苯基硅烷、1,1,1,2四甲基-2-苯基二硅烷、三(三甲基甲硅烷基)硅烷、六甲基二硅烷、四(三甲基甲硅烷基)硅烷、1,1,3,3四异丙基二硅氧烷出去。研究的三有机硅烷与二氧化氯在乙腈溶液中的反应产物是相应的硅烷醇和硅氧烷。已经提出了解释产物形成和观察到的用二氧化氯氧化硅烷的规律的机制。使用方法 G4、G3、M05 对气相中的一些可能途径进行了热化学分析，并通过 SMD-M05 方法对乙腈溶液中的一些可能途径进行了热化学分析。氧化过程可以在离子和自由基中间体的参与下发生，
• Silylation of Alcohols, Phenols, and Silanols with Alkynylsilanes - an Efficient Route to Silyl Ethers and Unsymmetrical Siloxanes
  作者：Krzysztof Kuciński、Hanna Stachowiak、Grzegorz Hreczycho

  DOI：10.1002/ejoc.202000573

  日期：2020.7.15

  Alkynylsilanes – a missing piece of different silylation agents, can serve as valuable substrates in the O‐silylation through a dealkynative coupling with alcohols or silanols. The described approach displays a whole array of advantages in terms of green chemistry and is a promising alternative to existing methodologies.

  炔基硅烷–缺少的一种不同的甲硅烷基化剂，可以通过与醇或硅烷醇的脱炔基偶联而成为O-硅烷化中的重要底物。所描述的方法在绿色化学方面显示了一系列优势，并且是现有方法的有希望的替代方法。
• Ru ⁰ ‐Catalyzed Coupling of Vinylboronates with Silanols, Disilanols, and Disiloxanediols: a Selective Route to Borasiloxanes
  作者：Dawid Frąckowiak、Jędrzej Walkowiak、Grzegorz Hreczycho、Bogdan Marciniec

  DOI：10.1002/ejic.201402212

  日期：2014.7

  A new highly selective method for the synthesis of borasiloxanes through the O-borylation of silanols, disilanols, and disiloxanediols with vinylboronates in the presence of Ru0 complexes (mainly Ru3CO12) is described. The method leads to the formation of special compounds with a B–O–Si inorganic framework. When Ru0 complexes are used as a catalyst, no vinylboronate homocoupling is observed. A mechanism

  描述了在 Ru0 配合物（主要是 Ru3CO12）存在下，通过硅烷醇、二硅烷醇和二硅氧烷二醇与乙烯基硼酸酯的 O-硼酸化来合成硼硅氧烷的一种新的高选择性方法。该方法导致形成具有 B-O-Si 无机骨架的特殊化合物。当使用 Ru0 配合物作为催化剂时，没有观察到乙烯基硼酸酯均偶联。基于 Ru0 与三乙基硅烷醇和乙烯基硼酸酯的化学计量反应，提出了这种转变的机制。
• Chemoselective and Catalyst-Free O-Borylation of Silanols: A Facile Access to Borasiloxanes
  作者：K. Kuciński、G. Hreczycho

  DOI：10.1002/cssc.201701648

  日期：2017.12.8

  highly chemoselective syntheses of various borasiloxanes from hydroboranes and silanols, achieved through catalyst‐free dehydrogenative coupling at room temperature. This green protocol, which uses easily accessible reagents, allows for the obtaining of borasiloxanes under air atmosphere and solvent‐free conditions.

  本文展示了通过氢硼烷和硅烷醇在室温下通过无催化剂的脱氢偶合反应实现的各种硼烷硅氧烷的首次高化学选择性合成。该绿色方案使用易于获得的试剂，可在空气气氛和无溶剂条件下获得硼硅氧烷。
• 直鎖状トリシロキサン化合物の製造方法
  申请人：公益財団法人相模中央化学研究所

  公开号：JP2016150906A

  公开（公告）日：2016-08-22

  【課題】 入手容易な環状トリシロキサンを原料として、分子鎖両末端の一方に水酸基、他方に水酸基又はアルコキシ基を有する直鎖状トリシロキサンを、高収率かつ単工程で製造する方法を提供することを課題とする。【解決手段】水素ガス及び／又は水素発生剤、並びに遷移金属触媒の存在下、種々の環状トリシロキサンを水又はアルコールと反応させることにより、所望のトリシロキサン化合物を製造出来る。【選択図】なし

  The task is to provide a method for producing straight-chain trisiloxane with a hydroxyl group at one end of the molecular chain and a hydroxyl group or alkoxy group at the other end, using an easily accessible cyclic trisiloxane as a raw material, with high yield and in a single step. The solution involves reacting various cyclic trisiloxanes with water or alcohol in the presence of hydrogen gas and/or a hydrogen generator, as well as a transition metal catalyst, to produce the desired trisiloxane compound. No figures are included.