N-(1-buten-1-yl)piperidine | 7182-10-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-buten-1-yl)piperidine
• 英文别名: 1-but-1-enyl-piperidine；1-but-1-en-ξ-yl-piperidine；1-But-1-en-ξ-yl-piperidin；1-but-1-enylpiperidine
• CAS: 7182-10-7
• 化学式: C₉H₁₇N
• 分子量: 139.241
• InChiKey: YBTBLUIZFVXVOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(1-buten-1-yl)piperidine 在 高氯酸 、 三乙胺 作用下， 生成 4-(5-Ethyl-pyridin-2-yl)-benzonitrile
  参考文献：
  名称：

  Grebyonkin, M. F.; Petrov, V. F.; Belyaev, V. V., Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 129, p. 245 - 258

  摘要：

  DOI：
• 作为产物：
  描述：

  哌啶 、 正丁醛 在 potassium carbonate 作用下， 以55%的产率得到N-(1-buten-1-yl)piperidine
  参考文献：
  名称：

  Enamines from iodine oxidation of trialkylamines. 1. Electrophilic capture by cationic heterocyclic rings

  摘要：

  DOI：

  10.1021/jo00189a004

文献信息

• Sulfenylation of Active Methylene Compounds with Sulfenamides
  作者：Takanobu Kumamoto、Susumu Kobayashi、Teruaki Mukaiyama

  DOI：10.1246/bcsj.45.866

  日期：1972.3

  secondary alkylamines with active methylene compounds afforded mono-sulfenylated compounds in good yields. The reactions of 2 mol of sulfenamides derived from imides with 1 mol of active methylene compounds in the presence of a base gave di-sulfenylated compounds. It was found that α-mono-sulfenylated ketones were prepared by the reactions of enamines with sulfenamides derived from imides. α-gem-Di-sulfenylated

  衍生自仲烷基胺的次磺酰胺与活性亚甲基化合物的等摩尔反应以良好的产率提供单次磺酰化的化合物。2 mol 衍生自酰亚胺的次磺酰胺与 1 mol 活性亚甲基化合物在碱存在下反应，得到二亚磺酰化化合物。发现α-单-亚磺酰化酮是通过烯胺与衍生自酰亚胺的次磺酰胺反应制备的。α-gem-Di-sulfenylated 酮是通过 α-mono-sulfenylated 酮与衍生自酰亚胺的亚磺酰胺在碱存在下反应制备的。还研究了N-苯基硫代苯甲脒盐酸盐的制备和反应。
• Inhibitors of aspartyl protease
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：US06319946B1

  公开（公告）日：2001-11-20

  The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.

  本发明涉及一类新型的磺胺类化合物，它们是天冬氨酸蛋白酶抑制剂。在一个实施例中，本发明涉及一类新型的HIV天冬氨酸蛋白酶抑制剂，其具有特定的结构和理化特征。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制HIV-1和HIV-2蛋白酶活性，因此，可以有益地用作抗HIV-1和HIV-2病毒的抗病毒剂。本发明还涉及使用本发明的化合物抑制HIV天冬氨酸蛋白酶活性的方法以及筛选具有抗HIV活性的化合物的方法。
• Chemical Property of 1-Dialkylamino-2-phenylthioethylene
  作者：Toshio Agawa、Minori Ishikawa、Mitsuo Komatsu、Yoshiki Ohshiro

  DOI：10.1246/bcsj.55.1679

  日期：1982.5

  The olefins which are vicinally substituted by amino and phenylthio groups showed the reactivity as an enamine in the reactions with heterocumulenes and in cycloadditions with a 1,3-dipole and a 2-propenimine, giving a pyrazole derivative and a pyridine derivative, respectively.

  邻位被氨基和苯硫基取代的烯烃在反应中表现出烯胺的反应活性，在与杂环丙烯和1,3-偶极子及2-丙烯亚胺的环加成反应中，分别生成了吡唑衍生物和吡啶衍生物。
• A New Stereoselective Cyclopropane Synthesis
  作者：András Dancsó、Mária Kajtár-Peredy、Csaba Szántay、György Kalaus

  DOI：10.1055/s-1985-31443

  日期：——

  2-Alkyl-2-formyl-cyclopropane-1-carbonitriles 4, 5 and 4-formyl-2-haloalkanenitriles 3 were prepared from aliphatic enamines 1 and 2-haloacrylonitriles 2. Both stereoisomers of the cyclopropane derivatives were obtained stereoselectively using appropriate reaction conditions.

  由脂肪族烯胺1和2-卤代丙烯腈2制备2-烷基-2-甲酰基-环丙烷-1-甲腈4、5和4-甲酰基-2-卤代烷腈3。使用适当的反应条件立体选择性地获得环丙烷衍生物的两种立体异构体。
• 1,3-Dipolar Cycloaddition Reaction of Vinyl Azides with Enamines. Synthesis of Vinyltriazolines and Vinyltriazoles
  作者：Yujiro Nomura、Yoshito Takeughi、Shuji Tomoda、Masato M. Ito

  DOI：10.1246/bcsj.54.261

  日期：1981.1

  Reaction of α- and β-azidostyrene with enamines gave vinyltriazolines regioselectively in moderate yields. 1-Pyrrolidinyl enamines reacted with α-azidostyrene more readily than piperidino or morpholino enamines. β-Azidostyrene was as reactive as azidobenzene while α-azidostyrene was much less reactive. Vinyltriazolines formed from enamines of ketones were deaminated to yield the corresponding vinyltriazoles

  α-和β-叠氮苯乙烯与烯胺反应以中等产率区域选择性地得到乙烯基三唑啉。1-吡咯烷基烯胺比哌啶基或吗啉代烯胺更容易与 α-叠氮苯乙烯反应。β-叠氮苯乙烯的反应性与叠氮苯一样，而 α-叠氮苯乙烯的反应性要低得多。由酮的烯胺形成的乙烯基三唑啉脱氨基得到相应的乙烯基三唑。