苯并[b][1,5]苯并二氧杂卓-6-酮 | 3580-77-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 中文名称: 苯并[b][1,5]苯并二氧杂卓-6-酮
• 英文名称: depsidone
• 英文别名: 11-Oxo-11H-dibenz<1,4>-dioxepin；2-<2-Hydroxy-phenoxy>-benzoesaeure-lacton；Lacton v. 2'-Hydroxy-2-carboxy-diphenylaether；11-Oxo-11H-benzo<1,4>-dioxepin；dibenzo[b,e][1,4]dioxepin-11-one；11H-dibenzo (b,e)-1,4-dioxepine-11-one；Dibenzo[b,e][1,4]dioxepin-11-on；benzo[b][1,4]benzodioxepin-6-one
• CAS: 3580-77-6
• 化学式: C₁₃H₈O₃
• 分子量: 212.205
• InChiKey: YCJBWNIROIXYPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  苯并[b][1,5]苯并二氧杂卓-6-酮 生成 二苯并呋喃
  参考文献：
  名称：

  LELE S. R.; HOSANGADI B. D., INDIAN J. CHEM., 1978, B 16, NO 5, 415-416

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-羟基-苯氧基)-苯甲酸 在 乙酸酐 、 ice water 、 乙醚 、 碳酸氢钠 、 氯化铵 、 magnesium sulfate 作用下， 以 乙酸酐 为溶剂， 反应 8.0h， 生成 苯并[b][1,5]苯并二氧杂卓-6-酮
  参考文献：
  名称：

  Heptacyclic compounds and the pharmaceutical uses thereof for preventing and treating diabetes and metabolic syndrome

  摘要：

  本发明揭示了一类七环化合物在制备用于预防和治疗糖尿病和代谢综合征的配方中的新用途；本发明还揭示了一类新的七环化合物；本发明还揭示了制备七环化合物和含有七环化合物的组合物的方法。本发明的七环化合物可用于有效地预防或治疗糖尿病和代谢综合征等疾病。

  公开号：

  US08158623B2

文献信息

• Tricyclic ethers, their process of preparation and their use as medicines
  申请人：Science Union et Cie

  公开号：US04459306A1

  公开（公告）日：1984-07-10

  This invention relates to novel tricyclic ethers, pharmaceutically acceptable addition salts and optical isomers therefrom. The compounds described herein are useful as psychotropic agents in the treatment of depression and anxiety. Also included herein are methods of preparing said compounds, pharmaceutical compositions including them and methods of treating human or animal beings by administering these pharmaceutical compositions.

  本发明涉及新型三环醚，其药学上可接受的加合物盐和其光学异构体。本文所描述的化合物在治疗抑郁症和焦虑症的精神药物中具有用途。本文还包括制备这些化合物的方法，包括它们的药物组成物和通过给予这些药物组成物治疗人类或动物的方法。
• [EN] MENTHOL SUBSTITUTED ANTITHROMBOTIC PAI-1 INHIBITORS<br/>[FR] INHIBITEURS DE FACTEUR PAI-1 ANTITHROMBOTIQUE A BASE DE MENTHOL SUBSTITUE
  申请人：SCHERING AG

  公开号：WO2003080564A1

  公开（公告）日：2003-10-02

  This invention is directed to menthol-substituted compounds and their pharmaceutically acceptable salts which are useful as antithrombotic agents by inhibiting plasminogen activator inhibitor-1 (PAI-1). In addition, the present invention relates to pharmaceutical compositions and their pharmaceutically acceptable salts, containing the menthol substituted compounds, derivatives of the menthol substituted compounds, and methods of using the compounds to treat disease-states characterized by thrombotic activity.

  本发明涉及替代薄荷醇化合物及其药学上可接受的盐，其通过抑制纤溶酶原激活剂抑制物-1（PAI-1）而有用作为抗血栓剂。此外，本发明还涉及含有替代薄荷醇化合物、替代薄荷醇化合物衍生物的药物组合物及其药学上可接受的盐，并且使用这些化合物治疗由血栓活性所表现的疾病状态的方法。
• HEPTACYCLIC COMPOUNDS AND THE PHARMACEUTICAL USES THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLIC SYNDROME
  申请人：Shen Jianhua

  公开号：US20100173905A1

  公开（公告）日：2010-07-08

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类七环化合物在制备用于预防和治疗糖尿病和代谢综合症的配方中的新用途；本发明还公开了一类新的七环化合物；本发明还公开了一种制备七环化合物和含有七环化合物的组成物的方法。本发明的七环化合物可用于有效地预防或治疗糖尿病和代谢综合症等疾病。
• COMPOUNDS WITH 7-MEMBER CYCLE AND THE PHARMACEUTICAL USE THEREOF FOR PREVENTING AND TREATING DIABETES AND METABOLISM SYNDROME
  申请人：Shanghai Institute of Materia Medica, Chinese Academy of Sciences

  公开号：EP2199295A1

  公开（公告）日：2010-06-23

  The invention discloses a new use of a class of heptacyclic compounds in the preparation of formulations for the prevention and treatment of diabetes and metabolic syndromes; the present invention also discloses a new class of heptacyclic compounds; the present invention also discloses a process for preparing the heptacyclic compounds and a composition containing the same. The heptacyclic compounds of the present invention can be used to effectively preventing or treating diseases such as diabetes and metabolic syndromes.

  本发明公开了一类庚环化合物在制备预防和治疗糖尿病和代谢综合征的制剂中的新用途；本发明还公开了一类新的庚环化合物；本发明还公开了制备庚环化合物和含有庚环化合物的组合物的工艺。本发明的庚环化合物可用于有效预防或治疗糖尿病和代谢综合征等疾病。
• EP2199295
  申请人：——

  公开号：——

  公开（公告）日：——