3.6-Dimethyl-fluoran | 30982-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3.6-Dimethyl-fluoran
• 英文别名: 3',6'-Dimethylspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 30982-52-6
• 化学式: C₂₂H₁₆O₃
• 分子量: 328.367
• InChiKey: NWGXXELBLAMSTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3.6-Dimethyl-fluoran 在 盐酸 、 甲醇 作用下， 生成 9-(2-methoxycarbonyl-phenyl)-3,6-dimethyl-xanthylium; chloride
  参考文献：
  名称：

  Kehrmann; Knop, Chemische Berichte, 1911, vol. 44, p. 3512

  摘要：

  DOI：
• 作为产物：
  描述：

  荧光素 在 potassium phosphate 、 硫酰氟 、 palladium diacetate 、 三乙胺 、 2-二环己基磷-2',6'-二异丙氧基-1,1'-联苯 作用下， 以 1,4-二氧六环 为溶剂， 反应 14.0h， 生成 3.6-Dimethyl-fluoran
  参考文献：
  名称：

  A late-stage functionalization tool: sulfonyl fluoride mediated deoxymethylation of phenols

  摘要：

  报道了一种高效快速的苯酚去甲基化策略，在反应期间无需纯化。该方案对于广泛的官能团具有容忍度，并且收率高，因此在LFS应用中取得成功。

  DOI：

  10.1039/d2ob01523d

文献信息

• FLUORESCENT PROBES FOR REACTIVE SULFUR SPECIES
  申请人：CHANG Christopher J.

  公开号：US20120329085A1

  公开（公告）日：2012-12-27

  The invention provides reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells.

  本发明提供了一种基于反应的荧光探针，用于活细胞中硫化氢的选择性成像。
• [EN] COMPOUNDS AND METHODS FOR DETECTION OF HYDROGEN PEROXIDE<br/>[FR] COMPOSÉS ET PROCÉDÉS DE DÉTECTION DE PEROXYDE D'HYDROGÈNE
  申请人：UNIV HONG KONG

  公开号：WO2018133859A1

  公开（公告）日：2018-07-26

  Disclosed herein are compounds and methods for using the same for the detection of hydrogen peroxide in situ. The compounds can include compounds of Formula (I), Formula (II), or Formula (III), or a salt thereof, wherein X1 is a monovalent pro-fluorophore or pro-luminophore moiety; X2 is a divalent pro-fluorophore or pro-luminophore moiety; each of A and A' is independently represented by formula (IV) or formula (V) :

  披露的是用于现场检测过氧化氢的化合物及其使用方法。这些化合物可以包括公式(I)、公式(II)或公式(III)的化合物，或其盐，其中X1是单价原荧光体或原发光体基团；X2是二价原荧光体或原发光体基团；A和A'每个独立地由公式(IV)或公式(V)表示：
• Novel Scaffolds for Intracellular Compound Delivery for the Detection of Cancer Cells
  申请人：ISI Life Sciences Inc.

  公开号：US20180036312A1

  公开（公告）日：2018-02-08

  Disclosed are folic acid or pteroic acid conjugates and methods for using such conjugates. The conjugates described herein comprise a chemotherapeutic drug or imaging agent covalently bound thereto through a bond or via a linker that is intracellularly disrupted by, e.g., endogenous enzymes such as esterases, lipases and the like so as to provide for the chemotherapeutic drug free of the folic or pteroic acid.

  本文披露了叶酸或叶酸酰胺共轭物以及使用这种共轭物的方法。这里描述的共轭物包括通过化学键或通过细胞内被内源酶（如酯酶、脂肪酶等）破坏的链接剂与化疗药物或成像剂共价结合在一起，以使得化疗药物不再与叶酸或叶酸酰胺结合。
• Fluorogenic/Fluorescent Probes Derivative from Sulfoxanthene, and Use Thereof
  申请人：bioMérieux

  公开号：US20160146814A1

  公开（公告）日：2016-05-26

  The invention relates to fluorescent/fluorogenic probes of formula (I″) or (II″): wherein Z is chosen between: —NH 2 and —OH, or in the fluorescence quencher group consisting of: —NO 2 ; —N═N—R 1 ; R 1 being any organic group that does not obscure the corresponding azo bond; —NHCO-Pept.; Pept. being a peptide residue or any organic group that does not obscure the corresponding amide bond; —O-Glyc.; Glyc. being a oligoglycoside residue that does not obscure the corresponding glycosidic bond; —O—C(O)—R 2 ; —O—P(O)(OR 2 )(OR 2 ′) and —O—S(O) 2 —R 2 ; R 2 and R 2 ′ being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and R a , R b , R c , R d and R e being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity. It also relates to the use of these fluorescent/fluorogenic probes, for the detection of an enzyme activity, notably in order to identify/discriminate microorganisms in function of their ability to express particular enzyme activities.

  该发明涉及式(I″)或(II″)的荧光/荧光探针： 其中Z在以下选项中选择：—NH2和—OH，或者在荧光猝灭剂基团中选择：—NO2；—N═N—R1；其中R1是任何不遮挡相应偶氮键的有机基团；—NHCO-Pept.；Pept.是肽残基或任何不遮挡相应酰胺键的有机基团；—O-Glyc.；Glyc.是不遮挡相应糖苷键的寡糖苷残基；—O—C(O)—R2；—O—P(O)(OR2)(OR2′)和—O—S(O)2—R2；其中R2和R2′独立地是氢原子或不遮挡相应酯键的有机基团；以及Ra、Rb、Rc、Rd和Re独立地是氢原子或任何不遮挡相应芳基醚键的有机基团，以便不阻止其可能被髓过氧化酶活性水解。 该发明还涉及这些荧光/荧光探针的用途，用于检测酶活性，特别是为了根据微生物表达特定酶活性的能力来识别/区分微生物。
• NbCl₅ -Promoted Synthesis of Fluorescein Dye Derivatives: Spectroscopic and Spectrometric Characterization and Their Application in Dye-Sensitized Solar Cells
  作者：Bruno Henrique Sacoman Torquato da Silva、Bruna Andressa Bregadiolli、Carlos Frederico de Oliveira Graeff、Luiz Carlos da Silva-Filho

  DOI：10.1002/cplu.201600530

  日期：2017.2

  Fluorescein has several applications owing to its properties, such as high molar absorptivity, high fluorescence quantum yield, high photostability, and wavelengths of absorption and emission in the visible region. The syntheses of fluorescein derivatives between phenol and anhydride derivatives by using NbCl5 as a Lewis acid is described. The products have high yields and short reaction times are

  荧光素由于其性质而具有多种应用，例如高摩尔吸收率，高荧光量子产率，高光稳定性以及在可见光区域的吸收和发射波长。描述了通过使用NbCl5作为路易斯酸在苯酚和酸酐衍生物之间合成荧光素衍生物。产物具有高收率并且观察到较短的反应时间。还介绍了这些衍生物的UV / Vis和荧光光谱的研究及其在染料敏化太阳能电池中的应用。