2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)piperazine | 253781-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)piperazine
• 英文别名: tert-butyl-dimethyl-(piperazin-2-ylmethoxy)silane
• CAS: 253781-50-9
• 化学式: C₁₁H₂₆N₂OSi
• 分子量: 230.426
• InChiKey: FVVHRAQLIIBTOK-UHFFFAOYSA-N

物化性质

• 沸点：
  271.3±15.0 °C(Predicted)
• 密度：
  0.883±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.57
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  33.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)piperazine 在 4-二甲氨基吡啶 、 potassium carbonate 、 N,N'-二环己基碳二亚胺 、 potassium iodide 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 4.0h， 生成 (2-(((tertbutyldimethylsilyl)oxy)methyl)piperazine-1,4-diyl)bis(propane-3,1-diyl) bis(2,3-bis(benzyloxy)benzoate)
  参考文献：
  名称：

  Piperazine derivatives as iron chelators: a potential application in neurobiology

  摘要：

  Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.

  DOI：

  10.1007/s10534-015-9889-x
• 作为产物：
  描述：

  2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-1,4-bis(phenylmethyl)piperazine 在 氢氧化钯 silica 、 甲醇 、 二氯甲烷 、 ammonium hydroxide 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以yielding the title compound as a clear oil (450 mg, 57%)的产率得到2-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)piperazine
  参考文献：
  名称：

  Antibacterial agents

  摘要：

  本文揭示了在哺乳动物，特别是人类中治疗细菌感染有用的萘、喹啉、喹硫平和萘啶衍生物。

  公开号：

  US20070161627A1

文献信息

• [EN] ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS
  申请人：GLAXO GROUP LTD

  公开号：WO2006020561A3

  公开（公告）日：2006-08-24
• Piperazine derivatives as iron chelators: a potential application in neurobiology
  作者：S. Abdelsayed、N. T. Ha Duong、C. Bureau、P. P. Michel、E. C. Hirsch、J. M. El Hage Chahine、N. Serradji

  DOI：10.1007/s10534-015-9889-x

  日期：2015.12

  Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects.
• Antibacterial agents
  申请人：Miller Henry William

  公开号：US20070161627A1

  公开（公告）日：2007-07-12

  Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

  本文揭示了在哺乳动物，特别是人类中治疗细菌感染有用的萘、喹啉、喹硫平和萘啶衍生物。