2-methoxy-[1,3,2]dioxaphosphinane | 31121-06-9

• 分子结构分类: 有机化合物 - 有机磷化合物 - 亚磷酸三烷基酯
• 英文名称: 2-methoxy-[1,3,2]dioxaphosphinane
• 英文别名: phosphoric acid methyl ester-propanediyl ester；2-Methoxy-[1,3,2]dioxaphosphorinan；Phosphorigsaeure-methylester-propandiylester；2-methoxy-1,3-dioxa-2-phospha-cyclohexane；1,3,2-Dioxaphosphorinane, 2-methoxy-；2-methoxy-1,3,2-dioxaphosphinane
• CAS: 31121-06-9
• 化学式: C₄H₉O₃P
• 分子量: 136.087
• InChiKey: WQQAPJITHNMMNQ-UHFFFAOYSA-N

物化性质

• 沸点：
  111.1±7.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxy-[1,3,2]dioxaphosphinane 在 sulfur 作用下， 以 二硫化碳 为溶剂， 生成 2-methoxy-[1,3,2]dioxaphosphinane 2-sulfide
  参考文献：
  名称：

  Magnetic anisotropy of the unshared electron pair of phosphorus and the P-O, P=O, and P=S bonds in 2-methoxy-1,3,2-dioxaphosphorinanes

  摘要：

  DOI：

  10.1007/bf00961923
• 作为产物：
  描述：

  在 吡啶 作用下， 生成 2-methoxy-[1,3,2]dioxaphosphinane
  参考文献：
  名称：

  Effects of molecular structure on basicity. Gas-phase proton affinities of cyclic phosphites

  摘要：

  DOI：

  10.1021/ja00523a006

文献信息

• Synthesis and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. II.
  作者：IWAO MORITA、KATSUTOSHI KUNIMOTO、MASAMI TSUDA、SHIN-ICHI TADA、MASAHIRO KISE、KIYOSHI KIMURA

  DOI：10.1248/cpb.35.4144

  日期：——

  A series of 1, 4-dihydropyridine-5-cyclic phosphonate derivatives, designed as analogues of 1, 4- dihydropyridine-3, 5-dicarboxylate calcium antagonists, was synthesized and examined for antihypertensive activity. Several compounds were proved to have activities superior or comparable to that of nifedipine in lowering blood pressure in normotensive and spontaneously hypertensive rats (SHR). Among these compounds, methyl 2, 6-dimethyl-5- (2-oxo-1, 3, 2-dioxaphosphorinan-2-yl) -4- (2-nitrophenyl) -1, 4-dihydropyridine-3-carboxylate (31, DHP-218) was approximately 7 times more active than nifedipine in SHR and was selected for further development and clinical evaluation. The structure-activity relationships are discussed.

  合成了一系列1,4-二氢吡啶-5-环状磷酸酯衍生物，作为1,4-二氢吡啶-3,5-二羧酸钙拮抗剂的类似物，并对其抗高血压活性进行了检查。几种化合物在降低正常血压和自发性高血压大鼠（SHR）的血压方面被证明具有优于或可比于硝苯地平的活性。在这些化合物中，甲基2,6-二甲基-5-(2-氧-1,3,2-二氧磷烷-2-基)-4-(2-硝基苯基)-1,4-二氢吡啶-3-羧酸酯（31，DHP-218）在SHR中的活性约为硝苯地平的7倍，并被选为进一步开发和临床评估的候选化合物。讨论了结构-活性关系。
• Cyclic Phosphorylation Reaction of Diols with Tri(1-imidazolyl)phosphine
  作者：Takeo Shimidzu、Kazushige Yamana、Naoya Kanda、Susumu Kitagawa

  DOI：10.1246/bcsj.56.3483

  日期：1983.11

  Tri(1-imidazolyl)phosphine (1) gave the cyclic phosphite quantitatively in the reactions with the diols possessing favorably placed hydroxyl groups in which the distance between the two oxygen atoms is 2.7–3.0 A. The both five- and six-membered cyclic phosphites were obtained quantitatively from the reactions of the diols possessing flexible chains with 1. The course of the selective formation of ribonucleoside

  三（1-咪唑基）膦 (1) 在与具有有利位置羟基的二醇反应中定量生成环状亚磷酸酯，其中两个氧原子之间的距离为 2.7-3.0 A。五元环和六元环亚磷酸酯是从具有柔性链的二醇与 1 的反应中定量获得的。 核糖核苷 2',3'-环状 1-咪唑基亚膦酸酯的选择性形成过程被解释为 1 对 2'-或 3' 的较高反应性-羟基比朝向核糖核苷的 5'-羟基。
• Novel inhibitors of chymase
  申请人：Hawkins J. Michael

  公开号：US20050176769A1

  公开（公告）日：2005-08-11

  The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

  本发明涉及一种化合物，其化学式为(I)，以及制备这些化合物的方法、组合物、中间体和衍生物，以及治疗炎症和丝氨酸蛋白酶介导的疾病的方法。
• Structural implications of nuclear magnetic resonance studies on 1-R-1-phospha-2,6-dioxacyclohexanes
  作者：John G. Verkade、Dennis William White、Richard D. Bertrand、Gerald K. McEwen

  DOI：10.1021/ja00727a018

  日期：1970.12
• Bohlen, Rainer; Hacklin, Henrik; Heine, Joachim, Phosphorus and Sulfur and the Related Elements, 1986, vol. 27, p. 321 - 326
  作者：Bohlen, Rainer、Hacklin, Henrik、Heine, Joachim、Offermann, Werner、Roeschenthaler, Gerd-Volker

  DOI：——

  日期：——