2-Naphthalinsulfonylisocyanat | 21926-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Naphthalinsulfonylisocyanat
• 英文别名: 2-naphthylsulfonyl isocyanate；2-naphthalenesulfonyl isocyanate；N-(oxomethylidene)naphthalene-2-sulfonamide
• CAS: 21926-42-1
• 化学式: C₁₁H₇NO₃S
• 分子量: 233.247
• InChiKey: NTUWRIDLXDCARF-UHFFFAOYSA-N

物化性质

• 沸点：
  108 °C(Press: 0.0001 Torr)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Naphthalinsulfonylisocyanat 在 水 作用下， 生成 萘-2-磺酰胺
  参考文献：
  名称：

  Tin for organic synthesis. 10. Unconventional regiospecific syntheses of aromatic carbonamides and thiocarbonamides by means of tin-mediated Friedel-Crafts reactions

  摘要：

  Friedel-Crafts reactions of stannylarenes 1 with tosyl isocyanate (TsNCO, 2) give N-tosylcarbonamides 3 via ipso substitution of the stannyl group. Thus, unconventionally substituted aromatic carbonamides can be obtained. The combination of the reaction of 1 and 2 with that of 1 and chlorosulfonyl isocyanate (14) allows one-pot syntheses of N-(arylsulfonyl)-substituted aromatic carbonamides with optional substitution patterns on both aromatic rings. The known ipso-specific substitutions of stannylarenes with 14 are extended to bi- and tricyclic arenes as well as to thiophenes 6 and 22. One stannyl group can serve as a leaving group for two aromatic systems, as shown with diaryldialkyltins 29. Also, stannylalkanes such as 27 react with 14 to afford alkylsulfonyl isocyanates and products of further reactions, such as 28. From the reactions of 1 with ethoxycarbonyl isothiocyanate (32), ortho- and meta-substituted aromatic thiocarbonamides 33 which are potential precursors for further syntheses, are accessible. The scope, limitations, and mechanism of these electrophilic substitutions are outlined.

  DOI：

  10.1021/jo00077a020
• 作为产物：
  描述：

  potassium;chloro(naphthalen-2-ylsulfonyl)azanide 生成 2-Naphthalinsulfonylisocyanat
  参考文献：
  名称：

  BESENYEI, GABOR;NEMETH, SANDOR;SIMANDI, LASZLO I., ANGEW. CHEM., 102,(1990) N0, C. 1168-1169

  摘要：

  DOI：

文献信息

• Imidazolidine derivative and use thereof
  申请人：Suntory Limited

  公开号：US05691335A1

  公开（公告）日：1997-11-25

  The invention relates to an imidazolidine derivative represented by the following general formula (1): ##STR1## wherein A and B mean individually an aromatic hydrocarbon group which may be substituted by 1-3 substituents selected from halogen atoms, C.sub.1-4 alkyl groups, C.sub.1-4 alkoxy groups, C.sub.1-4 alkylenedioxy groups, a phenoxy group, a nitro group, a cyano group, a phenyl group, C.sub.2-5 alkanoylamino groups, a carboxyl group which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyl groups which may be esterified with a C.sub.1-4 alkyl or alkenyl group, carboxyalkyloxy groups which may be esterified with a C.sub.1-4 alkyl or alkenyl group, N-alkylpiperazinylcarbonyl groups, N-alkylpiperazinylcarbonylalkyl groups, N-alkylpiperazinylcarbonylalkyloxy groups, and a morpholinocarbonyl group; X denotes a sulfonyl or carbonyl group; and Y stands for an oxygen or sulfur atom, a chymase inhibitor comprising the same as an active ingredient, and a medicine comprising the same as an active ingredient, typified by a prophylactic and therapeutic agent for a disease of the heart or circulatory system, which is caused by the abnormal acceleration of production of angiotensin II.

  该发明涉及一种由以下一般式（1）表示的咪唑啉衍生物：##STR1##其中A和B分别表示芳香烃基，该基可能被1-3个卤原子、C.sub.1-4烷基、C.sub.1-4烷氧基、C.sub.1-4烷二氧基、苯氧基、硝基、氰基、苯基、C.sub.2-5烷酰氨基、可能与C.sub.1-4烷基或烯基酯化的羧基、可能与C.sub.1-4烷基或烯基酯化的羧基烷基、可能与C.sub.1-4烷基或烯基酯化的羧基烷氧基、N-烷基哌嗪甲酰基、N-烷基哌嗪甲酰基烷基、N-烷基哌嗪甲酰基烷氧基和吗啉甲酰基；X表示磺酰基或羰基；Y代表氧原子或硫原子，包括作为活性成分的Ⅰ型肽酶抑制剂、以及作为活性成分的药物，其为一种心脏或循环系统疾病的预防和治疗剂，该疾病是由于抑制Ⅱ型肽酶的异常加速产生而引起的。
• Phosphonoureide and phosphonothioureide anthelmintics
  申请人：Rohm and Haas Company

  公开号：US04183921A1

  公开（公告）日：1980-01-15

  This invention relates to novel anthelmintic compounds containing an arylene or divalent heterocyclic ring whose free valences are satisfied by (1) a disubstituted phosphoryl ureido or thioureido group and (2) an amino group or a substituted amido or thioamido group, to compositions containing them, and to methods of using them for the treatment of intestinal parasites in mammals and birds.

  这项发明涉及含有芳基或二价杂环环的新型驱虫化合物，其自由价通过（1）二取代磷酰基脲基或硫脲基团和（2）氨基或取代的酰胺或硫酰胺基团来满足，并涉及含有它们的组合物，以及使用它们治疗哺乳动物和鸟类肠道寄生虫的方法。
• Besenyei, Gabor; Nemeth, Sandor; Simandi, Laszlo J., Angewandte Chemie, 1990, vol. 102, # 10, p. 1168 - 1169
  作者：Besenyei, Gabor、Nemeth, Sandor、Simandi, Laszlo J.

  DOI：——

  日期：——
• ——
  作者：YAMADZI TEHJDZO、 ADZUMA SIDZUO、 XIRAMATSU TOSIYUKI、 ITIKAVA YATARO

  DOI：——

  日期：——
• IMIDAZOLIDINE DERIVATIVE AND USE THEREOF
  申请人：SUNTORY LIMITED

  公开号：EP0721944B1

  公开（公告）日：2001-01-17