cyclolignanyingoside A

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基四氢萘木脂素
• 英文名称: cyclolignanyingoside A
• 化学式: C₃₁H₄₂O₁₅
• 分子量: 654.665
• InChiKey: QJSIOFUWCFMPQA-MJJXOWPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.69
• 重原子数：
  46.0
• 可旋转键数：
  11.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  237.45
• 氢给体数：
  9.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  cyclolignanyingoside A 在 盐酸 作用下， 以 氯仿 为溶剂， 反应 4.0h， 生成 可得然胶 、 3-(C-hydroxymethyl)-β-D-erythrofuranose
  参考文献：
  名称：

  A new cyclolignan glycoside from the tubers of Pinellia ternata

  摘要：

  A new 2,7-type cyclolignan glycoside, cyclolignanyingoside A (1), together with six known compounds (2-7) were isolated from the tubers of Pinellia ternata (Thunb.) Breit. The structure of 1 was elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HR-ESI-MS, and CD spectrometry. The cytotoxic, antioxidant and tyrosinase-inhibiting activities of all the isolates were determined. However, all the isolates exhibited no activity on the selected cell lines (Hep-3B, Bcap-37, and MCF-7). In addition, compounds 1-3 and 7 exhibited strong 2,2-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) free radical scavenging activity, and compounds 2 and 4 showed a moderate mushroom tyrsinase inhibitory activity.

  DOI：

  10.1080/10286020.2015.1041931