1-(2,2-Dimethoxyethoxy)-naphthalin | 170936-31-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2,2-Dimethoxyethoxy)-naphthalin
• 英文别名: 1-(2,2-dimethoxyethoxy)naphthalene
• CAS: 170936-31-9
• 化学式: C₁₄H₁₆O₃
• 分子量: 232.279
• InChiKey: AYMIUAGKJVCALB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2,2-Dimethoxyethoxy)-naphthalin 在 盐酸 作用下， 以 乙腈 为溶剂， 反应 0.33h， 以99%的产率得到2-萘-1-氧基乙醛
  参考文献：
  名称：

  Aminoalkohole, 2. Mitt.: Ein Verfahren zur Herstellung enantiomerenreiner pharmakologisch aktiver ?-Aminoalkohole

  摘要：

  A synthesis of beta-aminoalcohols is described starting from racemic or enantiomerically pure alpha-hydroxynitriles which were O-protected using enantiomerically pure acetal type protective groups. Reduction with lithium aluminium hydride yielded O-protected beta-aminoalcohols. Whenever diastereomeric O-protected cyanohydrins could not be separated, the mixture was reduced and the resulting O-protected aminoalcohols were separated. Removal of the protective group using hydrogen chloride and methanol yielded enantiomerically pure beta-aminoalcohols or their corresponding hydrochlorides.

  DOI：

  10.1007/bf00813211
• 作为产物：
  描述：

  2-氯乙醛缩二甲醇 、 萘酚 在 sodium hydride 作用下， 生成 1-(2,2-Dimethoxyethoxy)-naphthalin
  参考文献：
  名称：

  Aminoalkohole, 2. Mitt.: Ein Verfahren zur Herstellung enantiomerenreiner pharmakologisch aktiver ?-Aminoalkohole

  摘要：

  A synthesis of beta-aminoalcohols is described starting from racemic or enantiomerically pure alpha-hydroxynitriles which were O-protected using enantiomerically pure acetal type protective groups. Reduction with lithium aluminium hydride yielded O-protected beta-aminoalcohols. Whenever diastereomeric O-protected cyanohydrins could not be separated, the mixture was reduced and the resulting O-protected aminoalcohols were separated. Removal of the protective group using hydrogen chloride and methanol yielded enantiomerically pure beta-aminoalcohols or their corresponding hydrochlorides.

  DOI：

  10.1007/bf00813211

文献信息

• ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE RESIN COMPOSITION, AND ACTINIC RAY-SENSITIVE OR RADIATION-SENSITIVE FILM AND PATTERN FORMING METHOD USING THE COMPOSITION
  申请人：INASAKI Takeshi

  公开号：US20130004888A1

  公开（公告）日：2013-01-03

  An object of the present invention is to provide an actinic ray-sensitive or radiation-sensitive resin composition that can form independent line patterns with high resolution and excellent shapes and shows excellent resist performances including roughness characteristics, and to provide an actinic ray-sensitive or radiation-sensitive film and a pattern forming method using the composition. The actinic ray-sensitive or radiation-sensitive resin composition contains a compound (P) that contains at least one phenolic hydroxyl group and at least one group in which a hydrogen atom of a phenolic hydroxyl group is substituted with a group represented by the following General Formula (1) (the respective symbols in the formula represent the same definitions as in the claims and the specification).

  本发明的目的是提供一种光致或辐射致敏树脂组合物，该组合物可以形成具有高分辨率和优秀形状的独立线型图案，并显示出包括粗糙特性在内的优异的抗阻性能，以及提供使用该组合物的光致或辐射致敏膜和图案形成方法。光致或辐射致敏树脂组合物包含一种化合物（P），该化合物含有至少一个酚羟基和至少一个氢原子被代表如下通式（1）的基团取代的酚羟基的基团（式中各符号与权利要求书和说明书中的定义相同）。
• (Dipropylamino)-tetrahydronaphthofurans: centrally acting serotonin agonists and dopamine agonists-antagonists
  作者：Peter Stjernlöf、Chiu-Hong Lin、Clas Sonesson、Kjell Svensson、Martin W. Smith

  DOI：10.1016/s0960-894x(97)10068-3

  日期：1997.11

  CNS-active aminotetralins containing phenolic moieties were transformed in a simple two-step procedure to the corresponding benzofurans. The compounds were tested in in vitro binding studies at serotonin 5-HT1A and 5-HT2 and dopamine D-2, D-3 and D-4 receptors. These studies revealed that the furan homologs showed overall lower affinities than the phenol counterparts. This was also reflected in vivo in biochemical studies. The benzofuran compounds retained most of the agonist/antagonist activities but with lower potency.
• US8574814B2
  申请人：——

  公开号：US8574814B2

  公开（公告）日：2013-11-05
• Aminoalkohole, 2. Mitt.: Ein Verfahren zur Herstellung enantiomerenreiner pharmakologisch aktiver ?-Aminoalkohole
  作者：C. R. Noe、M. Knollm�ller、P. G�rtner、W. Fleischhacker、E. Katikarides

  DOI：10.1007/bf00813211

  日期：1995.4

  A synthesis of beta-aminoalcohols is described starting from racemic or enantiomerically pure alpha-hydroxynitriles which were O-protected using enantiomerically pure acetal type protective groups. Reduction with lithium aluminium hydride yielded O-protected beta-aminoalcohols. Whenever diastereomeric O-protected cyanohydrins could not be separated, the mixture was reduced and the resulting O-protected aminoalcohols were separated. Removal of the protective group using hydrogen chloride and methanol yielded enantiomerically pure beta-aminoalcohols or their corresponding hydrochlorides.