戈米辛L2 | 82425-44-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 单宁
• 中文名称: 戈米辛L2
• 中文别名: 戈米辛 L2
• 英文名称: (-)-gomisin L₂
• 英文别名: Gomisin L2, (-)-；(9S,10R)-3,4,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-5-ol
• CAS: 82425-44-3
• 化学式: C₂₂H₂₆O₆
• 分子量: 386.445
• InChiKey: BVMLGLOHSDNEJG-NWDGAFQWSA-N

物化性质

• 沸点：
  568.6±50.0 °C(Predicted)
• 密度：
  1.195±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 储存条件：
  存储条件：2-8℃，干燥，密闭。

反应信息

• 作为反应物：
  描述：

  戈米辛L2 、 4-溴苯甲酰氯 以 吡啶 为溶剂， 以115 mg的产率得到[(9S,10R)-3,4,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-5-yl] 4-bromobenzoate
  参考文献：
  名称：

  The Constituents of Schizandra chinensis Baill. X. The Structures of .GAMMA.-schizandrin and four new lignans,(-)-gomisins L1 and L2,(.+-.)-gomisin M1 and (+)-gomisin M2.

  摘要：

  从五味子果实中分离出四种新的二苯并环辛二烯木脂素，分别命名为(-)-大黄素 L1 (6)和 L3 (7)、(±)-大黄素 M1 (8)和(+)-大黄素 M2 (9)。(五味子科）果实中分离得到。通过化学和光谱研究阐明了它们的绝对结构。Kochetkov 等人和 Liu 等人也根据化学和光谱研究阐明了 γ-五味子素（1，dl-form）的立体结构，其平面结构已被 Kochetkov 等人和 Liu 等人提出。

  DOI：

  10.1248/cpb.30.132
• 作为产物：
  描述：

  [(9S,10R)-3,4,19-trimethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaen-5-yl] 4-bromobenzoate 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以48 mg的产率得到戈米辛L2
  参考文献：
  名称：

  The Constituents of Schizandra chinensis Baill. X. The Structures of .GAMMA.-schizandrin and four new lignans,(-)-gomisins L1 and L2,(.+-.)-gomisin M1 and (+)-gomisin M2.

  摘要：

  从五味子果实中分离出四种新的二苯并环辛二烯木脂素，分别命名为(-)-大黄素 L1 (6)和 L3 (7)、(±)-大黄素 M1 (8)和(+)-大黄素 M2 (9)。(五味子科）果实中分离得到。通过化学和光谱研究阐明了它们的绝对结构。Kochetkov 等人和 Liu 等人也根据化学和光谱研究阐明了 γ-五味子素（1，dl-form）的立体结构，其平面结构已被 Kochetkov 等人和 Liu 等人提出。

  DOI：

  10.1248/cpb.30.132

文献信息

• POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS
  申请人：Hans, Joachim

  公开号：EP2812005A1

  公开（公告）日：2014-12-17
• USE OF 2,2'-CYCLOLIGNANS FOR INDUCING, RESTORING OR STIMULATING THE PIGMENTATION OF THE SKIN, HAIR OR HAIRS
  申请人：BERNARD Philippe

  公开号：US20110046217A1

  公开（公告）日：2011-02-24

  The invention relates to the use of 2,2′-cyclolignanes in the cosmetic or pharmaceutical field for inducing, restoring or stimulating the pigmentation of the skin, hair or hairs.
• RADIOSENSITIZER COMPOSITIONS COMPRISING SCHISANDRA CHINENSIS(TURCZ.)BAILL AND METHODS FOR USE
  申请人：LAI I Cheng

  公开号：US20110124741A1

  公开（公告）日：2011-05-26

  The present invention provides a method of potentiating radiation therapy for treatment of a cancer or tumor comprising administrating to a subject in need thereof a therapeutically effective amount of a radiosensitizer in combination of a radiation therapy to a locus of the cancer or tumor, wherein the radiosensitizer is an extract of Schisandra chinensis (Turcz.) Baill, or the active ingredient isolated therefrom, particularly Schisandrin B.
• [EN] POLYHYDROXYLATED PENTACYCLIC TRITERPENE ACIDS AS HMG-COA REDUCTASE INHIBITORS<br/>[FR] ACIDES TRITERPÈNES PENTACYLIQUES POLYHYDROXYLÉS EN TANT QU'INHIBITEURS D'HMG-COA RÉDUCTASE
  申请人：HANS JOACHIM

  公开号：WO2013171100A1

  公开（公告）日：2013-11-21

  The present invention relates to certain polyhydroxylated pentacyclic triterpene acids of formula (I) for use as HMG-Co A reductase inhibitors in the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to a reduction of the HMG-Co A reductase activity in a mammal, preferably a human being. The present invention further relates to certain mixtures and plant extracts comprising euscaphic acid and tormentic acid, wherein the amount of euscaphic acid to tormentic acid exceeds a certain ratio. Further, the present invention also relates to a formulation, preferably pharmaceutical or nutraceutical formulation, comprising one or more of said compounds of formula (I), a composition according to the present invention or a plant extract according to the present invention. Also, the present invention relates to a process for obtaining certain polyhydroxylated pentacyclic triterpene acids of formula (I), a composition according to the present invention or a plant extract according to the present invention.
• The Constituents of Schizandra chinensis Baill. X. The Structures of .GAMMA.-schizandrin and four new lignans,(-)-gomisins L1 and L2,(.+-.)-gomisin M1 and (+)-gomisin M2.
  作者：YUKINOBU IKEYA、HEIHACHIRO TAGUCHI、ITIRO YOSIOKA

  DOI：10.1248/cpb.30.132

  日期：——

  Four new dibenzocyclooctadiene lignans, named (-)-gomisins L1 (6) and L3 (7), (±)-gomisin M1 (8) and (+)-gomisin M2 (9), were isolated from the fruits of Schizandra chinensis BAILL. (Schizandraceae). Their absolute structures were elucidated by means of chemical and spectral studies. The stereostructure of γ-schizandrin (1, dl-form), the plane structure of which had already been suggested by Kochetkov et al. and Liu et al., was also elucidated on the basis of chemical and spectral studies.

  从五味子果实中分离出四种新的二苯并环辛二烯木脂素，分别命名为(-)-大黄素 L1 (6)和 L3 (7)、(±)-大黄素 M1 (8)和(+)-大黄素 M2 (9)。(五味子科）果实中分离得到。通过化学和光谱研究阐明了它们的绝对结构。Kochetkov 等人和 Liu 等人也根据化学和光谱研究阐明了 γ-五味子素（1，dl-form）的立体结构，其平面结构已被 Kochetkov 等人和 Liu 等人提出。