α,α-diphenyl-3,5-dimethoxysalicyl alcohol | 1044217-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: α,α-diphenyl-3,5-dimethoxysalicyl alcohol
• 英文别名: 2-(hydroxydiphenylmethyl)-4,6-dimethoxyphenol；2-[Hydroxy(diphenyl)methyl]-4,6-dimethoxyphenol；2-[hydroxy(diphenyl)methyl]-4,6-dimethoxyphenol
• CAS: 1044217-94-8
• 化学式: C₂₁H₂₀O₄
• 分子量: 336.387
• InChiKey: RBQUPVLPPDQWSP-UHFFFAOYSA-N

物化性质

• 沸点：
  506.1±30.0 °C(Predicted)
• 密度：
  1.215±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  α,α-diphenyl-3,5-dimethoxysalicyl alcohol 在 四磷十氧化物 作用下， 以 甲苯 为溶剂， 反应 22.0h， 以68%的产率得到2,4,8,10-Tetramethoxy-6,6,12,12-tetraphenylbenzo[c][1,5]benzodioxocine
  参考文献：
  名称：

  在不使用任何其他化学试剂的情况下在中性条件下安装光不稳定的羰基保护基团

  摘要：

  描述了在不使用任何其他化学试剂的情况下在中性条件下为羰基化合物安装光不稳定保护基团的方法。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

  DOI：

  10.1002/ejoc.200800966
• 作为产物：
  描述：

  2-Hydroxy-3,5-dimethoxy-benzoesaeure-methylester 、 苯基锂 以 四氢呋喃 为溶剂， 反应 1.5h， 以99%的产率得到α,α-diphenyl-3,5-dimethoxysalicyl alcohol
  参考文献：
  名称：

  顺序除去具有控制波长的羰基光不稳定保护基

  摘要：

  已经开发出一组坚固且易于制造的羰基化合物的光不稳定保护基（PPG）。通过控制照射波长，可以依次去除不同的PPG。

  DOI：

  10.1021/jo8008275

文献信息

• Development of Trityl-Based Photolabile Hydroxyl Protecting Groups
  作者：Lei Zhou、Haishen Yang、Pengfei Wang

  DOI：10.1021/jo200692c

  日期：2011.8.5

  A series of trityl-based photolabile hydroxyl protecting groups have been examined. These PPGs evolve from the traditional acid-labile trityl protecting group with proper electron-donating substituents. Structure-reactivity relationships have been explored. A m-dimethylamino group is crucial to achieve high photochemical deprotection efficiency. The o-hydroxyl group in 8 greatly improves the yield of the photochemical deprotection reaction, compared with the corresponding o-methoxyl-substituted counterpart 7. However, comparison between the photoreactions of 9 and 11 does not show similar structural relevance. The PPG in ether I (i.e., DMATr group) is structurally simple and easy to prepare and install. Its deprotection can be successfully carried out with irradiation of sunlight without requirement of photochemical devices.
• [EN] PHOTO-ACTIVATABLE THERAPEUTIC AGENTS AND METHODS OF USING<br/>[FR] AGENTS THÉRAPEUTIQUES PHOTO-ACTIVABLES ET PROCÉDÉS D'UTILISATION
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2010042600A2

  公开（公告）日：2010-04-15

  Novel photo-activatable pro-therapeutic agents and methods for their synthesis and use are described. The photo-activatable pro-therapeutic agents are inactive pro-forms of compounds that can be activated in situ, for example, by providing a pro-therapeutic agent to a subject and photo-activating the pro-therapeutic agent at a selected area of the subject. Also disclosed are methods for administering the photo-activatable pro-therapeutic agents to a subject then activating the pro-therapeutic agents at a selected area of the subject by exposing that area to light.
• [EN] PHOTO-ACTIVATED PROTECTING GROUPS<br/>[FR] GROUPES PROTECTEURS PHOTO-ACTIVÉS
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2010042596A2

  公开（公告）日：2010-04-15

  Novel photo-activated protecting groups, photo-activatable groups, and methods for their synthesis and use are described. The photo-activated protecting groups are useful in making photo-activatable forms, i.e., inactive proforms, of compounds that can be activated in situ, for example, for initiating chemical reactions upon photo-activation or providing an inactive proform of a therapeutic agent to a subject and photo-activating the therapeutic agent at a selected area of the subject. Also disclosed are methods for administering a photo-activatable compound to a subject then activating the compound at a selected area of the subject by exposing that area to light.
• Sequential Removal of Photolabile Protecting Groups for Carbonyls with Controlled Wavelength
  作者：Pengfei Wang、Yun Wang、Huayou Hu、Cierra Spencer、Xing Liang、Lurong Pan

  DOI：10.1021/jo8008275

  日期：2008.8.1

  A group of robust and easy-to-make photolabile protecting groups (PPGs) for carbonyl compounds has been developed. Sequential removal of different PPGs is achieved via control of irradiation wavelength.

  已经开发出一组坚固且易于制造的羰基化合物的光不稳定保护基（PPG）。通过控制照射波长，可以依次去除不同的PPG。
• Installation of Photolabile Carbonyl-Protecting Groups under Neutral Conditions without Using Any Other Chemical Reagents
  作者：Pengfei Wang、Yun Wang、Huayou Hu、Xing Liang

  DOI：10.1002/ejoc.200800966

  日期：2009.1

  Methods of installing photolabile protecting groups for carbonyl compounds under neutral conditions without using any other chemical reagents are described. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

  描述了在不使用任何其他化学试剂的情况下在中性条件下为羰基化合物安装光不稳定保护基团的方法。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)