N-庚基脲 | 42955-46-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: N-庚基脲
• 英文名称: heptylurea
• 英文别名: n-heptylurea；heptyl urea；heptyl-urea；Heptyl-harnstoff；N-n-Heptyl-harnstoff；N-Heptylharnstoff
• CAS: 42955-46-4
• 化学式: C₈H₁₈N₂O
• 分子量: 158.244
• InChiKey: LDNJCDRFTFLQLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-庚基脲 在 sodium hydroxide 作用下， 反应 3.0h， 以90%的产率得到庚胺
  参考文献：
  名称：

  Oxidation of primary amines by potassium ferricyanide

  摘要：

  DOI：

  10.1007/bf00957714
• 作为产物：
  描述：

  N-heptyl-N'-octanoyl-urea 在 硫酸 作用下， 生成 N-庚基脲
  参考文献：
  名称：

  Montagne, Bulletin de la Societe Chimique de France, 1947, p. 127

  摘要：

  DOI：

文献信息

• [EN] ANDROGEN RECEPTOR PROTEIN DEGRADERS<br/>[FR] AGENTS DE DÉGRADATION DE PROTÉINE RÉCEPTEUR DES ANDROGÈNES
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2020142228A1

  公开（公告）日：2020-07-09

  The present disclosure provides compounds represented by Formula (I): A—L—B (I), and the salts or solvates thereof, wherein A, L, and B are as defined in the specification. Compounds having Formula (I) are androgen receptor degraders useful for the treatment of cancer.

  本公开提供由化学式（I）表示的化合物：A—L—B（I），以及其盐或溶剂合物，其中A、L和B如规范中定义。具有化学式（I）的化合物是雄激素受体降解剂，用于癌症治疗。
• Microwave-Assisted Synthesis of N-Monosubstituted Urea Derivatives
  作者：Lidia De Luca、Andrea Porcheddu、Giampaolo Giacomelli、Irene Murgia

  DOI：10.1055/s-0030-1258553

  日期：2010.10

  An easy and rapid procedure for the preparation of N-monosubstituted ureas via reaction between potassium cyanate and a wide range of amines is described. The procedure was performed under microwave irradiation using water as solvent. This methodology is particularly attractive since it provides ureas in high yield and purity.

  描述了一种通过氰酸钾和多种胺之间的反应制备 N-单取代脲的简单快速的方法。该程序在微波辐射下使用水作为溶剂进行。这种方法特别有吸引力，因为它提供了高产率和纯度的尿素。
• A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins
  作者：Giulio G Muccioli、Jacques H Poupaert、Johan Wouters、Bernadette Norberg、Wolfgang Poppitz、Gerhard K.E Scriba、Didier M Lambert

  DOI：10.1016/s0040-4020(03)00033-4

  日期：2003.2

  The present paper describes studies on the synthesis of the antiepileptic drug phenytoin, and of structurally related derivatives. First, the influence of the solvent has been investigated in the microwave-assisted synthesis of the drug, resulting in a yield improvement and a cleaner reaction. Second, a two-step reaction is described to synthesize selectively and in high yields phenytoin. The first

  本文描述了抗癫痫药苯妥英及其结构相关衍生物的合成研究。首先，已经在微波辅助合成药物中研究了溶剂的影响，从而提高了收率，并使反应更清洁。第二，描述了两步反应以选择性地且高产率地合成苯妥​​英。第一步是用微波活化苯甲酰与硫脲的反应，第二步是用过氧化氢将所得的2-硫代乙内酰脲转化为苯妥英钠。此外，微波活化是合成3-烷基化苯妥英衍生物的非常方便的方法，与以前报道的使用烷基化剂的方法相比，微波活化的方法更具选择性。
• METHOD OF ENHANCING CELLULAR PRODUCTION OF MOLECULAR CHAPERONE, HYDROXYLAMINE DERIVATIVES USEFUL FOR ENHANCING THE CHAPERONE PRODUCTION AND THE PREPARATION THEREOF
  申请人：Vígh László

  公开号：US20100267711A1

  公开（公告）日：2010-10-21

  A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.

  本发明提供了一种通过细胞增加分子伴侣的表达和/或增强细胞中分子伴侣活性的方法。该方法包括使用一定量的某种羟胺衍生物处理受到诱导细胞分子伴侣表达的生理应激的细胞，以增加应激。或者，在细胞暴露于诱导其表达分子伴侣的生理应激之前，可以向细胞中注入羟胺衍生物。最好，接受羟胺衍生物处理的细胞是真核细胞。羟胺衍生物对应于公式（I）或（II）。本发明还提供了落在公式（I）和（II）范围内的新羟胺衍生物，以及包含该化合物的药物和/或化妆品组合物。
• Process for preparation of metallic bottles
  申请人：TOYO SEIKAN KAISHA LIMITED

  公开号：EP0076634A1

  公开（公告）日：1983-04-13

  Disclosed is a process for the preparation of metallic bottles which comprises lap-bonding circumferential open end portions of upper and lower members, each consisting of a formed cup of a metal, said process being characterized by using at least one thermoplastic resin adhesive having a water absorption of less than 2%, as measured at a temperature of 23°C and a relative humidity of 80%, and an elasticity contribution ratio [R(t)t=1] of from 1 x 10-4 to 5 x 10-1, defined by the following formula: wherein J(t)t=1 represents a creep compliance at a time constant of 1 second when the adhesive is caused to creep at a temperature higher by 30°C than the melting point of the adhesive under a shear stress of 50 to 5,000 dyne/cm2, and J(t)rec,t=1 represents an equilibrium recovery creep compliance when the adhesive is caused to creep under the same conditions as described above and the adhesive is then let to recover, and containing in the main or side chain groups at a concentration of 10 to 1400 milliequivalents per 100 g of the adhesive.

  本发明公开了一种制备金属瓶的工艺，该工艺包括搭接粘接上下构件的圆周开口端部，每个构件都由一个成形的金属杯组成，所述工艺的特点是使用至少一种热塑性树脂粘合剂，该粘合剂在温度为23℃和相对湿度为80%的条件下测量，吸水率小于2%，弹性贡献率[R(t)t=1]为1×10-4至5×10-1，由下式定义： 其中，J(t)t=1 代表时间常数为 1 秒时的蠕变顺应性，即在剪切应力为 50 至 5000 达因/厘米2 的条件下，在比粘合剂熔点高 30℃的温度下使粘合剂发生蠕变；J(t)rec,t=1 代表平衡恢复蠕变顺应性，即在与上述相同的条件下使粘合剂发生蠕变，然后让粘合剂恢复，并且在主链或侧链基团中含有 浓度为每 100 克粘合剂 10 至 1400 毫当量。