tris(dibutylaminoglycidyl) isocyanurate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: tris(dibutylaminoglycidyl) isocyanurate
• 英文别名: 1,3,5-Tris[3-(dibutylamino)-2-hydroxypropyl]-1,3,5-triazinane-2,4,6-trione；1,3,5-tris[3-(dibutylamino)-2-hydroxypropyl]-1,3,5-triazinane-2,4,6-trione
• 化学式: C₃₆H₇₂N₆O₆
• 分子量: 685.004
• InChiKey: WOYBSEKDQIVDER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  48
• 可旋转键数：
  30
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  甲基丙烯酸异氰基乙酯 、 tris(dibutylaminoglycidyl) isocyanurate 在 2,6-二叔丁基-4-甲基苯酚 、 二月桂酸二丁基锡 作用下， 生成 2-[[1-[3,5-Bis[3-(dibutylamino)-2-[2-(2-methylprop-2-enoyloxy)ethylcarbamoyloxy]propyl]-2,4,6-trioxo-1,3,5-triazinan-1-yl]-3-(dibutylamino)propan-2-yl]oxycarbonylamino]ethyl 2-methylprop-2-enoate
  参考文献：
  名称：

  [EN] MULTI-PART COMPOSITION HAVING STAGED VISCOSITY PRIOR TO HARDENING
  [FR] COMPOSITION À PLUSIEURS PARTIES AYANT UNE VISCOSITÉ À PLUSIEURS STADES AVANT DURCISSEMENT

  摘要：

  公开号：

  WO2019123260A3
• 作为产物：
  描述：

  二正丁胺 、 1,3,5-三缩水甘油-S-三嗪三酮 以 乙醇 为溶剂， 反应 48.0h， 以90.85%的产率得到tris(dibutylaminoglycidyl) isocyanurate
  参考文献：
  名称：

  [EN] MULTI-PART COMPOSITION HAVING STAGED VISCOSITY PRIOR TO HARDENING
  [FR] COMPOSITION À PLUSIEURS PARTIES AYANT UNE VISCOSITÉ À PLUSIEURS STADES AVANT DURCISSEMENT

  摘要：

  公开号：

  WO2019123260A3

文献信息

• 1,3,5-TRIAZINANE-2,4,6-TRIONE DERIVATIVES AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20140329884A1

  公开（公告）日：2014-11-06

  The present invention provides novel 1,3,5-triazinane-2,4,6-trione derivatives, such as compounds of any one of Formulae (I) and (II), and salts thereof, and methods of preparing the compounds. Also provided are compositions including a compound of the invention and an agent (e.g., an siRNA, mRNA, or plasmid DNA). The present invention also provides methods and kits using the compositions for delivering an agent to a subject (e.g., to the liver, spleen, or lung of the subject) or cell and for treating and/or preventing a range of diseases, such as genetic diseases, proliferative diseases, hematological diseases, neurological diseases, liver diseases, and lung diseases.

  本发明提供了新型的1,3,5-三嗪烷-2,4,6-三酮衍生物，例如公式(I)和(II)中的任一化合物及其盐，并提供了制备这些化合物的方法。还提供了包括本发明化合物和一种药剂(例如siRNA、mRNA或质粒DNA)的组合物。本发明还提供了使用该组合物将药剂传递到受体(例如受体的肝脏、脾脏或肺)或细胞以及治疗和/或预防一系列疾病(例如遗传性疾病、增殖性疾病、血液疾病、神经系统疾病、肝脏疾病和肺部疾病)的方法和试剂盒。
• MULTI-PART DENTAL COMPOSITION HAVING STAGED VISCOSITY PRIOR TO HARDENING
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20200383877A1

  公开（公告）日：2020-12-10

  Disclosed herein are non-aqueous compositions including: a flowable Part A including at least one resin and Reactant A; and a flowable Part B including at least one resin and Reactant B; wherein at least one of flowable Part A and flowable Part B further includes a free radically polymerizable resin; wherein at least one of flowable Part A and flowable Part B further includes a free radical initiator system; wherein flowable Part A and flowable Part B are capable of being mixed to provide a flowable mixed composition; wherein when flowable Part A and flowable Part B are mixed, Reactant A and Reactant B are capable of interacting to cause a non-free radical reaction within a first staging time to provide a first staged stable consistency for the mixed composition; wherein Reactant A comprises an acid and Reactant B comprises a base, and upon mixing flowable Part A and flowable Part B, the Reactant A acid is capable of reacting with the Reactant B base in an ionic acid-base reaction; and wherein the mixed composition having the first staged stable consistency is capable of forming a hardened dental composition upon initiation of free radical polymerization.
• US9315472B2
  申请人：——

  公开号：US9315472B2

  公开（公告）日：2016-04-19
• [EN] MULTI-PART COMPOSITION HAVING STAGED VISCOSITY PRIOR TO HARDENING<br/>[FR] COMPOSITION À PLUSIEURS PARTIES AYANT UNE VISCOSITÉ À PLUSIEURS STADES AVANT DURCISSEMENT
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2019123260A3

  公开（公告）日：2019-09-06