N-(对甲基苯基)戊二酰亚胺 | 81305-69-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: N-(对甲基苯基)戊二酰亚胺
• 英文名称: N-(p-methylphenyl)glutarimide
• 英文别名: N-Tolylpiperidin-2,6-dion；1-(p-tolyl)piperidine-2,6-dione；N-p-tolyl-glutarimide；N-p-Tolyl-glutarimid；N-(P-Tolyl)glutarimide；1-(4-methylphenyl)piperidine-2,6-dione
• CAS: 81305-69-3
• 化学式: C₁₂H₁₃NO₂
• mdl: MFCD00158661
• 分子量: 203.241
• InChiKey: BLZQHEZIKMURQC-UHFFFAOYSA-N

物化性质

• 沸点：
  435.7±24.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(对甲基苯基)戊二酰亚胺 在 3-溴丙烯 作用下， 以 异丙醇 为溶剂， 以80%的产率得到乙烷,三氯氟-
  参考文献：
  名称：

  通过选择性 C-N 键裂解解锁酰胺：烯丙基溴介导的含氮官能团的发散合成

  摘要：

  我们报告了一组新的反应，该反应基于通过用烯丙基溴进行简单处理来解锁酰胺，为获得各种含氮官能团（如伯酰胺、磺胺、伯胺、N-酰基化合物）创造了一个通用平台。酯、硫酯、酰胺）和N-磺酰基酯。该方法具有潜在的工业实用性，如通过克级规模的分批和连续流动系统合成所证明的那样。

  DOI：

  10.1021/acs.orglett.1c03541
• 作为产物：
  描述：

  戊二酸酐 在 sodium acetate 、 乙酸酐 作用下， 以 甲苯 为溶剂， 生成 N-(对甲基苯基)戊二酰亚胺
  参考文献：
  名称：

  通过选择性 C-N 键裂解解锁酰胺：烯丙基溴介导的含氮官能团的发散合成

  摘要：

  我们报告了一组新的反应，该反应基于通过用烯丙基溴进行简单处理来解锁酰胺，为获得各种含氮官能团（如伯酰胺、磺胺、伯胺、N-酰基化合物）创造了一个通用平台。酯、硫酯、酰胺）和N-磺酰基酯。该方法具有潜在的工业实用性，如通过克级规模的分批和连续流动系统合成所证明的那样。

  DOI：

  10.1021/acs.orglett.1c03541

文献信息

• NANOCOMPOSITE AND DISPERSION COMPRISING THE SAME
  申请人：Morishita Takuya

  公开号：US20120053288A1

  公开（公告）日：2012-03-01

  A nanocomposite comprises a nanostructure, and a copolymer adsorbed to the nanostructure and containing at least one ionic monomer unit and a different monomer unit from the ionic monomer unit; the ionic monomer unit selected from the group consisting of a zwitterionic monomer unit and a cationic monomer unit which are represented by the following formula (1): (in the formula (1), R 1 , R 2 , and R 3 each independently represent any one of a hydrogen atom and a monovalent organic group having 1 to 20 carbon atoms, Y 1 represents any one of a carbonyl group and an arylene group, Y 2 represents any one of —O— and —NH—, n is 0 or 1, R 4 represents a divalent organic group having 1 to 20 carbon atoms, and X represents any one of a zwitterionic group and a cationic group).

  一种纳米复合材料包括纳米结构和吸附在纳米结构上的共聚物，该共聚物包含至少一个离子单体单元和一个不同于离子单体单元的单体单元；所述离子单体单元选自以下公式（1）表示的带电单体单元组中的具有两性离子单体单元和阳离子单体单元：（在公式（1）中，R1、R2和R3各自独立地表示氢原子和具有1到20个碳原子的一价有机基团，Y1表示羰基基团和芳基基团中的任意一种，Y2表示-O-和-NH-中的任意一种，n为0或1，R4表示具有1到20个碳原子的二价有机基团，X表示具有两性离子基团和阳离子基团中的任意一种）。
• <i>N</i>-Alkynyl Imides (Ynimides): Synthesis and Use as a Variant of Highly Labile Ethynamine
  作者：Takuya Sueda、Ayumi Oshima、Naoki Teno

  DOI：10.1021/ol2014973

  日期：2011.8.5

  This study describes the first reliable synthesis of N-alkynyl imides (ynimides). This was accomplished with a copper-catalyzed coupling reaction between alkynyl(triaryl)bismuthonium salts and five-membered imides. We also found that it was possible to utilize N-ethynyl phthalimide as a variant of the highly labile ethynamine. 4-Amino-1,2,3-triazole was successfully obtained via the CuAAC reaction of N-ethynyl phthalimide with azide followed by hydrazinolysis of the phthaloyl protecting group.
• Congener derivatives and conjugates of histamine: synthesis and tissue and receptor selectivity of the derivatives
  作者：M. M. Khan、K. L. Melmon、D. Marr-Leisy、M. S. Verlander、M. Egli、S. Lok、M. Goodman

  DOI：10.1021/jm00394a031

  日期：1987.11

  A series of 19 congener derivatives and conjugates of histamine was synthesized and tested to determine whether the ligands would alter the conventional histamine activity in various tissues. The derivatives, which contained either branched or unbranched aliphatic groups, aromatic amide groups, or dipeptides, exhibited affinities for histamine type 1 and/or type 2 receptors that were widely different from the progenitor. The p-trifluoromethyl derivative of histamine with an intermediate chain length of four methylenes (compound 13) was the most potent lymphocytes H2 receptor agonist but was inactive on guinea pig myocardium H2 receptors. The deletion of a single methylene chain (compound 12) from this compound resulted in total loss of its H2 activity on lymphocytes and its H1 activity on aorta. Compound 12 became an exclusive H1 agonist on lymphocytes H1 receptors. The dipeptide conjugate (compound 17) and the aliphatic congener derivative (compound 18), both with four methylenes, retained some of the activity on guinea pig myocardium H2 receptors, but lost their activity on lymphocytes H2 receptors. Therefore, histamine can be modified at sites that are at a distance from the imidazole moiety, resulting in tissue selective histamine receptor agonists.
• Unsaturated Lactams: New Inputs for Povarov-Type Multicomponent Reactions
  作者：Esther Vicente-García、Federica Catti、Rosario Ramón、Rodolfo Lavilla

  DOI：10.1021/ol902913j

  日期：2010.2.19

  Unsaturated lactams with endo- or exocyclic C-C double bonds constitute a set of reactive inputs that serve as the electron-rich olefin component in Povarov reactions. These substrates afford the multicomponent adducts in convenient yields and offer a wide range of structural diversity. Postcondensation transformations allow direct access to a variety of lactam-fused and amide-substituted quinoline derivatives.
• Rajput; Girase, Indian Journal of Heterocyclic Chemistry, 2012, vol. 21, # 3, p. 201 - 208
  作者：Rajput、Girase

  DOI：——

  日期：——