2-(7'-methoxy-1'-naphthyl)propanoic acid | 139633-72-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(7'-methoxy-1'-naphthyl)propanoic acid
• 英文别名: 2-(7-methoxynaphthalen-1-yl)propanoic acid；2-(7-Methoxy-1-naphthyl)propanoic acid
• CAS: 139633-72-0
• 化学式: C₁₄H₁₄O₃
• 分子量: 230.263
• InChiKey: ZJTGRYUHMAIZLW-UHFFFAOYSA-N

物化性质

• 沸点：
  403.9±20.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Ethyl 2-(7-methoxynaphthalen-1-yl)propanoate 在 水 、 lithium hydroxide 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 36.0h， 以96%的产率得到2-(7'-methoxy-1'-naphthyl)propanoic acid
  参考文献：
  名称：

  [EN] SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS
  [FR] DÉRIVÉS DE CARBOXAMIDE AROMATIQUE ET D'URÉE SUBSTITUÉS EN TANT QUE LIGANDS DU RÉCEPTEUR VANILLOÏDE

  摘要：

  这项发明涉及取代芳香族羧酰胺和脲衍生物，以及其制备方法，含有这些化合物的药物组合物，以及利用这些化合物制备药物组合物的用途（式（I））。

  公开号：

  WO2010127855A1

文献信息

• γ-versusα-Substitution in dihydronaphthalene sulphonamides. A novel approach to (±)-Naproxen
  作者：H. J. E. Loewenthal

  DOI：10.1039/c39900000768

  日期：——

  Alkylation of N-alkyl dihydronaphthalene-1-sulphonamides, derived by reduction with Li/liq. NH3, can be directed in certain cases to the naphthalene 3-position, depending mainly on the steric bulk of the N-alkyl group(s).

  通过用Li / liq还原得到的N-烷基二氢萘-1-磺酰胺的烷基化。在某些情况下，NH 3可以直接指向萘的3-位，这主要取决于一个或多个N-烷基的空间体积。
• Substituted Aromatic Carboxamide and Urea Derivatives as Vanilloid Receptor Ligands
  申请人：FRANK Robert

  公开号：US20110003795A1

  公开（公告）日：2011-01-06

  The invention relates to substituted aromatic carboxamide and urea derivatives, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.

  该发明涉及取代芳香族羧酰胺和脲衍生物，其制备过程，含有这些化合物的药物组合物以及利用这些化合物制备药物组合物的用途。
• Metal-ammonia reduction and reductive alkylation of N-alkylnaphthalenesulfonamides. A new route to substituted naphthalenes
  作者：H. J. E. Loewenthal、L. Gottlieb

  DOI：10.1021/jo00035a018

  日期：1992.4

  Conditions have been found for 1,4-reduction of aromatic sulfonamides (conveniently monitored by electrical conductivity), using metals in THF/liquid ammonia on the pre-formed N-lithium salts (BuLi), without concomitant C-S reductive cleavage. The resulting 1,4-dihydro compounds could be alkylated, either in situ (in the case of simple unfunctionalized halides only) or, following isolation, after further N-alkylation and then forming the monoanion, or after forming the dianion of the N-monoalkylated dihydrosulfonamide, generally using as base n-butyllithium (a simple titration procedure). In the former case functionalized electrophiles (bromo esters, chloroformates) could be utilized. The ratio of alpha- to gamma-alkylation was dependent on the method of alkylation, the reaction medium, the nature of the N-alkyl group(s), and whether a monoanion or a dianion served as substrate. Gamma-Alkylation products could in some cases be further alpha-substituted. The alpha-substituted products aromatized, with loss of SO2 and amine, by heating, whereas gamma-substitution products required hydrolysis by aqueous alkali; this greatly facilitated separation where mixtures were formed. Thus, this dihydrosulfonamide route constitutes a novel and nucleophilic route to 1-substituted, 2-substituted, and, notably, 1,3-disubstituted naphthalenes.
• SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS
  申请人：Grünenthal GmbH

  公开号：EP2427436A1

  公开（公告）日：2012-03-14
• US8334315B2
  申请人：——

  公开号：US8334315B2

  公开（公告）日：2012-12-18