5-氯-1,2,4-三唑并[4,3-a]吡啶-3-胺 | 66999-63-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 中文名称: 5-氯-1,2,4-三唑并[4,3-a]吡啶-3-胺
• 英文名称: 3-Amino-5-chloro-s-triazolo<4.3-a>pyridin
• 英文别名: 5-chloro-[1,2,4]triazolo[4,3-a]pyridin-3-ylamine；5-Chloro-[1,2,4]triazolo[4,3-a]pyridin-3-amine
• CAS: 66999-63-1
• 化学式: C₆H₅ClN₄
• mdl: MFCD20705836
• 分子量: 168.585
• InChiKey: IHZHBWVYQLECGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-氯-1,2,4-三唑并[4,3-a]吡啶-3-胺 、 2-溴甲基丙二酸二乙酯 以60%的产率得到
  参考文献：
  名称：

  SCHNELLER S. W.; BARTHOLOMEW D. G., J. HETEROCYCL. CHEM., 1978, 15, NO 3, 439-444

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二氯吡啶 在 一水合肼 作用下， 以 乙醇 、 异丙醇 为溶剂， 反应 5.5h， 生成 5-氯-1,2,4-三唑并[4,3-a]吡啶-3-胺
  参考文献：
  名称：

  [EN] UREA DERIVATIVES AND USES THEREOF
  [FR] DÉRIVÉS DE L'URÉE ET LEURS UTILISATIONS

  摘要：

  公开号：

  WO2014201127A3

文献信息

• Urea derivatives and uses thereof
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US10316022B2

  公开（公告）日：2019-06-11

  The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.

  本发明提供了式(I)-(III)中任一项的新型化合物及其药物组合物。本发明还提供了由式（I）-（III）化合物及其药物组合物组成的具有粘液渗透性的颗粒（如纳米颗粒）。本发明还提供了使用本发明化合物及其药物组合物治疗和/或预防与异常或病理性血管生成和/或生长因子（如血管内皮生长因子（VEGF））异常信号转导有关的疾病的方法和试剂盒，如增殖性疾病（如、如增殖性疾病（如癌症、良性肿瘤、炎症性疾病、自身免疫性疾病）和眼部疾病（如黄斑变性、青光眼、糖尿病视网膜病变、视网膜母细胞瘤、水肿、葡萄膜炎、干眼症、睑缘炎和手术后炎症）。
• UREA DERIVATIVES AND USES THEREOF
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US20150072986A1

  公开（公告）日：2015-03-12

  The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.
• Urea Derivatives and Uses Thereof
  申请人：Kala Pharmaceuticals, Inc.

  公开号：US20190284172A1

  公开（公告）日：2019-09-19

  The present invention provides novel compounds of any one of Formulae (I)-(III), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I)-(III) and pharmaceutical compositions thereof that are mucus penetrating. The invention also provides methods and kits for using the inventive compounds, and pharmaceutical compositions thereof, for treating and/or preventing diseases associated with abnormal or pathological angiogenesis and/or aberrant signaling of a growth factor (e.g., vascular endothelial growth factor (VEGF)), such as proliferative diseases (e.g., cancers, benign neoplasms, inflammatory diseases, autoimmune diseases) and ocular diseases (e.g., macular degeneration, glaucoma, diabetic retinopathy, retinoblastoma, edema, uveitis, dry eye, blepharitis, and post-surgical inflammation) in a subject in need thereof.
• US9212145B2
  申请人：——

  公开号：US9212145B2

  公开（公告）日：2015-12-15
• US9580421B2
  申请人：——

  公开号：US9580421B2

  公开（公告）日：2017-02-28