2--chromanon-(4) | 88590-13-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2--chromanon-(4)
• 英文别名: 2-Quinolin-2-yl-2,3-dihydrochromen-4-one
• CAS: 88590-13-0
• 化学式: C₁₈H₁₃NO₂
• 分子量: 275.307
• InChiKey: QOFIKFFIWAHLTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(Chinolyl-2)-2-(2-hydroxy-benzoyl)-ethylen 在 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 2--chromanon-(4)
  参考文献：
  名称：

  Corvaisier,A., Bulletin de la Societe Chimique de France, 1962, p. 528 - 535

  摘要：

  DOI：

文献信息

• Organocatalyzed, Photoredox Heteroarylation of 2-Trifluoroboratochromanones via C–H Functionalization
  作者：Jennifer K. Matsui、Gary A. Molander

  DOI：10.1021/acs.orglett.7b00196

  日期：2017.2.17

  Heteroarylation via C-H functiohalization has been synthetically challenging, but such transformations represent an atom-economical and highly convergent route toward complex molecules. Reported herein is a photoredox-catalyzed coupling between 2-trifluoroborato-4-chromanones and various heteroarenes through a Minisci pathway. Mesitylacridinium perchlorate, an organic photocatalyst, proved to be a better photocatalyst than transition-metal counterparts for such transformations. To highlight the utility of this approach, a library of unprecedented heteroaryl-substituted chromanones was generated that was composed of numerous, specifically substituted molecules containing a broad range of functional groups.