2-(2-{[(dimethoxytrityl)oxy]ethoxy}ethoxy)ethanol | 146669-11-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2-(2-{[(dimethoxytrityl)oxy]ethoxy}ethoxy)ethanol
• 英文别名: O-(4,4'-dimethoxytrityl)triethyleneglycol；8-dimethoxytrityloxy-3,6-dioxaoctanol；O1-(Dimethoxytrityl)triethylene glycol；2-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethoxy]ethoxy]ethanol
• CAS: 146669-11-6
• 化学式: C₂₇H₃₂O₆
• 分子量: 452.547
• InChiKey: QUZOXUWFELICHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(2-{[(dimethoxytrityl)oxy]ethoxy}ethoxy)ethanol 在 sodium periodate 作用下， 以 丙酮 为溶剂， 反应 16.0h， 生成 三乙二醇
  参考文献：
  名称：

  Selective Cleavage of O-(Dimethoxytrityl) Protecting Group with Sodium Periodate

  摘要：

  在水有机溶剂中，过碘酸钠在温和的反应条件下选择性地去除了O-(二甲氧基三苯甲基)保护基团。利用核苷衍生物进行了裂解的选择性研究，这些核苷衍生物受到核苷和核苷酸化学中常用的各种基团的保护。

  DOI：

  10.1135/cccc20020502
• 作为产物：
  描述：

  4,4'-双甲氧基三苯甲基氯 、 三乙二醇 在 吡啶 作用下， 反应 4.0h， 生成 2-(2-{[(dimethoxytrityl)oxy]ethoxy}ethoxy)ethanol
  参考文献：
  名称：

  Binding of Aminoglycoside Antibiotics with Modified A-site 16S rRNA Construct Containing Non-Nucleotide Linkers

  摘要：

  The design and synthesis of synthetically modified cyclic A-site 16S rRNA construct is reported. The binding characteristics of several members of the aminoglycoside antibiotics with this novel class of synthetically modified A-site 16S rRNA constructs were subsequently investigated. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00760-0

文献信息

• Oligo(2′-O-methylribonucleotides) and their derivatives: IV. Conjugates of oligo(2′-O-methylribonucleotides) with minor groove binders and intercalators: Synthesis, properties, and application
  作者：D. S. Novopashina、A. N. Sinyakov、V. A. Ryabinin、L. Perrouault、C. Giovannangeli、A. G. Venyaminova、A. S. Boutorine

  DOI：10.1134/s1068162013010081

  日期：2013.3

  Triplex forming 3'-protected pyrimidine oligo(2'-O-methylribonucleotides) containing minor groove binders (MGB) and triplex specific intercalator, benzoindoloquinoline (BIQ), at the 5'-terminus were synthesized. The resulting conjugates formed stable complexes with a target dsDNA due to the simultaneous binding to the minor and major grooves and BIQ intercalation. The dissociation constants and the thermal stability were evaluated for the conjugate complexes with the model dsDNA corresponding to the polypurine tract (PPT) of the nef and pol genes from the HIV proviral genome. The conjugation of oligo(2'-O-methylribonucleotides) with MGB and BIQ was shown to increase the stability of the triple complexes with dsDNA at pH 7.2 and 37A degrees C. Moreover, the intercalator accelerates the process of the complex formation. The dosedependent arrest of the in vitro transcription was demonstrated when a 780-bp DNA fragment containing the polypurine tract was transcribed under the control of T7 promoter in the presence of different concentrations of conjugates of oligo(2'-O-methylribonucleotides) containing MGB and BIQ.
• 2′-<i>C</i>-ALKOXY AND 2′-<i>C</i>-ARYLOXY DERIVATIVES OF<i>N</i>-(2-PHOSPHONOMETHOXYETHYL)-PURINES AND -PYRIMIDINES: SYNTHESIS AND BIOLOGICAL ACTIVITY
  作者：Dominik Rejman、Milena Masojídková、Eric De Clercq、Ivan Rosenberg

  DOI：10.1081/ncn-100105244

  日期：2001.7.31

  A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship within the area of acyclic nucleotide analogues.
• Novel Polynucleotide Synthesis Labeling Chemistry
  申请人：Hartsel A. Stephanie

  公开号：US20080009612A1

  公开（公告）日：2008-01-10

  Methods and compositions for making nucleoside phosphoramidites and nucleic acids, including mono-, di-, and polynucleotides, comprising a linker covalently attached to a levulinyl moiety are provided. A levulinyl-protected linking moiety affords an orthogonal approach to modifying a polynucleotide during or after solid phase synthesis with a molecule of interest, for example, a conjugate or a dye.
• US8026349B2
  申请人：——

  公开号：US8026349B2

  公开（公告）日：2011-09-27
• Selective Cleavage of O-(Dimethoxytrityl) Protecting Group with Sodium Periodate
  作者：Dominik Rejman、Šárka Králíková、Zdeněk Točík、Radek Liboska、Ivan Rosenberg

  DOI：10.1135/cccc20020502

  日期：——

  Sodium periodate in aqueous organic solvents selectively removes, under mild reaction conditions, the O-(dimethoxytrityl) protecting group. Selectivity of the cleavage was studied using the nucleoside derivatives protected by various types of groups commonly used in nucleoside and nucleotide chemistry.

  在水有机溶剂中，过碘酸钠在温和的反应条件下选择性地去除了O-(二甲氧基三苯甲基)保护基团。利用核苷衍生物进行了裂解的选择性研究，这些核苷衍生物受到核苷和核苷酸化学中常用的各种基团的保护。