2-((5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)thio)acetic acid | 1365060-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并嘧啶酮衍生物
• 英文名称: 2-((5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)thio)acetic acid
• 英文别名: 2-(5-chloro-6-methylthieno[2,3-d]pyrimidin-4-ylthio)acetic acid；2-(5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetic acid
• CAS: 1365060-89-4
• 化学式: C₉H₇ClN₂O₂S₂
• 分子量: 274.752
• InChiKey: XEVLMTSZUBIPOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  117
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-哌嗪酮 、 2-((5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)thio)acetic acid 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 生成 4-[2-(5-Chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)sulfanylacetyl]piperazin-2-one
  参考文献：
  名称：

  Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

  摘要：

  The carboxylesterase Notum is a key negative regulator of the Wnt signaling pathway by mediating the depalmitoleoylation of Wnt proteins. Our objective was to discover potent small molecule inhibitors of Notum suitable for exploring the regulation of Wnt signaling in the central nervous system. Scaffold-hopping from thienopyrimidine acids 1 and 2, supported by X-ray structure determination, identified 3-methylimidazolin-4-one amides 20-24 as potent inhibitors of Notum with activity across three orthogonal assay formats (biochemical, extra-cellular, occupancy). A preferred example 24 demonstrated good stability in mouse microsomes and plasma, and cell permeability in the MDCK-MDR1 assay albeit with modest P-gp mediated efflux. Pharmacokinetic studies with 24 were performed in vivo in mouse with single oral administration of 24 showing good plasma exposure and reasonable CNS penetration. We propose that 24 is a new chemical tool suitable for cellular studies to explore the fundamental biology of Notum.

  DOI：

  10.1016/j.bmcl.2019.126751
• 作为产物：
  描述：

  6-甲基-3H-噻吩[2,3-D]嘧啶-4-酮 在 N-氯代丁二酰亚胺 、 水 、 溶剂黄146 、 三乙胺 、 sodium hydroxide 、 三氯氧磷 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 14.17h， 生成 2-((5-chloro-6-methylthieno[2,3-d]pyrimidin-4-yl)thio)acetic acid
  参考文献：
  名称：

  INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE

  摘要：

  揭示了用于治疗、管理和预防影响骨骼的疾病和紊乱的化合物。特定的化合物是Notum果胶乙酰酶的强效抑制剂，化学结构如下：其中E、G、Y、Z、R1、R2和R3如本文所定义。

  公开号：

  US20120065200A1

文献信息

• 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE
  申请人：BARBOSA Joseph

  公开号：US20120302562A1

  公开（公告）日：2012-11-29

  Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.

  描述了可以用来抑制Notum果胶乙酰酯酶的化合物，以及包含它们的组合物，以及它们用于治疗影响骨骼的疾病和紊乱的方法。
• Stimulation of cortical bone formation with thienopyrimidine based inhibitors of Notum Pectinacetylesterase
  作者：James E. Tarver、Praveen K. Pabba、Joseph Barbosa、Qiang Han、Michael W. Gardyan、Robert Brommage、Andrea Y. Thompson、James M. Schmidt、Alan G.E. Wilson、Wei He、Victoria K. Lombardo、Kenneth G. Carson

  DOI：10.1016/j.bmcl.2016.02.021

  日期：2016.3

  A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified. (C) 2016 Elsevier Ltd. All rights reserved.
• US20140256784A1
  申请人：——

  公开号：US20140256784A1

  公开（公告）日：2014-09-11
• US9624238B2
  申请人：——

  公开号：US9624238B2

  公开（公告）日：2017-04-18
• [EN] INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE LA NOTUM PECTINE ACÉTYLESTÉRASE ET PROCÉDÉS POUR LEUR UTILISATION
  申请人：LEXICON PHARMACEUTICALS INC

  公开号：WO2012037141A1

  公开（公告）日：2012-03-22

  Compounds are disclosed for the treatment, management and prevention of diseases and disorders affecting the bone. Particular compounds are potent inhibitors of Notum Pectinacetylesterase, and are of the formula: wherein E, G, Y, Z, R1, R2, and R3 are defined herein.