2-methyl-1-pentyl-piperidine | 108753-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-methyl-1-pentyl-piperidine
• 英文别名: 2-Methyl-1-pentyl-piperidin；Piperidine, 2-methyl-1-pentyl；2-methyl-1-pentylpiperidine
• CAS: 108753-36-2
• 化学式: C₁₁H₂₃N
• 分子量: 169.31
• InChiKey: ZAKOYWKTJPXFDK-UHFFFAOYSA-N

物化性质

• 沸点：
  92-93 °C(Press: 16 Torr)
• 密度：
  0.827±0.06 g/cm3(Predicted)
• 保留指数：
  1190

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-氨基戊烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 1,4-二氧六环 、 copper oxide-chromium oxide 、 氢气 作用下， 250.0 ℃ 、9.81 MPa 条件下， 生成 2-methyl-1-pentyl-piperidine
  参考文献：
  名称：

  Pyrrolidines, Piperidines and Hexahydroazepines from Glycols

  摘要：

  DOI：

  10.1021/ja01272a015

文献信息

• MULTI-RING COMPOUNDS AND USES THEREOF
  申请人：Ohler Norman E.

  公开号：US20100249111A1

  公开（公告）日：2010-09-30

  Chemical agents, such as derivatives of hydroxy benzene moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明涉及化学制剂，例如羟基苯基衍生物及类似的杂环环结构，包括其盐，其作为抗癌和抗肿瘤制剂，特别是这些制剂调节细胞中的酶和结构多肽的活性，例如癌细胞，或这些制剂调节细胞系统中的基因表达水平，包括癌细胞等。本发明还涉及制备这些制剂的方法，以及包含这些制剂作为活性成分的制药组合物和使用这些制剂作为治疗剂的方法。
• Set of Geldanamycin Derivatives and Their Preparation Methods
  申请人：Li Zhuorong

  公开号：US20100311694A1

  公开（公告）日：2010-12-09

  A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90 (Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.

  一组格尔达纳霉素衍生物及其制备方法。包含所述化合物作为活性成分的制药组合物，用作抗病毒和抗肿瘤剂。所述衍生物用于制造抑制热休克蛋白90（Hsp 90）的药剂，具有作为抗病毒和抗肿瘤剂的功效。
• Immunomodulating heterocyclic compounds
  申请人：MediGene Ltd.

  公开号：EP2284172A1

  公开（公告）日：2011-02-16

  A compound of formula (I) or a pharmaceutically or veterinarily acceptable salt, hydrate or solvate thereof: as an inhibitor of CD80 which is useful in immunomodulation therapy.

  式 (I) 的化合物或其药学上或兽医学上可接受的盐、水合物或溶液：作为 CD80 的抑制剂，可用于免疫调节治疗。
• 450. Stereochemical investigations of cyclic bases. Part II. Hofmann degradation of some cyclic quaternary ammonium salts
  作者：K. Jewers、J. McKenna

  DOI：10.1039/jr9580002209

  日期：——
• Hydroxypiperidine Derivatives and Uses Thereof
  申请人：Ohler Norman E.

  公开号：US20090036429A1

  公开（公告）日：2009-02-05

  Chemical agents, such as derivatives of hydroxypiperidine moieties, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of enzymes and structural polypeptides present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.