(-)戈米辛L1 | 82425-43-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 中文名称: (-)戈米辛L1
• 英文名称: (-)-gomisin L₁
• 英文别名: Gomisin L1, (-)-；(9S,10R)-4,5,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-3-ol
• CAS: 82425-43-2；82467-50-3；95152-95-7；102681-52-7
• 化学式: C₂₂H₂₆O₆
• 分子量: 386.445
• InChiKey: OGJPBGDUYKEQLA-NWDGAFQWSA-N

物化性质

• 沸点：
  568.6±50.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 (-)戈米辛L1 以4.5 mg的产率得到schisandrin A
  参考文献：
  名称：

  五味子的木脂素作为血小板活化因子拮抗剂的构效关系。

  摘要：

  我们研究了五味子的木脂素及其衍生物作为血小板活化因子（PAF）拮抗剂的构效关系。在木脂素中显示出强活性，其在C-6处没有酯基，在C-7处没有羟基或亚甲基二氧基部分并且具有R-联苯基构型。五倍子A的衍生物6（7）-脱氢五倍子A表现出最高的活性（IC50，2.1x10（-6）M）。

  DOI：

  10.1248/bpb.22.265

文献信息

• The Constituents of Schizandra chinensis Baill. X. The Structures of .GAMMA.-schizandrin and four new lignans,(-)-gomisins L1 and L2,(.+-.)-gomisin M1 and (+)-gomisin M2.
  作者：YUKINOBU IKEYA、HEIHACHIRO TAGUCHI、ITIRO YOSIOKA

  DOI：10.1248/cpb.30.132

  日期：——

  Four new dibenzocyclooctadiene lignans, named (-)-gomisins L1 (6) and L3 (7), (±)-gomisin M1 (8) and (+)-gomisin M2 (9), were isolated from the fruits of Schizandra chinensis BAILL. (Schizandraceae). Their absolute structures were elucidated by means of chemical and spectral studies. The stereostructure of γ-schizandrin (1, dl-form), the plane structure of which had already been suggested by Kochetkov et al. and Liu et al., was also elucidated on the basis of chemical and spectral studies.

  从五味子果实中分离出四种新的二苯并环辛二烯木脂素，分别命名为(-)-大黄素 L1 (6)和 L3 (7)、(±)-大黄素 M1 (8)和(+)-大黄素 M2 (9)。(五味子科）果实中分离得到。通过化学和光谱研究阐明了它们的绝对结构。Kochetkov 等人和 Liu 等人也根据化学和光谱研究阐明了 γ-五味子素（1，dl-form）的立体结构，其平面结构已被 Kochetkov 等人和 Liu 等人提出。
• Methods of application of chemical compounds having therapeutic activities in treating cancers
  申请人：Hu Xun

  公开号：US20050282910A1

  公开（公告）日：2005-12-22

  Methods of application of a class of compounds with a pharmacophore of dibenzocyclooctadiene in the preparation of anticancer medications, and particularly for the preparation of medications for the treatment of P-glycoprotein-mediated multidrug resistant (MDR) cancer and non-P-glycoprotein-mediated MDR cancer, such as multidrug resistant associated protein MRP1-mediated cancer. Methods of increasing the efficacy of anticancer agents are further disclosed. The class of compounds are of a potency to effectively reverse MDR cancer by inhibiting the drug transport activity of an ABC drug transporter, increase the intracellular accumulation of an anticancer agent in MDR cancer cells, enhance apoptosis of cancer cells induced by an anticancer agent, and directly kill cancer cells. The aforementioned methods of application of the present disclosure provide much potential for the treatment of cancer. Mass production of medications incorporating these chemical compounds will treat a significant number of patients affected by the condition of MDR cancer.
• USE OF 2,2'-CYCLOLIGNANS FOR INDUCING, RESTORING OR STIMULATING THE PIGMENTATION OF THE SKIN, HAIR OR HAIRS
  申请人：BERNARD Philippe

  公开号：US20110046217A1

  公开（公告）日：2011-02-24

  The invention relates to the use of 2,2′-cyclolignanes in the cosmetic or pharmaceutical field for inducing, restoring or stimulating the pigmentation of the skin, hair or hairs.
• RADIOSENSITIZER COMPOSITIONS COMPRISING SCHISANDRA CHINENSIS(TURCZ.)BAILL AND METHODS FOR USE
  申请人：LAI I Cheng

  公开号：US20110124741A1

  公开（公告）日：2011-05-26

  The present invention provides a method of potentiating radiation therapy for treatment of a cancer or tumor comprising administrating to a subject in need thereof a therapeutically effective amount of a radiosensitizer in combination of a radiation therapy to a locus of the cancer or tumor, wherein the radiosensitizer is an extract of Schisandra chinensis (Turcz.) Baill, or the active ingredient isolated therefrom, particularly Schisandrin B.
• Structure-Activity Relationships of Lignans from Schisandra chinensis as Platelet Activating Factor Antagonists.
  作者：Im Seon LEE、Keun Young JUNG、Sei Ryang OH、Si Hyung PARK、Kyung Seop AHN、Hyeong-Kyu LEE

  DOI：10.1248/bpb.22.265

  日期：——

  structure-activity relationships of lignans from Schisandra chinensis and their derivatives as platelet activating factor (PAF) antagonists. Strong activity was shown in lignans without an ester group at C-6, a hydroxyl group at C-7 or a methylene dioxy moiety and with an R-biphenyl configuration. 6(7)-Dehydroschisandrol A, a derivative of schisandrol A, showed the highest activity (IC50, 2.1x10(-6) M) in this

  我们研究了五味子的木脂素及其衍生物作为血小板活化因子（PAF）拮抗剂的构效关系。在木脂素中显示出强活性，其在C-6处没有酯基，在C-7处没有羟基或亚甲基二氧基部分并且具有R-联苯基构型。五倍子A的衍生物6（7）-脱氢五倍子A表现出最高的活性（IC50，2.1x10（-6）M）。