1-decyl-piperidine-3-carboxylic acid diethylamide; hydrobromide | 328-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-decyl-piperidine-3-carboxylic acid diethylamide; hydrobromide
• 英文别名: 1-Decyl-piperidin-3-carbonsaeure-diaethylamid; Hydrobromid；1-decyl-3-(N,N-diethylcarbamoyl)piperidine hydrobromide；1-decyl-N,N-diethylpiperidine-3-carboxamide;hydron;bromide
• CAS: 328-07-4
• 化学式: BrH*C₂₀H₄₀N₂O
• 分子量: 405.462
• InChiKey: CZKBSSSIQHATNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  23.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  癸基溴 在 platinum(IV) oxide 氢气 作用下， 以 乙醇 、 丙酮 为溶剂， 25.0 ℃ 、413.69 kPa 条件下， 反应 29.0h， 生成 1-decyl-piperidine-3-carboxylic acid diethylamide; hydrobromide
  参考文献：
  名称：

  设计和合成哌啶-3-羧酰胺作为人类血小板凝集抑制剂。

  摘要：

  使用8种1-烷基（芳烷基）哌酰胺类（5型），33种双-邻酰胺基烷烃和芳烃（6类）和7种N，N'-双（苯甲酰基）-哌嗪（7类）进行了详细的结构活性分析）作为人类血小板聚集的抑制剂。立体因子在确定具有适当程度的疏水性的5型化合物的活性中起着重要作用。6型和7型化合物比相应的5型分子更有效。疏水特性似乎影响6型化合物的活性。哌啶环上的3-取代基对于抗血小板活性是必不可少的。取代基最好是酰胺，其C直接连接在环上。3,5-二取代和2-取代导致活性下降。当两个nipecotoyl环N原子通过一个芳烷基连接并相隔约7 A时，可获得最佳活性。这表明范德华力和pi相互作用可能决定抑制剂与血小板之间的相互作用。最有效的6型抑制剂是α，α'-双[3-（N-乙基-N-丁基氨基甲酰基）哌啶子基]-对二甲苯（6i）。最有效的5型化合物是1-癸基-3-（N，N-二乙基氨基甲酰基）哌啶（5a）。7型化合物哌嗪环上的任何取

  DOI：

  10.1021/jm00001a023

文献信息

• Methods of increasing the efficacy of peroxides
  申请人：——

  公开号：US20040208840A1

  公开（公告）日：2004-10-21

  This invention relates to methods of increasing the efficacy of peroxides such as benzoyl peroxide in the treatment of skin conditions such as acne. In a preferred embodiment, the invention relates to methods of increasing radicals formed by peroxides on/in the skin, more specifically near/in the comedone, for topical use in dermatology. In a specific embodiment, the invention relates to the use of transitional metals such as Cu(1) and ferrous ions to increase the efficacy of peroxides such as benzoyl peroxide. In another embodiment, the invention relates to a method by which a peroxide such as benzoyl peroxide and its activator are added to the skin surface at the same time. In another embodiment, the invention relates to the use of a more soluble form of peroxide such as benzoyl peroxide to increase its efficacy. In another embodiment, the invention relates to the addition of a side chain to a peroxide such as benzoyl peroxide so that it is activated by light. In a further embodiment, the invention relates to the addition of a tertiary amine to a peroxide such as benzoyl peroxide at the time of skin application, to improve the efficacy of the peroxide. In another embodiment, the invention relates to the addition of dapsone or other material to a peroxide such as benzoyl peroxide to improve its efficacy.

  本发明涉及提高过氧化物（如过氧化苯甲酰）治疗皮肤病（如痤疮）疗效的方法。在一个优选的实施方案中，本发明涉及增加过氧化物在皮肤（更具体地说是在粉刺附近）形成的自由基的方法，用于皮肤科的局部使用。在一个具体的实施方案中，本发明涉及使用过渡金属如铜（1）和亚铁离子来提高过氧化物如过氧化苯甲酰的功效。在另一个实施方案中，本发明涉及一种将过氧化物（如过氧化苯甲酰）及其活化剂同时添加到皮肤表面的方法。在另一个实施方案中，本发明涉及使用过氧化苯甲酰等过氧化物的更易溶形式来提高其功效。在另一个实施方案中，本发明涉及在过氧化苯甲酰等过氧化物中添加侧链，使其被光激活。在另一个实施方案中，本发明涉及在皮肤使用过氧化苯甲酰等过氧化物时添加叔胺，以提高过氧化物的功效。在另一个实施方案中，本发明涉及向过氧化苯甲酰等过氧化物中添加达泊松或其他材料，以提高其功效。
• METHODS OF ENHANCING PEROXIDE ACTIVITY
  申请人：JR Chem, LLC

  公开号：EP2403533A1

  公开（公告）日：2012-01-11
• Benzoyl peroxide compositions having increased potency
  申请人：Burkhart G. Craig

  公开号：US20050256200A1

  公开（公告）日：2005-11-17

  A benzoyl peroxide composition having increased potency includes benzoyl peroxide, a tertiary amine and/or a transition metal, and a base that increases radicals formed by the peroxide.
• Treatment methods with peroxides and tertiary amines
  申请人：Burkhart N. Craig

  公开号：US20070244195A1

  公开（公告）日：2007-10-18

  This invention relates to methods of increasing the efficacy of peroxides such as benzoyl peroxide in the treatment of skin conditions such as acne. In a preferred embodiment, the invention relates to methods of increasing radicals formed by peroxides on/in the skin, more specifically near/in the comedone, for topical use in dermatology. In a specific embodiment, the invention relates to the use of transitional metals such as Cu(l) and ferrous ions to increase the efficacy of peroxides such as benzoyl peroxide. In another embodiment, the invention relates to a method by which a peroxide such as benzoyl peroxide and its activator are added to the skin surface at the same time. In another embodiment, the invention relates to the use of a more soluble form of peroxide such as benzoyl peroxide to increase its efficacy. In another embodiment, the invention relates to the addition of a side chain to a peroxide such as benzoyl peroxide so that it is activated by light. In a further embodiment, the invention relates to the addition of a tertiary amine to a peroxide such as benzoyl peroxide at the time of skin application, to improve the efficacy of the peroxide. In another embodiment, the invention relates to the addition of dapsone or other material to a peroxide such as benzoyl peroxide to improve its efficacy.
• US4657917A
  申请人：——

  公开号：US4657917A

  公开（公告）日：1987-04-14