4-izoproyl-2H-1,2,4-benzothiadiazine-3 (4H)-one 1,1-dioxide | 103930-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻二嗪
• 英文名称: 4-izoproyl-2H-1,2,4-benzothiadiazine-3 (4H)-one 1,1-dioxide
• 英文别名: 1,1-Dioxo-4-propan-2-yl-1lambda6,2,4-benzothiadiazin-3-one；1,1-dioxo-4-propan-2-yl-1λ6,2,4-benzothiadiazin-3-one
• CAS: 103930-29-6
• 化学式: C₁₀H₁₂N₂O₃S
• 分子量: 240.283
• InChiKey: YYGLLHQTZYOXBT-UHFFFAOYSA-N

物化性质

• 密度：
  1.345±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-izoproyl-2H-1,2,4-benzothiadiazine-3 (4H)-one 1,1-dioxide 在 五氯化磷 、 一水合肼 作用下， 以 氯仿 为溶剂， 反应 0.5h， 生成 (4-Isopropyl-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-hydrazine
  参考文献：
  名称：

  Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity

  摘要：

  In an effort to develop new and more effective therapies to treat tuberculosis, a series of benzothiadiazine 1,1-dioxide derivatives were synthesized and their in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare was evaluated. One of the compounds, 8c, exhibited potent anti-tubercular activity, particularly for the resistant strains and thus prompted us to investigate its in vivo profile. However, the in vivo testing in a mouse model of tuberculosis infection did not show significant anti-tubercular activity, probably because of its poor bioavailability. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.08.063
• 作为产物：
  描述：

  在 三氯化铝 作用下， 反应 0.5h， 生成 4-izoproyl-2H-1,2,4-benzothiadiazine-3 (4H)-one 1,1-dioxide
  参考文献：
  名称：

  Anti-tubercular agents. Part 3. Benzothiadiazine as a novel scaffold for anti-Mycobacterium activity

  摘要：

  In an effort to develop new and more effective therapies to treat tuberculosis, a series of benzothiadiazine 1,1-dioxide derivatives were synthesized and their in vitro activity against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium intracellulare was evaluated. One of the compounds, 8c, exhibited potent anti-tubercular activity, particularly for the resistant strains and thus prompted us to investigate its in vivo profile. However, the in vivo testing in a mouse model of tuberculosis infection did not show significant anti-tubercular activity, probably because of its poor bioavailability. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.08.063

文献信息

• Stereospecific Radical Polymerization of a Side‐Chain Transformable Bulky Acrylamide Monomer and Subsequent Post‐Polymerization Modification for Syntheses of Isotactic Polyacrylate and Polyacrylamide
  作者：Yuehang Pan、Makoto Ouchi

  DOI：10.1002/anie.202308855

  日期：2023.8.28

  A pendant-transformable bulky acrylamide monomer was designed for the synthesis of a series of isotactic poly(alkyl acrylamide)s and poly(methyl acrylate). The stereospecific radical polymerization of the special monomer was controlled under diluted condition at lower temperature. The pendant underwent subsequent quantitative aminolysis and alcoholysis post-polymerization modification.

  设计了一种可悬垂转化的大体积丙烯酰胺单体，用于合成一系列全同立构聚（烷基丙烯酰胺）和聚（丙烯酸甲酯）。特殊单体的立体定向自由基聚合在较低温度下的稀释条件下进行控制。悬垂物随后进行定量氨解和醇解聚合后改性。
• Reddy; Kamal; Bhaskar Rao, European Journal of Medicinal Chemistry, 1986, vol. 21, # 2, p. 177 - 179
  作者：Reddy、Kamal、Bhaskar Rao、Sattur

  DOI：——

  日期：——
• REDDY, A. V. N.;KAMAL, A.;BHASKAR, RAO, A.;SATTUR, P. B., EUR. J. MED. CHEM., 1986, 21, N 2, 177-179
  作者：REDDY, A. V. N.、KAMAL, A.、BHASKAR, RAO, A.、SATTUR, P. B.

  DOI：——

  日期：——