1-甲基哌啶-4-醇盐酸盐 | 80154-05-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 1-甲基哌啶-4-醇盐酸盐
• 英文名称: 1-methylpiperidin-4-ol monohydrochloride
• 英文别名: 1-methyl-piperidin-4-ol; hydrochloride；1-Methyl-piperidin-4-ol; Hydrochlorid；1-Methyl-4-piperidinol hydrochloride；1-methylpiperidin-4-ol;hydrochloride
• CAS: 80154-05-8
• 化学式: C₆H₁₃NO*ClH
• 分子量: 151.636
• InChiKey: IPVYMXZYXFFDGW-UHFFFAOYSA-N

物化性质

• 熔点：
  154 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.49
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-甲基哌啶-4-醇盐酸盐 在 甲醇 、 silver(I) bromide 、 乙醚 作用下， 生成 溴帕拉喷酯
  参考文献：
  名称：

  Parasympathetic Blocking Agents. III. Phenylglycolic Acid Esters of N-Alkyl-4-piperidinol

  摘要：

  DOI：

  10.1021/ja01596a040
• 作为产物：
  描述：

  N-甲基-4-哌啶酮 在 platinum(IV) oxide 氢气 作用下， 以 盐酸 为溶剂， 反应 40.0h， 以330 mg的产率得到N-methyl-piperidine hydrochloride
  参考文献：
  名称：

  Wysocka, Waleria, Bulletin de l'Academie Polonaise des Sciences, Serie des Sciences Chimiques, 1980, vol. 28, # 4, p. 263 - 275

  摘要：

  DOI：

文献信息

• Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 1. Tropic and 2-Phenylpropionic Acid Esters
  作者：Fulvio Gualtieri、Gabriele Conti、Silvia Dei、Maria Paola Giovannoni、Francesca Nannucci、Maria Novella Romanelli、Serena Scapecchi、Elisabetta Teodori、Luisa Fanfani、Carla Ghelardini、Alberto Giotti、Alessandro Bartolini

  DOI：10.1021/jm00037a022

  日期：1994.5

  of obtaining drugs which are able to increase ACh release and consequently to show analgesic and nootropic activities. The results showed that several new compounds are indeed potent analgesics (with an analgesic efficacy comparable to that of morphine) and that the most potent one ((+/-)-19, PG9) also has remarkable cognition-enhancing properties. Our study confirmed that the mechanism of action involves

  先前的研究表明，（R）-（+）-hyscyamine具有镇痛活性，这是由于中央毒蕈碱自体受体拮抗后ACh释放增加所致。由于增强中央胆碱能传递可能对认知障碍有益，因此我们操纵了（R）-（+）-水苏胺，合成了几种热带和2-苯基丙酸衍生物，目的是获得能够增加ACh释放的药物因此具有镇痛和促智作用。结果表明，几种新化合物确实是有效的镇痛药（镇痛作用与吗啡相当），并且最有效的一种（（+/-）-19，PG9）也具有显着的认知增强特性。
• [EN] ALKYNYL SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASES INHIBITORS<br/>[FR] PYRIMIDINYL-PYRROLES SUBSTITUÉS ALCYNYLE AGISSANT COMME INHIBITEURS DE KINASE
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2013014039A1

  公开（公告）日：2013-01-31

  The present invention relates to alkynyl substituted pyrimidinyl-pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak and/or Src family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

  本发明涉及烷基取代的嘧啶基吡咯烷化合物，可以调节蛋白激酶的活性，因此在治疗由失调的蛋白激酶活性引起的疾病方面具有用途，特别是Jak和/或Src家族激酶。本发明还提供了制备这些化合物的方法，包括这些化合物的药物组合物，以及利用这些化合物或含有它们的药物组合物治疗疾病的方法。
• Substituted piperidines, medicaments containing these compounds, and methods for the production thereof
  申请人：——

  公开号：US20030212057A1

  公开（公告）日：2003-11-13

  The present invention relates to substituted piperidines of general formula 1 wherein A 1 , A 2 , R, R 1 and R 2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及通式1中的取代哌啶，其中A1，A2，R，R1和R2的定义如权利要求书1中所述，其互变异构体，对映异构体，混合物和盐，特别是与无机或有机酸或碱的生理上可接受的盐，具有有价值的药理学特性，特别是CGRP-拮抗特性，含有这些化合物的制药组合物，它们的用途和制备它们的方法。
• ALKYNYL SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASES INHIBITORS
  申请人：Brasca Maria Gabriella

  公开号：US20140194406A1

  公开（公告）日：2014-07-10

  The present invention relates to alkynyl substituted pyrimidinyl-pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak and/or Src family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

  本发明涉及烷基取代的嘧啶基-吡咯烷酮化合物，这些化合物可以调节蛋白激酶的活性，因此在治疗由蛋白激酶活性失调引起的疾病，特别是Jak和/或Src家族激酶方面具有用途。本发明还提供了制备这些化合物的方法，包括这些化合物的制药组合物，以及利用这些化合物或含有它们的制药组合物治疗疾病的方法。
• Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors
  申请人：Brasca Maria Gabriella

  公开号：US08912200B2

  公开（公告）日：2014-12-16

  The present invention relates to alkynyl substituted pyrimidinyl-pyrrole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Jak and/or Src family kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.

  本发明涉及烷基取代的嘧啶基-吡咯烷酮类化合物，其调节蛋白激酶的活性，因此可用于治疗由失调的蛋白激酶活性引起的疾病，特别是Jak和/或Src家族激酶。本发明还提供了制备这些化合物的方法，包括这些化合物的药物组合物，以及利用这些化合物或含有它们的药物组合物治疗疾病的方法。