(i-pr)2Si(Oet)2 | 17985-17-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: (i-pr)2Si(Oet)2
• 英文别名: diethoxy-diisopropyl-silane；Diaethoxy-diisopropyl-silan；Diethoxydi(propan-2-yl)silane；diethoxy-di(propan-2-yl)silane
• CAS: 17985-17-0
• 化学式: C₁₀H₂₄O₂Si
• 分子量: 204.385
• InChiKey: VVKJJEAEVBNODX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (i-pr)2Si(Oet)2 在 乙醇 、 氢氟酸 作用下， 生成 difluorodiisopropylsilane
  参考文献：
  名称：

  Malignant Peripheral Nerve Sheath Tumors with t(X;18). A Pathologic and Molecular Genetic Study

  摘要：

  Spindle cell sarcomas often present the surgical pathologist with a considerable diagnostic challenge. Malignant peripheral nerve sheath tumor, leiomyosarcoma, fibrosarcoma, and monophasic synovial sarcoma may all appear similar histologically. The application of ancillary diagnostic modalities, such as immunohistochemistry and electron microscopy, may be helpful in the differentiation of these tumors, but in cases in which these adjunctive: techniques fail to demonstrate any more definitive evidence of differentiation, tumor categorization may remain difficult. Cytogenetic and molecular genetic characterization of tumors have provided the basis for the application of molecular assays as the newest components of the diagnostic armamentarium. Because the chromosomal translocation t(X;18) has been observed repeatedly in many synovial sarcomas, it has been heralded as a diagnostic hallmark of synovial sarcoma To formally test the specificity of this translocation for the diagnosis of synovial sarcoma, RNA extracted from formalin-fixed, parrafin-embedded tissue from a variety of soft tissue and spindle cell tumors was evaluated fbr the presence of t(X;18) by reverse transcriptase-polymerase chain reaction. Although 85% of the synovial sarcomas studied demonstrated t(X;18), 75% of the malignant peripheral nerve sheath tumors in our cohort also demonstrated this translocation. We conclude that the translocation t(X;18) is not specific to synovial sarcoma and discuss the implications of the demonstration of t(X;18) in a majority of malignant peripheral nerve sheath tumors.

  DOI：

  10.1038/modpathol.3880230
• 作为产物：
  描述：

  ((CH₃)₂CH)₂Si(I)₂ 在 C₂H₅OH 、 pyridine 作用下， 以 吡啶 、 乙醇 为溶剂， 生成 (i-pr)2Si(Oet)2
  参考文献：
  名称：

  Eaborn, C., Journal of the Chemical Society

  摘要：

  DOI：

文献信息

• The photolysis of octaisopropylcyclotetrasilane; evidence for the formation of hexaisopropylcyclotrisilane and tetraisopropyldisilene
  作者：Hamao Watanabe、Yuichi Kougo、Yoichiro Nagai

  DOI：10.1039/c39840000066

  日期：——

  Irradiation of octaisopropylcyclotetrasilane (1) in a hydrocarbon solvent successively afforded hexaisopropylcyclotrisilane [Pri2Si]3(2)(λmax320 nm) and tetraisopropyldisilene [Pri2SiSiPri2](3)(λmax 400 nm) with extrusion of di-isopropylsilanediyl (4).

  在烃溶剂中辐照八异丙基环四硅烷（1），依次得到六异丙基环三硅烷[Pr i 2 Si] 3（2）（λmax 320 nm）和四异丙基二ilene [Pr i 2 Si SiPr i 2 ]（3）（λmax 400 nm）。二异丙基硅烷二基（4）的挤出。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Si: MVol.C, 74, page 207 - 208
  作者：

  DOI：——

  日期：——
• Eaborn, Journal of the Chemical Society, 1949, p. 2759
  作者：Eaborn

  DOI：——

  日期：——
• Woronkow et al., 1953, # 12, p. 161,162, 166
  作者：Woronkow et al.

  DOI：——

  日期：——
• A Kinetic View of the Mechanism of the Grignard Reaction with Alkoxysilanes
  作者：Anu Ploom、Ants Tuulmets、Dmitri Panov、Peeter Burk

  DOI：10.1080/10426507.2014.952002

  日期：2015.4.3

  The kinetics of the reaction of n-butyl- and isopropylmagnesium chloride with alkyltriethoxysilanes (RSi(OEt)(3)) in diethyl ether were determined. The rate constants correlate well with the steric parameters E-s(Si). The resulting steric factors delta fit the range of available susceptibility values for the reactions of organosilicon compounds. The thermodynamic activation parameters for six reactions of ethoxysilanes with alkylmagnesium chlorides in dibutyl ether were determined. The entropy values indicated that two Grignard molecules are involved in the transition state of the reaction. From the correlation analysis of the activation enthalpies for the reactions, it appeared that the inductive effect controls the rate of replacement more considerably than steric requirements in the transition state.