(Z)-2,3-bis(4-fluorophenyl)acrylonitrile | 324-59-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (Z)-2,3-bis(4-fluorophenyl)acrylonitrile
• 英文别名: (Z)-2,3-bis(4-fluorophenyl)prop-2-enenitrile
• CAS: 324-59-4
• 化学式: C₁₅H₉F₂N
• 分子量: 241.24
• InChiKey: VKJZEHJWDFHDKM-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (Z)-2,3-bis(4-fluorophenyl)acrylonitrile 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 2.5h， 以91%的产率得到2,3-bis(4-fluorophenyl)propanenitrile
  参考文献：
  名称：

  Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells

  摘要：

  DOI：

  10.1007/s10571-021-01072-9
• 作为产物：
  描述：

  对氟苯乙腈 、 对氟苯甲醛 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 3.0h， 以97%的产率得到(Z)-2,3-bis(4-fluorophenyl)acrylonitrile
  参考文献：
  名称：

  Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells

  摘要：

  DOI：

  10.1007/s10571-021-01072-9

文献信息

• Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C–CN Bond Cleavage and Cyano Transfer
  作者：Hui Chen、Shuhao Sun、Yahu A. Liu、Xuebin Liao

  DOI：10.1021/acscatal.9b04586

  日期：2020.1.17

  methods to prepare aryl nitriles and vinyl nitriles from aryl halides and alkynes, respectively. Using inexpensive and non-toxic 4-cyanopyridine N-oxide as the cyano shuttle, the methods provide an efficient approach to prepare aryl cyanides and vinyl nitriles under mild and operationally simple reaction conditions with a broad range of functional group tolerance. In hydrocyanation of alkynes, the method

  我们报告镍催化氰化和氢氰化方法分别从芳基卤化物和炔烃制备芳基腈和乙烯基腈。使用廉价且无毒的4-氰基吡啶N-氧化物作为氰基梭，该方法提供了一种在温和且操作简单的反应条件下制备具有宽泛官能团耐受性的芳基氰化物和乙烯基腈的有效方法。在炔烃的氢氰化中，该方法表现出良好的区域选择性，可控方式主要产生E或Z烯基腈，而分别以内部二芳基炔烃和末端炔烃为底物时，则仅产生马尔可夫尼科夫乙烯基腈。
• Nucleophilic Cyanation of Enones and Imines with Formamide as the Cyano Source
  作者：Lei Luo、Hong Dai、Ming‐Qing Yang、Luo Yang

  DOI：10.1002/adsc.202400482

  日期：——

  Conflict of Interests The authors declare no competing financial interest.

  利益冲突 作者声明不存在竞争性经济利益。
• Synthesis and photophysical properties of new reactive fluorophenanthrenes
  作者：Amira K. Hajri、Marzough A. Albalawi、Nadia H. Elsayed、Faouzi Aloui

  DOI：10.5802/crchim.29

  日期：——

  A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions. The target phenanthrenes were characterized by H-1 and C-13 NMR and FT-IR spectroscopies. UV-Vis absorption and photoluminescence of these phenanthrenes were evaluated in solutions. A notable behavior and a strong fluorescence in the blue region of the visible spectrum were observed, making them potential candidates for organic light-emitting diode technology or advanced materials. Their electrochemical behavior was also experimentally examined in solution, demonstrating an important charge transfer interaction owing to their pi-conjugated electronic system.
• HUBSCH, WALTER;ANGERBAUER, ROLF;FEY, PETER;BISCHOFF, HILMAR;PETZINNA, DIE+
  作者：HUBSCH, WALTER、ANGERBAUER, ROLF、FEY, PETER、BISCHOFF, HILMAR、PETZINNA, DIE+

  DOI：——

  日期：——