ethyl orthoacetate | 58924-88-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 原羧酸衍生物
• 英文名称: ethyl orthoacetate
• 英文别名: Orthoessigsaureethylester；1-ethoxyethane-1,1-diol
• CAS: 58924-88-2
• 化学式: C₄H₁₀O₃
• 分子量: 106.122
• InChiKey: OZBQTZGDRBLTSM-UHFFFAOYSA-N

物化性质

• 沸点：
  22.8±20.0 °C(Predicted)
• 密度：
  1.105±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl orthoacetate 在 对甲苯磺酸一水合物 三乙胺 作用下， 以 2-氨基-3-羟基吡啶 为溶剂， 生成 2-甲基[1,3]噁唑并[4,5-b]吡啶
  参考文献：
  名称：

  Method for optical measurement of multi-stranded nucleic acid using cyanine dyes

  摘要：

  公开号：

  EP1362894B1
• 作为试剂：
  描述：

  甲醇 、 反式-3-己烯-1-醇 、 一氧化碳 在 palladium dichloride ethyl orthoacetate 、 methyloxirane 、 copper dichloride 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以63%的产率得到threo-2-<1-(methoxycarbonyl)propyl>-γ-butyrolactone
  参考文献：
  名称：

  Palladium(II)-catalyzed carbonylation of 3-buten-1-ols and 3-butyn-1-ols: an efficient synthesis of .gamma.-butyrolactones

  摘要：

  Palladium(II)-catalyzed dicarbonylation of 3-buten-1-ols (1) in the presence of propylene oxide and ethyl orthoacetate in methanol-dichloromethane under carbon monoxide at atmospheric pressure afforded alpha-[(methoxycarbonyl)methyl]-gamma-butyrolactones (2) in good yields. This dicarbonylation reaction occurs via stereospecific cis addition. Under similar conditions, 4-(trimethylsilyl)-3-butyn-1-ols (4a and 4b) undergo dicarbonylation to provide cis-dicarbonylated alpha-methylene-gamma-butyrolactones (5a and 5b, respectively). 4-Alkyl-and 4-aryl-3-butyn-1-ols (4c-g), on the other hand, undergo trans alkoxycarbonylation across the triple bond and selectively furnish E tetrasubstituted alpha-methylene-gamma-butyrolactones (6).

  DOI：

  10.1021/jo00003a036

文献信息

• Methods for the production of 4H-s-triazolo[4,3-a][1,4]benzodiazepine
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04082764A1

  公开（公告）日：1978-04-04

  The title compounds are prepared by reacting a 3-amino-3,4-dihydro-4-hydroxy-4-phenylquinazoline with a reactive derivative of a halogenoacetic acid, reacting the resultant halogenoacetyl derivative with a weak acid, reacting the resultant 2-(3-halomethyl-s-triazol-4-yl)benzophenone with hydroxylamine and subjecting the resultant 2-(3-hydroxyamino-methyl-s-triazol-4-yl)benzophenone to dehydration to effect ring closure.

  标题化合物是通过将3-氨基-3,4-二氢-4-羟基-4-苯基喹唑啉与卤代乙酸衍生物反应制备的，将所得的卤代乙酰衍生物与弱酸反应，将所得的2-(3-卤甲基-s-三唑-4-基)苯并酮与羟胺反应，并将所得的2-(3-羟氨基甲基-s-三唑-4-基)苯并酮脱水以实现环闭合。
• Benzodiazepine derivatives
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US04116956A1

  公开（公告）日：1978-09-26

  Benzodiazepine derivatives of the general formula ##STR1## where R.sub.1 is hydrogen or a hydrocarbon residue of 1-8 carbon atoms, R.sub.2 is hydrogen or lower alkyl and rings A and B are unsubstituted or substituted by nitro, trifluoromethyl, halogen, lower alkyl or lower alkoxy, the nitrogen atom in the 5-position being unsubstituted or substituted by an oxygen atom, useful as muscle relaxants, anticonvulsants, sedatives and tranquilizing agents, and processes for production thereof. Also provided are novel intermediates of the general formula ##STR2## where R.sub.2 has the above meaning, rings A and B are unsubstituted or substituted as above and the nitrogen atom in the 4-position is unsubstituted or substituted by an oxygen atom.

  苯二氮䓬类化合物的一般结构式为##STR1##其中R.sub.1为氢或1-8个碳原子的烃基残基，R.sub.2为氢或较低的烷基，环A和环B未取代或被硝基、三氟甲基、卤素、较低烷基或较低烷氧基取代，5-位的氮原子未取代或被氧原子取代，可用作肌肉松弛剂、抗惊厥剂、镇静剂和安定剂，并提供其生产方法。还提供了一般结构式为##STR2##的新中间体，其中R.sub.2具有上述含义，环A和环B未取代或如上所述取代，4-位的氮原子未取代或被氧原子取代。
• Indolobenzoquinoline derivatives, their preparation and their use as anti-arrhythmic drugs
  申请人：Sankyo Company Limited

  公开号：EP0415776A2

  公开（公告）日：1991-03-06

  Optically active compounds of formula (I): in which R1 is hydrogen or alkyl; Xb and Yb are hydrogen or hydroxy; and Z is -NRaRb in which Ra and Rb are hydrogen, alkyl or hydroxyalkyl, or a cyclic amino group; and pharmaceutically acceptable salts thereof have enhanced anti-arrhythmic activity and may be prepared by a stereospecific synthesis process.

  式(I)中的光学活性化合物：其中R1为氢或烷基；Xb和Yb为氢或羟基；Z为-NRaRb，其中Ra和Rb为氢、烷基或羟基烷基，或环状氨基；以及其药学上可接受的盐具有增强的抗心律失常活性，并可通过立体特异性合成过程制备。
• Method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins
  申请人：Regents of the University of Minnesota

  公开号：US05587491A1

  公开（公告）日：1996-12-24

  A method for the synthesis of bis-tetrahydrofuranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

  提供一种合成双四氢呋喃基番木酮类化合物的方法，包括天然产物及其类似物，该方法通过Pd介导的双四氢呋喃基亚乙炔基团与(C4)-羟基丁酮内酯亚基末端乙烯基碘的偶联反应进行，并随后选择性还原所得的炔烯化合物。
• 2-alkyl thieno(triazolo)diazepine compounds and pharmaceutical uses
  申请人：Yoshitomi Pharmaceutical Industries, Ltd.

  公开号：US04960770A1

  公开（公告）日：1990-10-02

  A thienotriazolodiazepine compound of the formula: ##STR1## wherein Ar is phenyl, pyridyl, substituted phenyl or substituted pyridyl; R.sup.1 and R.sup.3 are the same or different and each is hydrogen, alkyl having 1 to 4 carbon atoms; R.sup.2 is hydrogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl; R.sup.4 is straight or branched chain alkyl, alkenyl or alkynyl having 6 to 18 carbon atoms, or a thienodiazepine compound of the formula: ##STR2## wherein Ar, R.sup.1, R.sup.2 and R.sup.4 are as defined above, and pharmaceutically acceptable acid addition salt thereof. These compounds are useful as drugs for the treatment of circulatory diseases and various PAF-induced diseases. The compound (II) is also useful as an intermediate for preparing the compound (I).

  一种噻唑二氮杂环己烷类化合物的化学式如下：##STR1## 其中Ar为苯基、吡啶基、取代苯基或取代吡啶基；R.sup.1和R.sup.3相同或不同，每个都是氢、具有1至4个碳原子的烷基；R.sup.2为氢、具有1至4个碳原子的烷基或三氟甲基；R.sup.4为直链或支链烷基、烯基或炔基，具有6至18个碳原子，或者为噻唑二氮杂环己烷类化合物的化学式如下：##STR2## 其中Ar、R.sup.1、R.sup.2和R.sup.4如上所定义，并且其药学上可接受的酸盐。这些化合物可用作治疗循环系统疾病和各种PAF诱导疾病的药物。化合物（II）还可用作制备化合物（I）的中间体。